MXene-based mild potothermal therapy synergizes STING activation to enhance the efficacy of cancer vaccines post-cryoablation
Chemical Engineering Journal,
Год журнала:
2025,
Номер
505, С. 159311 - 159311
Опубликована: Янв. 6, 2025
Язык: Английский
Application and Recent Progress of MXene-Based Bioactive Materials in Wound Management
Nano TransMed,
Год журнала:
2025,
Номер
unknown, С. 100079 - 100079
Опубликована: Март 1, 2025
Язык: Английский
Recent advances in nanomaterials for integrated phototherapy and immunotherapy
Coordination Chemistry Reviews,
Год журнала:
2025,
Номер
535, С. 216608 - 216608
Опубликована: Март 27, 2025
Язык: Английский
MXene-based mild photothermal therapy synergizes STING activation to enhance the efficacy of cancer vaccines post-cryoablation
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 11, 2024
Abstract
Cryoablation
(CRA)
is
a
clinical
treatment
modality
for
minimally
invasive
local
tumor
ablation.
Rare
reports
have
shown
that
CRA
can
induce
cryoimmune
effect
and
enhance
systemic
anti-tumor
immunity
against
potential
metastases,
phenomenon
known
as
the
"abscopal
effect".
Here,
we
innovatively
propose
sequential
strategy
to
improve
immune
microenvironment
by
activating
cGAS-STING
signaling
pathway
mild
photothermal
therapy
(mPTT)
before
CRA,
making
this
rare
but
exciting
more
reproducible.
Specifically,
designed
functional
nanosheets
(Ti
3C
2@Au-PEG-DMXAA)
based
on
Ti
3C
2
MXene,
with
gold
nanoparticles
attached
surface,
PEGylated,
loaded
STING
agonist
(DMXAA).
Due
attachment
of
nanoparticles,
CT-guided
visual
injection
was
achieved.
The
synergistic
mPTT
activation
promoted
immunogenic
death
cells,
dendritic
repolarization
tumor-associated
macrophages,
enrichment
cytotoxic
T
cells
in
microenvironment.
Subsequently,
eradicated
"hot"
tumors,
initiating
"cancer
vaccine"
through
in-situ
gradual
release
antigens,
boosting
immunity,
generating
long-term
memory,
thereby
effectively
inhibiting
recurrence
metastasis.
Язык: Английский
Fabrication of Polydopamine‐Coated High‐Entropy MXene Nanosheets for Targeted Photothermal Anticancer Therapy
Qingshuang Zou,
Ailin Qiu,
Yan He
и другие.
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 24, 2024
Transition
metal
carbides,
nitrides,
and
carbonitrides
(MXenes)
have
emerged
as
a
promising
class
of
2D
materials
that
can
be
used
for
various
applications.
Recently,
new
form
high-entropy
MXenes
has
been
reported,
which
contains
an
increased
number
elemental
species
increase
the
configurational
entropy
reduce
Gibbs
free
energy.
The
unique
structure
composition
lead
to
range
intriguing
tunable
characteristics.
Herein,
fabrication
MXene
TiVNbMoC
Язык: Английский