A review of research progress on COF-based biosensors in pathogen detection
Analytica Chimica Acta,
Год журнала:
2025,
Номер
1342, С. 343605 - 343605
Опубликована: Янв. 7, 2025
Язык: Английский
Bioinspired Iron Porphyrin Covalent Organic Frameworks-Based Nanozymes Sensor Array: Machine Learning-Assisted Identification and Detection of Thiols
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(51), С. 71048 - 71059
Опубликована: Дек. 12, 2024
Given
the
crucial
role
of
thiols
in
maintaining
normal
physiological
functions,
it
is
essential
to
establish
a
high-throughput
and
sensitive
analytical
method
identify
quantify
various
accurately.
Inspired
by
iron
porphyrin
active
center
natural
horseradish
peroxidase
(HRP),
we
designed
synthesized
two
covalent
organic
frameworks
(Fe-COF-H
Fe-COF-OH)
with
notable
peroxidase-like
(POD)
activity,
capable
catalyzing
3,3′,5,5′-tetramethylbenzidine
(TMB)
into
oxidized
TMB
three
distinct
absorption
peaks.
Based
on
these,
six-channel
nanozyme
colorimetric
sensor
array
was
constructed,
which
could
map
specific
fingerprints
thiols.
Subsequently,
machine
learning
techniques,
including
supervised
linear
discriminant
analysis
(LDA),
decision
trees
(DT)
artificial
neural
networks
(ANN),
unsupervised
hierarchical
cluster
(HCA),
ensemble
random
forests
(RF),
were
used
for
precise
identification
complex
systems,
detection
limit
as
low
50
nM.
Significantly,
demonstrated
strong
potential
practical
applications,
analyzing
homocysteine
(Hcy)
human
serum,
mercaptoacetic
acid
(TGA)
depilatory
creams,
glutathione
(GSH)
cell
lysates,
thereby
showing
promise
use
disease
diagnosis.
Язык: Английский
Recent Advances in Nanozyme Sensors Based on Metal–Organic Frameworks and Covalent–Organic Frameworks
Xing-Liang Cheng,
Shuojiang Liu,
Yuling Hu
и другие.
Biosensors,
Год журнала:
2024,
Номер
14(11), С. 520 - 520
Опубликована: Окт. 23, 2024
Nanozymes
are
nanomaterials
that
exhibit
enzyme-like
catalytic
activity,
which
have
drawn
increasing
attention
on
account
of
their
unique
superiorities
including
very
high
robustness,
low
cost,
and
ease
modification.
Metal-organic
frameworks
(MOFs)
covalent-organic
(COFs)
emerged
as
promising
candidates
for
nanozymes
due
to
abundant
activity
centers,
inherent
porosity,
tunable
chemical
functionalities.
In
this
review,
we
first
compare
the
enzyme-mimicking
centers
mechanisms
between
MOF
COF
nanozymes,
then
summarize
recent
research
designing
modifying
with
activity.
Moreover,
typical
examples
sensing
applications
based
these
presented,
well
translation
enzyme
into
a
visible
signal
response.
At
last,
discussion
current
challenges
is
followed
by
some
future
prospects
provide
guidance
nanozyme
sensors
MOFs
COFs
practical
applications.
Язык: Английский
Recent Advance in the Synthesis and Applications of Chiral Covalent Organic Frameworks: A Mini‐Review
Journal of Separation Science,
Год журнала:
2025,
Номер
48(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Chiral
covalent
organic
frameworks
(CCOFs)
are
emerging
porous
materials
with
tunable
chiral
structures,
abundant
pores,
and
high
surface
areas,
gaining
significant
attentions
in
separation,
sensing,
asymmetric
catalysis.
This
review
summarizes
the
synthesis
methods
of
CCOFs
their
applications
recognition.
It
discusses
advantages
limitations
three
strategies,
including
post‐modification,
direct
synthesis,
chiral‐induced
synthesis.
The
also
highlights
potential
catalysis
for
efficient
purification,
detection,
molecules.
Challenges
future
directions
preparation
application
addressed,
aiming
to
guide
further
research
practical
applications.
Язык: Английский
One step synthesis of flexible covalent organic Frameworks in water for efficient separation of CO2/CH4
Xiaoxiang He,
Guo‐Wang Xu,
Jie Fan
и другие.
Separation and Purification Technology,
Год журнала:
2025,
Номер
unknown, С. 132582 - 132582
Опубликована: Март 1, 2025
Язык: Английский
Site‐Defined High‐Loading Tellurium Single‐Atom Nanozymes Anchored on Checkerboard‐Patterned Graphyne for Sensor Array Construction
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 22, 2025
Abstract
Single‐atom
nanozymes
exhibit
unique
enzymatic
activity
due
to
their
active
centers,
which
resemble
those
of
natural
metalloenzymes.
The
design
the
anchoring
sites
single‐atom
centers
is
an
important
factor
that
affects
loading
capacity
and
catalytic
activity.
Herein,
para‐nitrogen‐doped
graphyne
with
diamond
cavity
used
as
support,
tellurium
atoms
are
then
anchored
in
nitrogen‐containing
cavities,
akin
chess
pieces
placed
on
a
chessboard
grid.
Due
pre‐designed
regular
sites,
site‐defined
nanozyme
(Te
SAN)
achieves
high
Te
19.21
wt.%.
Therefore,
SAN
shows
good
peroxidase‐like
To
explain
enhanced
activity,
density
functional
theory
calculations
performed
results
demonstrate
doping
enhances
by
lower
Gibbs
free
energy
barrier
for
formation
•OH,
key
intermediate
Finally,
based
inhibitory
effect
bisphenols
SAN‐based
sensor
array
successfully
identifies
five
bisphenols,
holding
potential
on‐site
food
safety
monitoring.
single
this
work
provides
new
ideas
precisely
controlling
synthesis
nanozymes,
exploring
action
mechanisms,
enhancing
activities.
Язык: Английский
In Situ Valence Engineering of Copper Silicate Nanozymes with Enhanced Peroxidase‐Like Catalytic Activity for Oral Disease Detection
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 5, 2025
Abstract
As
a
series
of
attractive
nanomaterials,
nanozymes
with
great
catalytic
activity
and
specificity
are
well
developed
in
the
field
biosensors.
Although
promising,
lack
appropriate
structural
design
strategy
limitation
sensing
performance
clinical
samples
remain
challenging
for
practical
application
nanozymes.
Herein,
novel
copper
silicate
nanozyme
(CSHSs‐Ar)
enhanced
peroxidase‐like
is
synthesized
through
facile
situ
valence‐engineered
approach.
After
optimization
synthesis,
resultant
CSHSs‐Ar
containing
nearly
60%
Cu
+
hold
higher
better
than
other
two
derivatives
(CSHSs
CSHSs‐air).
Theoretical
calculations
also
demonstrate
that
more
beneficial
toward
activation
H
2
O
compared
CSHSs
CSHSs‐air.
On
this
basis,
well‐developed
nanozyme‐involved
system
employed
as
an
efficient
colorimetric
sensor
detection
volatile
sulfur
compounds
(VSCs)
prediction
periodontitis.
Moreover,
several
visual
molecular
logic
gates
explored
proof
concept
to
superior
activity.
This
study
not
only
provides
guidance
development
nanozymes,
but
broadens
biomedical
potential
including
oral
diseases.
Язык: Английский
Upgrading the Bioinspired Iron-Polyporphyrin Structures by Abiological Metals Toward New-Generation Reactive Oxygen Biocatalysts
Nano Letters,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 27, 2024
Developing
artificial
enzymes
based
on
organic
molecules
or
polymers
for
reactive
oxygen
biocatalysis
has
broad
applicability.
Here,
inspired
by
heme-based
enzyme
systems,
we
construct
the
abiological
iron
group
metal-based
polyporphyrin
(Ru/Os-coordinated
porphyrin-based
biocatalyst,
Ru/Os-PorBC)
to
serve
as
a
new
generation
of
efficient
and
versatile
species
(ROS)-related
biocatalyst.
Due
structural
benefits,
including
excellent
electron
configuration,
appropriate
bandgap,
optimized
adsorption
activation
reaction
intermediates,
Ru/Os-PorBC
shows
unparalleled
ROS-production
activities
regarding
maximum
rate
turnover
numbers,
which
also
demonstrates
superior
pH
temperature
adaptability
compared
natural
enzymes.
Impressively,
Os-PorBC
manifests
most
efficacious
capabilities,
surpassing
not
only
Ru/Fe-PorBC
but
existing
state-of-the-art
ROS-related
Our
findings
provide
pivotal
direction
developing
next-generation
polyporphyrin-based
biocatalysts,
setting
stage
era
upgrading
metalloenzymes
metals.
Язык: Английский