Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy

Chemical Reviews, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Язык: Английский

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The micro(nano)plastics perspective: exploring cancer development and therapy

Molecular Cancer, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 24, 2025

Microplastics, as an emerging environmental pollutant, have received widespread attention for their potential impact on ecosystems and human health. Microplastics are defined plastic particles less than 5 millimeters in diameter can be categorized primary secondary microplastics. Primary microplastics usually originate directly from industrial production, while formed by the degradation of larger items. capable triggering cytotoxicity chronic inflammation, may promote cancer through mechanisms such pro-inflammatory responses, oxidative stress endocrine disruption. In addition, improved bring new perspectives to therapy, studies drug carriers underway, showing high targeting bioavailability. Although current suggest association between certain cancers (e.g., lung, liver, breast cancers), long-term effects specific still need studied. This review aimed at exploring carcinogenicity promising applications therapy provides important directions future research emphasizes multidisciplinary collaboration address this global health challenge.

Язык: Английский

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Copper-doped layered double hydroxides co-deliver proteins/drugs for cascaded chemodynamic/immunotherapy via dual regulation of tumor metabolism

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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New horizons for the therapeutic application of nanozymes in cancer treatment

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 20, 2025

The advent of nanozymes has revolutionized approaches to cancer diagnosis and therapy, introducing innovative strategies that address the limitations conventional treatments. Nanozyme nanostructures with enzyme-mimicking catalytic abilities exhibit exceptional stability, biocompatibility, customizable functions, positioning them as promising tools for theranostics. By emulating natural enzyme reactions, can selectively target eradicate cells, minimizing harm adjacent healthy tissues. Nanozymes also be functionalized specific targeting ligands, allowing precise delivery regulated release therapeutic agents, improving treatment effectiveness reducing adverse effects. However, issues such selectivity, regulatory compliance remain critical challenges clinical application nanozymes. This review provides an overview nanozymes, highlighting their unique properties, various classifications, activities, diverse applications in strategic oncological deployment could profoundly impact future advancements personalized medicine, recent progress prospective directions enzyme-mimetic treatment. summarizes

Язык: Английский

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Multi‐Enzyme Nanoparticles as Efficient Pyroptosis and Immunogenic Cell Death Inducers for Cancer Immunotherapy

Advanced Science, Год журнала: 2024, Номер 11(44)

Опубликована: Окт. 9, 2024

Abstract Immunotherapy represents a widely employed modality in clinical oncology, leveraging the activation of human immune system to target and eradicate cancer cells tumor tissues via endogenous mechanisms. However, its efficacy remains constrained by inadequate responses within “cold” microenvironment (TME). In this study, multifunctional nanoscale pyroptosis inducer with cascade enzymatic activity (IMZF), comprising superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione oxidase (GSHO x ), is dissociated acidic glutathione‐rich TME. The vigorous not only generates oxygen (O 2 ) alleviate hypoxia promote M2 M1 macrophage polarization but also yields reactive species (ROS) depletes (GSH) Functioning as an immunogenic cell death (ICD) activator inducer, IMZF synergistically triggers dendritic maturation inflammatory lymphocyte infiltration ICD‐associated pyroptosis, thereby reversing suppression TMEs. Consequently, it exerts inhibitory effects on both primary distal tumors. This platform‐based offers intelligent strategy for effectively overcoming tumors, providing promising avenue advanced immunotherapeutic interventions.

Язык: Английский

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Study on the regulatory mechanisms of mitochondrial biosynthesis by polyoxometalates

Polyoxometalates, Год журнала: 2025, Номер 4(1), С. 9140074 - 9140074

Опубликована: Март 1, 2025

In recent years, polyoxometalates have been systematically studied in the treatment of diabetes, tumor, cancer, inflammation and other diseases vitro vivo, their main therapeutic mechanisms are related to generation reactive oxygen species causing oxidative stress. The site production is mitochondria, therefore, mechanism may be mitochondrial biosynthesis. This paper describes one diabetes mellitus, which involves increase species, resulting stress; at same time, preliminarily as antioxidants antitumor mellitus tumors, antioxidant properties provide an additional possibility for future a drug disease treatment; on basis study stress biomolecule due it, associating therapy actually closely through biosynthesis regulation relationship between mitochondria its impact three aspects order in-depth role drugs aspects.

Язык: Английский

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Zinc Cerium Peroxide Antibacterial Agent with Acid-Activated Cascade Multienzymatic Activities

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 2, 2025

Recently, metal peroxides with the ability to self-supply H2O2 have been intensively used in antibacterial and cancer therapy. However, performances are unsatisfactory due low efficiency of peroxide-mediated Fenton-like reaction. In this work, a novel zinc cerium bimetallic peroxide (CeZnOx) has first reported, which possesses acid-activated POD-like, OXD-like, CAT-like multienzymatic activities for efficiently bacterial inhibition. Specifically, CeZnOx self-supplying under weakly acidic conditions subsequently catalyzes production reactive oxygen species (ROS) through synergistically enhanced POD-like OXD-like activity. They can also exhibit activity catalyze excessive into O2 play an anti-inflammatory role normal pH conditions. The cascade inhibit growth alleviate hypoxia, improving microenvironment at wound site. As expected, exhibits superior effect on Staphylococcus aureus Escherichia coli. Therefore, CeZnOx-mediated offer simple promising strategy efficient treatment infections.

Язык: Английский

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H₂O₂‐Generating Advanced Nanomaterials for Cancer Treatment

Advanced Functional Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

Abstract Tumor cells exploit abnormal redox homeostasis and the pro‐tumorigenic effect of reactive oxygen species (ROS) to enhance their survival progression. However, excessively high levels ROS can exceed oxidative stress threshold tumor cells, inducing cell death. This occur by selectively elevating concentration H 2 O in through both endogenous exogenous mechanisms. The generated serves as a precursor for toxic ROS, such • OH 1 , via chemodynamic photodynamic therapy, respectively, leading apoptosis, necrosis, ferroptosis. Strategies boost include direct delivery amplifying generation inhibiting antioxidant enzymes, leveraging glucose oxidase, employing photocatalytic therapy (PCT), utilizing metal peroxides. Among them, peroxides have displayed remarkable performance due excellent potential elevate within while simultaneously normalizing acidic hypoxic conditions microenvironment (TME). Moreover, these nanostructures sensitivity complementary treatments, like chemotherapy. review summarizes advanced perspectives design, synthesis, comparative analysis ‐generating nanoplatforms, emphasizing capacity treat various cancers.

Язык: Английский

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Prostate Cancer-Targeting Liposome Loaded with Zinc Ion-Coordinated Photosensitizer for Enhanced Chemo-Photodynamic Therapy

Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 448 - 448

Опубликована: Март 31, 2025

Background: Prostate cancer (PCa) is the second most prevalent in males globally, impacting one out of every six males. However, therapeutic effect chemotherapy on PCa restricted. Methods: To address this, we developed a tumor-targeted multifunctional liposomal platform (PTX-PS/Zn@Lip-Apt) for zinc-enhanced chemo-photodynamic therapy PCa. Co-delivery PTX and an aggregation-induced emission photosensitizer (TPEDPD) enables combined photody-namic therapy. Zinc ions were loaded into liposomes to improve chemosensitivity chemodrugs. Then, AS1411 aptamer was further modified onto sur-face liposome enhance its tumor targeting ability. Moreover, cellular uptake efficiency nanoparticles, photochemical internalization (PCI) strategy also employed. Results: In vitro experiments indicated that conjugation PCI application enhanced cytotoxicity PTX/PS-Zn@Lip-Apt. The zinc ion could be found. vivo demonstrated good antitumor biosafety Conclusions: Our findings provide important basis innovatively applying prostate cancer.

Язык: Английский

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Cancer cell membrane-camouflaged pH-responsive nanoparticles for enhancing siRNA effect and synergistic anti-tumor therapy

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 7, 2025

RNA-based therapies, especially small interfering RNA (siRNA), have attracted extensive attention for tumor treatment. However, most siRNA can’t exert a therapeutic effect due to lack of targeting cells and entrapment in lysosomes upon administration. To address the challenges associated with delivery, delivery system was developed using zinc oxide nanoparticles (ZnO NPs) coated cancer cell membranes. ZnO been recognized as effective pH-responsive are widely used development drug systems pH-responsive. The NPs were combined chitosan encapsulate siRNA, allowing dissolution acidic subsequent release complexes. would also disrupt lysosomes, facilitating escape enhancing its gene silencing effect. nano-complexes (CS/ZnO@iRNA) unstable solution lacked specific cells. Thus, homologous membrane onto nanoparticles, which has shown be an strategy their stability capabilities. Moreover, not only dissolve enhance efficacy but elevate oxidative stress levels cells, leading induction cellular apoptosis. It demonstrated both in vitro vivo that could synergistically combine anti-tumor (siSurvivin) inhibit growth 4T1 tumor. Altogether, (CCM-CS/ZnO@siSurvivin) offers new while inhibiting growth.

Язык: Английский

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