Biomaterials, Год журнала: 2024, Номер 316, С. 123006 - 123006
Опубликована: Дек. 11, 2024
Язык: Английский
Aggregate, Год журнала: 2025, Номер unknown
Опубликована: Май 7, 2025
ABSTRACT Immunogenic cell death (ICD) has been demonstrated as a reliable approach to improve therapeutic effect in cancer treatment by triggering antitumor immunity. However, the trigger of ICD on basis chemotherapy and phototherapy meets obstacles serious side poor penetration ability, which seriously impedes effect. The development sonodynamic immunotherapy with evoking presents high promise for efficacy. Herein, performance aggregation‐induced emission (AIE) sonosensitizer is constructed engineering structure modulation sonodynamic‐augmented immunotherapy. By regulating intermolecular interaction pull‐push electronic effect, bearing AIE feature amplified sono‐sensitizing developed. In addition, vitro observation that thiolate‐substituted segment incorporation endows molecules enhanced cellular uptake efficiency improved tumor eradication ability. More importantly, developed could efficiently evoke upon ultrasound, allows efficient both at level solid tumor. inhibition primary further boost systemic immunity response complete elimination toward distant achieved. investigation highlights utilizing sonosensitizers conquer current limitation treatment.
Язык: Английский
Процитировано
0
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 11767 - 11788
Опубликована: Ноя. 1, 2024
The advent of acoustically responsive nanodrugs that are specifically optimized for sonodynamic therapy (SDT) is a novel approach clinical applications. Examining the therapeutic applications sono-responsive drug delivery systems, understanding their dynamic response to acoustic stimuli, and crucial role in enhancing targeted intriguing issues current cancer treatment. Specifically, suggested review covers SDT, modality enhances cytotoxic activity specific compounds (sonosensitizers) using ultrasound (US). Notably, SDT offers significant advantages treatment by utilizing US energy precisely target activate sonosensitizers toward deep-seated malignant sites. potential mechanisms underlying involve generation radicals from sonosensitizers, physical disruption cell membranes, enhanced transport into cells via US-assisted sonoporation. In particular, emerging as promising noninvasive, site-directed elimination solid tumors. Given complexity diversity tumors, many studies have explored integration with other treatments enhance overall efficacy. This trend has paved way SDT-based multimodal synergistic therapies, including sonophototherapy, sonoimmunotherapy, sonochemotherapy. Representative these approaches comprehensively presented, detailed discussion mechanisms. Additionally, application audible sound waves biological systems explored, highlighting influence cellular processes outcomes. Audible can modulate enzyme activities affect behavior, providing avenues use sound-based techniques medical highlights challenges prospects development nanomedicines this rapidly evolving research field. anticipated growth promises significantly improve precision
Язык: Английский
Процитировано
2
BME Frontiers, Год журнала: 2024, Номер 5
Опубликована: Янв. 1, 2024
Sonodynamic therapy (SDT) has emerged as a novel and highly researched advancement in the medical field. Traditional ultrasound contrast agents bubble-shaped are used to stimulate cavitation enhance SDT efficiency. However, impact of artificially modified shell structures on acoustic properties microbubbles remains be explored. Alternatively, absence agents, some clinically available organic sonosensitizers advanced inorganic materials also efficacy SDT. Diagnostic therapeutic can activate bubbles, which supply energy sonosensitive leading production cytotoxic free radicals achieve effects. While often spark controversy clinical applications, their relatively simple structure enables researchers gain insight into mechanism by produces various radicals. Some organic–inorganic hybrid systems have been reported, combining benefits agents. employing cell surface modification engineering enable cells perform functions such immune escape, drug loading, gas sonosensitivity, cellular developed. further exploration is needed properties, ability generate reactive oxygen species (ROS), potential application this sonosensitizer. This review offers comprehensive analysis vesical nanoscale sonocatalysts, including organic, inorganic, combined sonosensitizers, sonosensitizers. will our understanding demonstrate its important transforming applications.
Язык: Английский
Процитировано
1
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 21, 2024
Abstract Efficient management of difficult‐to‐heal diabetic wounds remains a clinical challenge owing to bacterial infections, as well oxidative and hyperglycemic complex pathology. Therefore, developing intelligent strategies for wound healing is urgently needed. Herein, an ultrasound (US)‐responsive microneedle (MN) patch ( MN@GOX@TiO 2‐X @CO ) capable controlled delivery carbon monoxide (CO) gas within the skin effective treatment infected developed. Benefiting from specific form patch, sonosensitizer (TiO ), •OH‐responsive CO prodrug (MPA‐CO), glucose oxidase (GOX) can be loaded together effectively delivered infectious wounds. With semi‐fluidic hyaluronic acid (HA) coating under physiological condition, could released efficiently in situ directly acted on tissue upon US triggering. Both vitro vivo results showed that US‐triggered release not only inhibited S. aureus MRSA infection but also promoted fibroblasts proliferation migration physiology, thereby accelerating healing. Collectively, approach addresses impaired regeneration function offers promising therapeutic strategy efficient
Язык: Английский
Процитировано
1
Biomaterials, Год журнала: 2024, Номер 316, С. 123006 - 123006
Опубликована: Дек. 11, 2024
Язык: Английский
Процитировано
0