Sprayable Hydrogel for pH-Responsive Nanozyme-Derived Bacteria-Infected Wound Healing
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 20, 2025
Long-term
inflammation
and
persistent
bacterial
infection
are
primary
contributors
to
unhealed
chronic
wounds.
The
use
of
conventional
antibiotics
often
leads
bacteria
drug
resistance,
diminishing
wound
healing
effectiveness.
Nanozymes
have
become
a
promising
alternative
antimicrobial
materials
due
their
low
cost,
easy
synthesis,
good
stability.
Herein,
we
develop
novel
sprayable
hydrogel
based
on
carboxymethyl
chitosan
(CMCS)
oxidized
hyaluronic
acid
(OHA),
incorporating
Au
nanoparticle-carbon
nitride
(AuNPs-C3N4)
nanozyme,
glucose,
Mn2+
for
bacteria-infected
healing.
forms
rapidly
in
situ
upon
spraying
gradually
degrades
the
area,
releasing
AuNPs-C3N4
which
exhibits
robust
glucose
oxidase-like
(GOx-like)
activity,
initiating
comprehensive
catalytic
cascade
through
Mn2+-mediated
Fenton-like
reaction
that
generates
hydroxyl
radicals
(•OH)
eliminate
Staphylococcus
aureus
(S.
aureus)
Methicillin-resistant
S.
(MRSA).
Computational
results
indicate
interactions
between
AuNPs
g-C3N4
maximize
synergistic
effects
heterojunction,
improving
O2
adsorption
facilitating
electron-O2
optimize
activity.
Further
experiments
demonstrate
can
cover
wounds
situ,
while
CMCS
promotes
collagen
production
fibroblast
proliferation,
offering
viable
strategy
Язык: Английский
Bacterial Programmed Cell Death Induced by Nanotherapeutic Strategies
ACS Materials Letters,
Год журнала:
2024,
Номер
6(9), С. 4209 - 4229
Опубликована: Авг. 19, 2024
Programmed
cell
death
(PCD)
is
crucial
for
renewal,
embryogenesis,
the
immune
response,
tissue
growth
regulation,
and
other
essential
biological
processes.
Recent
evidence
underscores
potential
of
harnessing
PCD
to
combat
bacterial
infections,
particularly
in
eradicating
antibiotic-resistant
superbugs.
Extensive
efforts
have
been
devoted
developing
PCD-mediated
anti-infective
agents
by
drawing
insights
from
materials
science,
chemistry,
immunology,
microbiology.
In
this
review,
challenges
addressing
infections
PCD-based
approaches
revolutionize
treatment
are
first
summarized
discussed.
Then,
a
comprehensive
examination
nanoantibacterial
therapy,
encompassing
various
pathways,
such
as
apoptosis,
ferroptosis,
cuproptosis,
immunogenic
death,
NETosis,
autophagy,
pyroptosis,
provided.
Finally,
barriers
prospects
PCD-driven
antimicrobial
strategies
explored.
Язык: Английский
Gold nanocage-carbon nanodot composites activate ornidazole against biofilm infections through modulating the hypoxic microenvironment
Surfaces and Interfaces,
Год журнала:
2025,
Номер
unknown, С. 106222 - 106222
Опубликована: Март 1, 2025
Язык: Английский
AuCu@CuO2 Aerogels with H2O2/O2 Self‐Supplying and Quadruple Enzyme‐Like Activity for MRSA‐Infected Diabetic Wound Management
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 27, 2025
Abstract
Diabetic
wound
healing
presents
serious
clinical
challenges
due
to
the
unique
microenvironment
characterized
by
hyperglycemia,
bacterial
infection,
excessive
oxidative
stress,
and
hypoxia.
Herein,
a
copper
peroxide
(CuO
2
)‐coated
AuCu
bimetallic
aerogel
is
developed
that
exhibits
quadruple
enzyme‐mimicking
activity
H
O
/O
self‐supplying
modulate
complex
of
methicillin‐resistant
staphylococcus
aureus
(MRSA)
‐infected
diabetic
wounds.
The
AuCu@CuO
aerogels
demonstrate
favorable
photothermal
properties
mimic
four
enzyme‐like
activities:
peroxidase‐like
for
producing
toxic
reactive
oxygen
species;
catalase‐like
decomposing
release
relieve
stress
hypoxia;
glucose
oxidase‐like
reducing
blood
glutathione
balancing
abnormal
level.
CuO
coating
facilitates
continuous
adequate
in
situ
production
within
mildly
acidic
infection
microenvironment,
enabling
excellent
antibacterial
reduced
levels
during
initial
treatment
infected
Furthermore,
engineered
not
only
scavenge
elevated
ROS
inflammatory
phase
but
also
synergistically
generate
promote
healing.
Overall,
aerogelsmicroenvironment
can
be
activated
microenvironments,
alleviating
inflammation,
hypoxia,
lowering
levels,
enhancing
angiogenesis
collagen
fiber
accumulation,
thereby
significantly
improving
Язык: Английский
Photocatalysis and Photodynamic Therapy in Diabetic Foot Ulcers (DFUs) Care: A Novel Approach to Infection Control and Tissue Regeneration
Molecules,
Год журнала:
2025,
Номер
30(11), С. 2323 - 2323
Опубликована: Май 26, 2025
Photocatalysis
and
photodynamic
therapy
have
been
increasingly
used
in
the
management
of
diabetic
foot
ulcers
(DFUs),
their
integration
into
innovative
treatment
protocols
enables
effective
infection
control.
Advanced
techniques
such
as
antibacterial
(aPDT),
liposomal
photocatalytic
carriers,
nanoparticles,
nanomotors—used
alone,
combination,
or
with
addition
antibiotics,
lysozyme,
phage
enzymes—offer
promising
solutions
for
wound
treatment.
These
approaches
are
particularly
even
presence
comorbidities
angiopathies,
neuropathies,
immune
system
disorders,
which
common
among
patients.
Notably,
use
combination
therapies
holds
great
potential
addressing
challenges
within
ulcers,
including
hypoxia,
poor
circulation,
high
glucose
levels,
increased
oxidative
stress,
rapid
biofilm
formation—factors
that
significantly
hinder
healing
The
modern
therapeutic
strategies
is
essential
clinical
practice,
starting
halting
progression,
ensuring
its
eradication,
promoting
proper
tissue
regeneration,
especially
considering
that,
according
to
WHO,
830
million
people
worldwide
suffer
from
diabetes.
Язык: Английский
Glucose‐Responsive and Analgesic Gel for Diabetic Subcutaneous Abscess Treatment by Simultaneously Boosting Photodynamic Therapy and Relieving Hypoxia
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 28, 2025
Abstract
The
treatment
of
diabetic
abscess
remains
highly
challenging
due
to
the
complex
wound
healing
environment,
which
includes
bacterial
infection,
hypoxia,
and
pain,
severely
compromising
patients'
quality
life.
Developing
effective
strategies
address
these
multifaceted
issues
continues
pose
significant
challenges.
In
this
study,
a
glucose‐triggered
gel
with
self‐producing
oxygen,
photodynamic
behavior,
analgesic
properties
is
employed
aforementioned
problems.
utilizes
cascade
reaction
glucose
oxidase
catalase
convert
excessive
in
tissue
into
alleviate
hypoxia
infected
tissue,
ensure
occurrence
behavior
generate
sufficient
reactive
oxygen
species
(ROS)
combat
pathogenic
bacteria.
Simultaneously,
borneol
within
can
not
only
enhance
sensitivity
bacteria
ROS
by
regulating
oxidative
stress
system
but
also
augment
antibacterial
effect
ROS.
Moreover,
serve
as
an
pain
patients.
vivo
experiments
have
demonstrated
that
combination
therapy
eliminate
at
site
enable
heal
completely
12
days.
Therefore,
study
established
glucose‐responsive
for
combined
strategy
hypoxic
improvement
facilitate
abscesses.
Язык: Английский
Metal-organic frameworks treating diabetic skin wounds by endogenous/exogenous responses
Next Nanotechnology,
Год журнала:
2025,
Номер
7, С. 100177 - 100177
Опубликована: Янв. 1, 2025
Язык: Английский
The Three‐Pronged Strategy: A Bilayer Hydrogel Treats Diabetic Chronic Wound through Microalgae Oxygen Therapy, Ag─FA NP Antibacterial, and Synergistic Scavenging of ROS
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 4, 2025
Abstract
Due
to
hypoxia,
excessive
reactive
oxygen
species
(ROS),
dense
bacterial
biofilms,
and
complex
inflammatory
microenvironment,
chronic
diabetic
wound
healing
presents
a
huge
challenge.
Currently,
sustainable
treatments
for
this
multifaceted
problem
have
not
been
found.
Here,
microalgae
silver
(Ag)─fulvic
acid
(FA)
NPs
are
used
develop
multinetwork
hydrogel
(C@Ag─KGCM)
based
on
oxidized
konjac
glucomannan
(OKG)
the
treatment
of
(DCW).
The
lower
carries
microrobots
Chlamydomonas
rheinhardtii
(C.
rheinhardtii)
,
which
continuously
release
bio‐oxygen
under
light
irradiation
alleviate
hypoxia
in
deep
tissues.
upper
layer
Ag─FA
formed
by
Ag
+
FA
self‐assembly
chelation
complex,
can
effectively
inhibit
growth
remove
biofilms
through
photothermal‐therapy‐based
Near
‐
Infrared
(NIR)
808
nm.
C.
reinhardtii
synergistically
scavenge
ROS.
Therefore,
new
concept
“three‐pronged
strategies”
that
addresses
multiple
problems
microenvironment
patients
has
proposed.
Histological
analysis
tissues
shows
C@Ag─KGCM
bilayer
promote
tissue
regeneration,
indicating
promising
potential
its
DCW
healing.
Язык: Английский