Radiotherapy plus a self-gelation powder encapsulating tRF5-GlyGCC inhibitor potentiates natural kill cell immunity to prevent hepatocellular carcinoma recurrence

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Фев. 10, 2025

Abstract Hepatocellular carcinoma (HCC) recurrence postresection represents a thorny problem in clinical practice, of which impaired natural killer (NK) cell cytotoxicity one crucial causes. Apart from recurrence, hepatectomy-induced abdominal adhesion also poses huge challenges such as pain, intestinal obstruction, and perforation. Evidence demonstrates that radiotherapy can upregulate NK group 2D ligand expression on tumor cells to enhance cytotoxicity, indicating its great potential curbing HCC recurrence. Nevertheless, has been disclosed incur suppression antitumor immunity. Herein, we reveal glycocholic acid (GCA)/tRNA-derived fragment 5 (tRF5)-GlyGCC signaling axis is activated mouse model after radiotherapy, dampens immunity limit therapeutic efficacy. Mechanistically, tRF5-GlyGCC interact with KDM6B epigenetically Runx2 then transcriptionally activate ITGBL1 S100A9 cells, further reduces directly attracts myeloid-derived suppressor (MDSC) inhibit function indirectly, respectively. Therefore, plus targeting may be an optimized postoperative adjuvant therapy against Then, nanocomposite powder designed for liver-localized delivery inhibitor. After sprayed liver resection margin model, this rapidly form in-situ Janus-adhesive hydrogel, allows sustained Importantly, it synergize potentiate prevent postresection. Moreover, application surgical bed effectively mitigates rat hepatectomy model. Altogether, our work develops tRF5-GlyGCC-targeting power sensitizing thwart preventing adhesion. Graphical

Язык: Английский

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Janus hydrogel microrobots with bioactive ions for the regeneration of tendon-bone interface

Nature Communications, Год журнала: 2025, Номер 16(1)

Опубликована: Март 4, 2025

Regenerating natural gradients of the tendon‒bone interface (TBI) is a major challenge in reconstruction rotator cuff tear (RCT). In this study, magnetic Janus hydrogel microrobots to match TBI orientation during RCT surgery are developed via biofriendly gas-shearing microfluidic platform. Through separate loading Mg2+ and Zn2+, facilitate immediate restoration long-term maintenance mineral gradient after implantation alignment through manipulation. vitro studies confirm spatiotemporal cell phenotype modulation effects microrobots. rat model, synchronously promote bone tendon regeneration, transition structures TBI. Overall, by rebuilding Mg2+/Zn2+ gradient, structural TBI, loaded with dual bioactive ions represent promising strategy for promoting healing surgery.

Язык: Английский

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Anisotropic Microcarriers: Fabrication Strategies and Biomedical Applications

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 21, 2025

Anisotropic microcarriers (AMs) have attracted increasing attention. Although significant efforts been made to explore AMs with various morphologies, their full potential is yet be realized, as most studies primarily focused on materials or fabrication methods. A thorough analysis of the interactional and interdependent relationships between these factors required, along proposed countermeasures tailored for researchers from backgrounds. These include specific strategies morphologies guidelines selecting suitable AM certain biomedical applications. In this review, a comprehensive summary AMs, ranging methods applications, based past two decades research, provided. The investigated using different corresponding By systematically examining morphology-dependent effects, better utilization diverse can achieved clear breakthroughs in field are established. Additionally, challenges identified, new frontiers opened, promising exciting opportunities provided fabricating functional broad implications across fields that must addressed biomaterials biotechnology.

Язык: Английский

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Injectable polyphenol hydrogel prevents peritoneal adhesion intensified by intraperitoneal microbial infection

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163134 - 163134

Опубликована: Апрель 1, 2025

Язык: Английский

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Zwitterion nanocomposite hydrogels with bioactivity and anti-adhesion properties for Rapid Prevention of Postoperative and Recurrent Adhesion

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101811 - 101811

Опубликована: Апрель 1, 2025

Язык: Английский

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Nanosilicate Embedded Zwitterionic Hydrogel with Improved Bioactivity for Rapid Prevention of Postoperative and Recurrent Adhesion

Опубликована: Янв. 1, 2024

Язык: Английский

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