Recent advances in self-targeting natural product-based nanomedicines

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 20, 2025

Язык: Английский

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Promising Nanoparticles-Based Oral Therapy for Effective Inhibition of Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Nano Letters, Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Portal vein tumor thrombus (PVTT) is a poor prognostic factor for hepatocellular carcinoma (HCC) patients, highlighting the need an oral drug delivery system that combines convenience, simplicity, biosafety, and improved patient compliance. Leveraging unique anatomy of portal insights from single-cell RNA sequencing PVTT microenvironment, we developed pellets using CaCO3@PDA nanoparticles (NPs) encapsulating both doxorubicin hydrochloride low molecular weight heparin. These NPs target aiming to break down barrier turn challenge blockage into advantage by enhancing efficiency through administration. The NPs-based achieved excellent antitumor effects with minimal side effects, demonstrating promising strategy managing in advanced HCC addressing types associated vascular invasion hypercoagulability.

Язык: Английский

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Calcium peroxide functionalized mesoporous polydopamine nanoparticles triggered calcium overload for synergistic tumor gas/photothermal therapy

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 690, С. 137332 - 137332

Опубликована: Март 14, 2025

Язык: Английский

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Multifunctional glycyrrhizic acid-loaded nanoplatform combining ferroptosis induction and HMGB1 blockade for enhanced tumor immunotherapy

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 19, 2025

Inducing ferroptotic cell death has been recognized as a promising approach in cancer therapy. However, ferroptosis can provoke tumor infiltration by myeloid-derived suppressor cells (MDSCs) through HMGB1 secretion, causing suppressive immune response. On the other hand, also occurs due to its non-selective properties, which compromise anti-tumor immunity. To address these challenges, two-pronged is proposed, encompassing selectively triggered and blockade, aimed at eliciting systemic immunity alleviating immunosuppression. Herein, GSH-specific driven nanoplatform composed of uniform FeOOH nanospindles coated with tetrasulfide bond-bridged mesoporous organosilica (DMOS) shell, loaded inhibitor, glycyrrhizic acid (GA). This endowed high glutathione (GSH) depletion efficiency exhibits highly efficient Fe2+ ROS generation capacity, promotes accumulation LPO subsequently induces ferroptosis. Concurrently, inhibition release counteracts immunosuppressive effects within microenvironment. innovative effectively suppresses growth 4T1 tumors notably enhancing therapeutic outcomes checkpoint blockade across experimental data. The collective findings indicate potential reliable strategy for boosting ferroptosis-mediated favorable safety profiles.

Язык: Английский

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A robust Metal–Organic Framework-Based nanozyme with Multienzyme-Like properties for synergistic tumor therapy via efficient and sustainable Nitric oxide generation

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 693, С. 137603 - 137603

Опубликована: Апрель 15, 2025

Язык: Английский

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A cascaded amplification carrier-free nanoplatform for synergistic photothermal/ferroptosis therapy via dual antioxidant pathway disruption in cervical cancer

Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Dual-laser triggered carrier-free self-assembly nano-photosensitizers (Ir-TCF 3 P-FA NPs) with trimodal imaging performance significantly inhibited the progression of human cervical cancer through synergistic photothermal/ferroptosis therapy.

Язык: Английский

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A cerium-based ferroptosis/PANoptosis nano-inducer for photothermal-enhanced combination therapy of breast cancer

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 163961 - 163961

Опубликована: Май 1, 2025

Язык: Английский

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Injectable Nanosuspension based on Orthoester for Synergistic Chemo-Photothermal/Gas Therapy in Localized Cancer Treatment

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 254, С. 114841 - 114841

Опубликована: Июнь 1, 2025

Язык: Английский

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Hyaluronic acid application strategies for plant bioactive component delivery: A review

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 282, С. 137129 - 137129

Опубликована: Окт. 31, 2024

Язык: Английский

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Photothermal nanocomposite reactivate “immune-hot” for triple-negative breast cancer treatment via glutamine metabolism reprograming

Colloids and Surfaces B Biointerfaces, Год журнала: 2024, Номер 245, С. 114268 - 114268

Опубликована: Сен. 24, 2024

Язык: Английский

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