Potential role of SIRT1 in cell ferroptosis

Frontiers in Cell and Developmental Biology, Год журнала: 2025, Номер 13

Опубликована: Март 5, 2025

Ferroptosis is a novel form of cell death that uniquely requires iron and characterized by accumulation, the generation free radicals leading to oxidative stress, formation lipid peroxides, which distinguish it from other forms death. The regulation ferroptosis extremely complex closely associated with spectrum diseases. Sirtuin 1 (SIRT1), NAD + -dependent histone deacetylase, has emerged as pivotal epigenetic regulator potential regulate through wide array genes intricately metabolism, homeostasis, glutathione biosynthesis, redox homeostasis. This review provides comprehensive overview specific mechanisms SIRT1 regulates explores its therapeutic value in context multiple disease pathologies, highlighting significance SIRT1-mediated treatment strategies.

Язык: Английский

Nanogenerator with L-Arginine loading: new choices as cascaded and synergistic nitric oxide/photodynamic antitumor agents

Materials Chemistry Frontiers, Год журнала: 2024, Номер 9(2), С. 204 - 222

Опубликована: Ноя. 27, 2024

In this review, the design idea, synergistic mechanism and application prospects of l -arginine-loaded nanogenerators with cascade NO/PDT for anti-tumor applications are summarized.

Язык: Английский