Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats

Immunity Inflammation and Disease, Год журнала: 2025, Номер 13(1)

Опубликована: Янв. 1, 2025

ABSTRACT Background Traumatic spinal cord injury (SCI) is an incurable condition that the largest cause of disability. In previous studies, Isosteviol sodium (STVNa) has been shown to protect rats against acute focal cerebral ischemia; however, effects STVNa on SCI recovery in remain unknown. Methods was given intraperitoneally after see if it had any neuroprotective benefits. On Days 7, 14, 21, and 28 post‐SCI, functional measured using Basso, Beattie, Bresnahan (BBB) scoring system along with oblique plate test. Following these evaluations, tissues were harvested for analysis. All behavioral testing occurred between 8 a.m. 3 p.m. Results We found improved rats, as evidenced by enhanced BBB locomotor rating scale, angle inclination, decreased cavity damage, neuron death vivo. addition, reduced inflammation following SCI, demonstrated a reduction proinflammatory cytokines such tumor necrosis factor (TNF)‐α, interleukin (IL)‐6, (IL)‐1β. also oxidative damage lowering ROS while raising SOD levels. Conclusion These findings suggest protects through variety pathways. STVNa, particular, may benefit reducing stress inflammation, leading activity SCI.

Язык: Английский

Engineered hybrid exosomes responsive to reactive oxygen species target the treatment of spinal cord injury by repairing mitochondrial damage and promoting neuronal function recovery

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 160669 - 160669

Опубликована: Фев. 1, 2025

Язык: Английский

Novel carbon dots with dual Modulatory effects on the bone marrow and spleen as a potential therapeutic candidate for treating spinal cord injury

Bioactive Materials, Год журнала: 2024, Номер 45, С. 534 - 550

Опубликована: Дек. 11, 2024

Язык: Английский