Rapid neuralized and vascularized osteogenesis in infected bone defect using biomimetic biomineralized and antibacterial hydrogels DOI Creative Commons
Yuhao Deng, Song Chen, Tuerxun Maimaitiaili

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Май 21, 2025

Infected bone defects represent one of the most prevalent clinical conditions, affecting millions patients annually. The local infection and necrosis associated with these exacerbate injury, prolong healing times, result in significant localized pain, presenting a substantial challenge for repair. In this study, we developed biomimetic mineralized antibacterial imCOL1MA hydrogel by employing methacrylated COL1, composite native inorganic salts (CNBIS), Magainin II-PLGA microspheres (mMicrospheres), which was further loaded marrow stem cells (BMSCs) to form osteogenic engineered infected Briefly, first optimized concentration COL1MA BMSCs survival, then adjusted proportion CNBIS create an appropriate osteoinductive microenvironment, encapsulated II poly (lactic-co-glycolic acid) (PLGA) microsphere long-term antimicrobial function. Consequently, promising prepared using 10% COL1MA, 2% CNBIS, 1% mMicrospheres. scaffold served as efficacy, excellent biodegradability, good biocompatibility, microenvironment. As result, could achieve rapid (only 4 weeks) vascularized neuralized regeneration rabbit model defects.

Язык: Английский

Bioactive hydrogel formulations for regeneration of pathological bone defects DOI
Zuhao Li, Kaixuan Ren, Jiajia Chen

и другие.

Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 686 - 714

Опубликована: Фев. 17, 2025

Язык: Английский

Процитировано

3
Carbon Quantum Dots in Biomedical Applications: Advances, Challenges, and Future Prospects DOI Creative Commons
Н. А. Печникова, Kalliopi Domvri, Κonstantinos Porpodis

и другие.

Aggregate, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 28, 2024

ABSTRACT Carbon quantum dots (CQDs) represent a rapidly emerging class of nanomaterials with significant potential in biomedical applications due to their tunable fluorescence, high biocompatibility, and versatile functionalization. This review focuses on the recent progress utilizing CQDs for drug delivery, bioimaging, biosensing, cancer therapy. With unique optical properties, such as yield, photostability, enable precise bioimaging sensitive biosensing. Their small size, ease surface functionalization allow development targeted delivery systems, enhancing therapeutic precision minimizing side effects. In therapy, have shown photodynamic photothermal treatments by generating reactive oxygen species under light exposure, selectively targeting cells while sparing healthy tissues. Furthermore, CQDs’ ability penetrate biological barriers including blood–brain barrier opens new possibilities delivering agents hard‐to‐reach areas, tumors or diseased However, challenges optimizing synthesis, ensuring long‐term stability, addressing safety concerns environments remain critical hurdles. discusses current efforts overcome these improve CQD performance clinical settings, scalable production methods enhanced biocompatibility. As research progresses, are expected play an important role improving healthcare offering more treatment options contributing advancements personalized medicine.

Язык: Английский

Процитировано

3
CircAars‐Engineered ADSCs Facilitate Maxillofacial Bone Defects Repair Via Synergistic Capability of Osteogenic Differentiation, Macrophage Polarization and Angiogenesis DOI Creative Commons

Yi He,

Yunyang Lu,

Runze Li

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Abstract Adipose‐derived stem cells (ADSCs) hold significant promise in bone tissue engineering due to their self‐renewal capacity and easy accessibility. However, limited osteogenic potential remains a critical challenge for clinical application repair. Emerging evidence suggests that circular RNAs (circRNAs) play key role regulating cell fate osteogenesis. Despite this, the specific mechanisms by which circRNAs influence ADSCs context of are largely unexplored. This study introduces novel strategy utilizing circAars, circRNA, modify ADSCs, then incorporated into gelatin methacryloyl (GelMA) hydrogels repair critical‐sized maxillofacial defects. The findings reveal circAars predominantly localizes cytoplasm where it acts as competitive sponge miR‐128‐3p, enhancing differentiation migration capabilities ADSCs. Furthermore, circAars‐engineered facilitate macrophage polarization from M1 M2 phenotype enhance endothelial (EC) angiogenic through paracrine mechanism. Additionally, GelMA scaffolds loaded with accelerate defects synergistically promoting osteogenesis, polarization, angiogenesis. approach offers promising therapeutic treatment

Язык: Английский

Процитировано

0
Bifunctional cobalt ferrite/reduced graphene oxide heterojunction enhances the antibacterial and osteogenic activities of scaffold DOI
Cijun Shuai, Chong Lin, Xiuwen Gao

и другие.

Applied Surface Science, Год журнала: 2025, Номер unknown, С. 162942 - 162942

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Inflammatory Microenvironment-Modulated Conductive Hydrogel Promotes Vascularized Bone Regeneration in Infected Bone Defects DOI
Qian Yang, Tianli Wu, Xianghao Wu

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2025, Номер unknown

Опубликована: Март 12, 2025

Infected bone defects show a significant reduction in neovascularization during the healing process, primarily due to persistent bacterial infection and immune microenvironmental disorders. Existing treatments are difficult simultaneously meet requirements of antibacterial anti-inflammatory for infected defects, which is key clinical therapeutic challenge that needs be addressed. In this study, conductive hydrogel based on copper nanoparticles was developed controlling remodeling microenvironment. The not only effectively eliminates bacteria exist defect region but also transmits electrical signals restore disordered vitro studies have shown has excellent biocompatibility can modulate macrophage polarization by transmitting reduce inflammation promote neovascularization. vivo further confirmed scaffold rapidly cleared infections significantly induced formation vascularized new tissue within 4 weeks. This work provides simple innovative strategy fabricate copper-containing hydrogels great potential application field therapeutics regeneration.

Язык: Английский

Процитировано

0
Piezoelectric Iridium-Doped Bismuth Ferrite/Sodium Alginate Hydrogel for Antibiosis and Stimulating Osteoblastic Differentiation DOI

Lei Sun,

Weijie Yang,

Shangyu Xie

и другие.

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Язык: Английский

Процитировано

0
MXene and Near‐Infrared Carbon Dots Co‐Encapsulated Hydrogel Facilitates Infected Bone Defect Reconstruction DOI

Longfei Xiao,

Yang Wang, Jinming Cai

и другие.

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

Inadequate bone differentiation and intractable biofilm formation due to stubborn bacterial infection complicate infected defect repair. Adding harmful antibiotics into scaffolds not only promotes multidrug-resistant bacteria but also decreases repair effect. Furthermore, dynamic monitor of scaffolds' degradation is crucial for achieving visualized repair, however, currently reported biomaterials do have imaging tracing capabilities. On this basis, work develops a scaffold material with triple functionality therapy defects: antibacterial, osteogenesis, near-infrared (NIR) Single-layer Ti3C2Tx broad-spectrumantibacterial activity negatively charged carbon dots (CDs) osteogenic are synthesized To validate antibacterial activities in vivo, 3D injectable hydrogels encapsulated CDs (CD/Ti3C2Tx/GelMA) constructed. NIR used the process CD/Ti3C2Tx/GelMA models, which indicated that completely released from about 30 days. Owing continuous release CDs, obtained can efficiently promote defects within 60 These findings develop new biomaterial great performance defects.

Язык: Английский

Процитировано

0
3D printed Gel/PTH@PAHA scaffolds with both enhanced osteogenesis and mechanical properties for repair of large bone defects DOI Creative Commons

Zhimou Zeng,

Ping Song,

Xingyu Gui

и другие.

Regenerative Biomaterials, Год журнала: 2025, Номер 12

Опубликована: Янв. 1, 2025

Abstract The repair of large bone defects continues to pose a significant challenge in clinical orthopedics. Successful repairs require not only adequate mechanical strength but also exceptional osteogenic activity for successful translation. Composite materials based on polyamide 66 (PA66) and hydroxyapatite have been widely used various settings. However, existing PA66/hydroxyapatite composites often lack sufficient stimulation despite their favorable properties, which limit overall efficacy. In this study, we fabricated 66/nano-hydroxyapatite (PAHA) scaffold using an extruder fused deposition modeling-based 3D printing technology. Subsequently, gelatin methacrylamide (GelMA) containing teriparatide (PTH) was incorporated into the PAHA construct Gel/PTH@PAHA scaffold. Material characterization results indicated that compressive modulus elasticity were 172.47 ± 5.48 MPa 25.55 2.19 MPa, respectively. vitro evaluations demonstrated significantly enhanced osteoblast adhesion proliferation while promoting differentiation BMSCs. vivo studies further revealed notably promoted new regeneration rabbit femoral defects. These findings suggest 3D-printed exhibits excellent properties alongside remarkable activity, thereby meeting dual requirements load-bearing applications regeneration. This innovative approach may be promising candidate customized orthopedic implants with substantial potential application.

Язык: Английский

Процитировано

0
Fire ant-inspired bone repair breakthrough: Self-assembly strategy of microspheres driven by physical hydrogen bonding and hydrophobic interactions DOI
Rui Zhang, Yijing Stehle, Qiang Chen

и другие.

Chemical Engineering Journal, Год журнала: 2025, Номер 515, С. 163723 - 163723

Опубликована: Май 13, 2025

Язык: Английский

Процитировано

0
Rapid neuralized and vascularized osteogenesis in infected bone defect using biomimetic biomineralized and antibacterial hydrogels DOI Creative Commons
Yuhao Deng, Song Chen, Tuerxun Maimaitiaili

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 13

Опубликована: Май 21, 2025

Infected bone defects represent one of the most prevalent clinical conditions, affecting millions patients annually. The local infection and necrosis associated with these exacerbate injury, prolong healing times, result in significant localized pain, presenting a substantial challenge for repair. In this study, we developed biomimetic mineralized antibacterial imCOL1MA hydrogel by employing methacrylated COL1, composite native inorganic salts (CNBIS), Magainin II-PLGA microspheres (mMicrospheres), which was further loaded marrow stem cells (BMSCs) to form osteogenic engineered infected Briefly, first optimized concentration COL1MA BMSCs survival, then adjusted proportion CNBIS create an appropriate osteoinductive microenvironment, encapsulated II poly (lactic-co-glycolic acid) (PLGA) microsphere long-term antimicrobial function. Consequently, promising prepared using 10% COL1MA, 2% CNBIS, 1% mMicrospheres. scaffold served as efficacy, excellent biodegradability, good biocompatibility, microenvironment. As result, could achieve rapid (only 4 weeks) vascularized neuralized regeneration rabbit model defects.

Язык: Английский

Процитировано

0