Gossypin-Loaded Ethosome Gel for Cutaneous Administration: A Preliminary Study on Melanoma Cells

Antioxidants, Год журнала: 2025, Номер 14(2), С. 186 - 186

Опубликована: Фев. 5, 2025

A preformulative study was conducted to produce and characterize ethosomes for the transdermal delivery of gossypin. This plant-derived compound possesses many pharmacological properties, including antitumoral potential. Ethosome dispersions were designed as systems gossypin, employing two different production procedures. The evaluation vesicle size distribution by photon correlation spectroscopy, morphology cryogenic transmission electron microscopy, gossypin entrapment capacity, well in vitro release permeation vertical diffusion cells, enabled us select a strategy based on injection phosphatidylcholine ethanolic solution water. Indeed, vesicles prepared this method almost unilamellar measured roughly 150 nm mean diameter while displaying an capacity higher than 94%. Moreover, ethanol control improve its with respect drug. To obtain semi-solid forms suitable cutaneous administration, ethosome thickened 0.5% w/w xanthan gum, selected spreadability test. These gels then further characterized small- wide-angle X-ray scattering, their antioxidant activity demonstrated radical scavenging assay. Finally, biological studies A375 melanoma cell lines. Namely, wound healing migration assays confirmed potential effect especially when loaded ethosomal gel. promising results suggest investigation gossypin-loaded gel treatment melanoma.

Язык: Английский

Polyaminoglycoside nanosystem expressing antimicrobial peptides for multistage chronic wound management

Journal of Controlled Release, Год журнала: 2025, Номер unknown, С. 113657 - 113657

Опубликована: Март 1, 2025

Язык: Английский