Progress in Organic Coatings, Год журнала: 2024, Номер 200, С. 108980 - 108980
Опубликована: Дек. 5, 2024
Язык: Английский
Materials Today Bio, Год журнала: 2025, Номер 31, С. 101557 - 101557
Опубликована: Фев. 5, 2025
Diabetic infections/wounds remain to be a threatening challenge as it seriously leads lower limb amputation with endless pains and subsequent high economic/psychosocial costs. The exceptional peroxidase-like activity of single-atom nanozymes (SAzymes) holds great promise for chemodynamic therapy (CDT) diabetic infection, but is extremely restricted by the near-neutral pH insufficient H2O2 levels in physiological conditions. Herein, we innovated hollow mesoporous molybdenum nanozyme (HMMo-zyme) featured catalytic activity, photothermal performance drug delivery properties more effective antibacterial therapeutic glucose oxidase (GOx) was encapsulated into HMMo-zyme phase-change material (PCM) form HMMo/GOx@P system, which could controllably disassembled near-infrared ray (NIR) trigger cascade CDT toward bacterial infections. results revealed that release GOx accelerated NIR facilitate continuous conversion (Glu) gluconic acid, accompanied sharply decrease establish low-pH environment notably enhanced HMMo-zyme, subsequently drives generated toxic hydroxyl radicals (·OH) amplified anti-bacterial treatment. As proof concept, this NIR-assisted strategy efficiently inhibit/kill bacteria suppress tissue inflammations, thereby accelerating wound healing processes both vitro vivo infection models. This study provides novel may serve promising alternative antibiotic therapeutics against thus holding treatment manipulating Mo-based SAzymes.
Язык: Английский
Процитировано
0
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
0
Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 18
Опубликована: Фев. 18, 2025
Diabetic wounds are difficult to treat clinically because they heal poorly, often leading severe complications such as infections and amputations. Hydrogels with smart self-healing properties show great promise for treating diabetic wounds. These hydrogels capable of continuously dynamically responding changes in the wound environment, feature improved mechanical qualities capacity self-heal damage. We explore latest developments healing this review. First, we systematically summarize obstacles then highlighted significance hydrogels, explaining their stimulus-responsive mechanisms design approaches, along applications addressing these challenges. Finally, discussed unresolved potential avenues future research. anticipate that review will facilitate continued refinement dressings, aiming broader clinical adoption.
Язык: Английский
Процитировано
0
Inorganic Chemistry Communications, Год журнала: 2025, Номер unknown, С. 114275 - 114275
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 22, 2025
Язык: Английский
Процитировано
0
Essays in Biochemistry, Год журнала: 2025, Номер 00(00)
Опубликована: Март 25, 2025
Hypertension represents a highly prevalent chronic condition and stands among the foremost contributors to premature mortality on global scale. Its etiopathogenesis is intricate multifaceted, being shaped by diverse array of elements such as age, genetic predisposition, activation neuroendocrine apparatus. Mounting evidence has shed light significant part that autoimmune responses play in hypertension ensuing damage end organs. Virtually all varieties immune cells, spanning both innate adaptive compartments, exhibit close correlation with progression hypertension. These cells infiltrate kidney vascular mesenchyme, subsequently discharging potent cytokines, reactive oxygen species, metalloproteinases. This cascade events can affect functionality local blood vessels potentially precipitate adverse structural functional alterations crucial organs like heart kidney. In recent times, management end-organ emerged pivotal scientific focus. A multitude researchers are actively engaged probing efficacious intervention regimens, which immunotherapy strategies hold considerable promise anticipation prospective avenue.
Язык: Английский
Процитировано
0
ACS Applied Nano Materials, Год журнала: 2025, Номер unknown
Опубликована: Март 27, 2025
Язык: Английский
Процитировано
0
Nanoscale Advances, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Chronic wound treatment poses a substantial challenge to healthcare systems. Certain herbal medicines have demonstrated clinical efficacy in promoting chronic healing, yet their therapeutic mechanisms at the molecular level remain elusive due complex composition and multifaceted nature. In this study, Ba-Hao ointment (BHO), sophisticated formulation with diverse ingredients, is selected as model precisely investigate its wound-healing mechanism. Network pharmacology analysis docking simulations reveal that BHO specifically interacts key proteins, including vascular endothelial growth factor A (VEGFA), tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), suggesting ability modulate critical biological pathways involved inflammation tissue regeneration. Experimental validation further demonstrates significantly promotes cell proliferation, suppresses bacterial infection, enhances expression of essential factors such epidermal (EGF) VEGFA normal human dermal fibroblasts (NHDF), all which are vital for effective healing. vivo studies confirm accelerates closure, reduces inflammation, development well-organized granulation via activation PI3K-Akt signaling pathway. This study interesting since it unveils BHO's role furthering medicine insights.
Язык: Английский
Процитировано
0
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 162627 - 162627
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Journal of Colloid and Interface Science, Год журнала: 2025, Номер unknown, С. 137696 - 137696
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0