Hybrid Cell Membrane‐Engineered Nanocarrier for Triple‐Action Strategy to Address Pseudomonas aeruginosa Infection DOI Creative Commons

Shunhao Zhang,

Tianyu Chen, Weitong Lu

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Дек. 25, 2024

Bacterial infections resistant to antimicrobial treatments, particularly those caused by Pseudomonas aeruginosa (P. aeruginosa), frequently lead elevated mortality rates. Tackling this resistance using therapeutic combinations with varied mechanisms has shown considerable promise. In study, a bioinspired nanocarrier is successfully designed and engineered for targeted antibiotic delivery toxin/bacteria clearance. This achieved encapsulating antibiotic-loaded framework nucleic acids hybrid cell membranes acquired from neutrophils platelets. By coating the membrane outside shell, nanocarriers are endowed function of neutrophil-like chemotaxis platelet-like bacteria adhesion achieve first stage inflammation targeting. Based on specific binding toxin membrane, release triggered toxin-mediated lysis fulfill second neutralization killing. Meanwhile, immunomodulation potential enables accomplish third reversing immunosuppressive microenvironment. mouse models acute chronic P. pneumonia, can reduce bacterial burden at low dosage decrease negligible toxicity. sum, these findings have illustrated remarkable capability in treating recalcitrant infections.

Язык: Английский

Current Understanding and Translational Prospects of Tetrahedral Framework Nucleic Acids DOI Creative Commons
Junjie Gu,

Jiale Liang,

Taoran Tian

и другие.

JACS Au, Год журнала: 2025, Номер 5(2), С. 486 - 520

Опубликована: Фев. 10, 2025

Tetrahedral framework nucleic acids (tFNAs) represent a promising advancement in acid nanotechnology due to their unique structural properties, high biocompatibility, and multifaceted biomedical applications. Constructed through one-pot annealing method, four single-stranded DNAs self-assemble into stable, three-dimensional tetrahedral nanostructures with enhanced mechanical robustness physiological stability, resisting enzymatic degradation. Their ability permeate mammalian cells without transfection agents, coupled modifiable surfaces, positions tFNAs as versatile carriers for drug gene delivery systems. The tFNA-based platforms exhibit superior therapeutic efficacy, including antioxidative anti-inflammatory effects, alongside efficient cellular uptake tissue penetration. These features underpin role precision medicine, enabling targeted of diverse agents such synthetic compounds, peptides, acids. Additionally, demonstrate significant potential regenerative immune modulation, antibacterial strategies, oncology. By addressing challenges translational integration, stand poised accelerate the development research clinical applications, fostering novel therapies enhancing outcomes across wide spectrum diseases. This Perspective thoroughly details attributes applications critically evaluates tFNAs' potential, outlining inherent implementation exploring solutions these obstacles.

Язык: Английский

Процитировано

2
A nanocatalytic membrane with sono-responsive antibacterial therapy (SRAT) for rapid sterilization and enhanced chronic wound healing DOI
Shuai He,

Lu Xie,

Daiquan Zhang

и другие.

Nanoscale, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

A novel PN-bioHJ membrane combining black phosphorus and barium titanate on a PLGA platform achieves >99% antibacterial efficiency under ultrasound, with excellent biocompatibility for infected tissue regeneration.

Язык: Английский

Процитировано

0
Hybrid Cell Membrane‐Engineered Nanocarrier for Triple‐Action Strategy to Address Pseudomonas aeruginosa Infection DOI Creative Commons

Shunhao Zhang,

Tianyu Chen, Weitong Lu

и другие.

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Дек. 25, 2024

Bacterial infections resistant to antimicrobial treatments, particularly those caused by Pseudomonas aeruginosa (P. aeruginosa), frequently lead elevated mortality rates. Tackling this resistance using therapeutic combinations with varied mechanisms has shown considerable promise. In study, a bioinspired nanocarrier is successfully designed and engineered for targeted antibiotic delivery toxin/bacteria clearance. This achieved encapsulating antibiotic-loaded framework nucleic acids hybrid cell membranes acquired from neutrophils platelets. By coating the membrane outside shell, nanocarriers are endowed function of neutrophil-like chemotaxis platelet-like bacteria adhesion achieve first stage inflammation targeting. Based on specific binding toxin membrane, release triggered toxin-mediated lysis fulfill second neutralization killing. Meanwhile, immunomodulation potential enables accomplish third reversing immunosuppressive microenvironment. mouse models acute chronic P. pneumonia, can reduce bacterial burden at low dosage decrease negligible toxicity. sum, these findings have illustrated remarkable capability in treating recalcitrant infections.

Язык: Английский

Процитировано

0