ACS Macro Letters, Год журнала: 2025, Номер unknown, С. 679 - 686

Опубликована: Май 9, 2025

Peptide self-assembly has been used to fabricate synthetic hydrogels that emulate many of the chemical and physical properties natural hydrogels. However, these materials often lack stability for applications do not display native bioactivity found in tissue. Here we demonstrate a hybrid hydrogel system which self-assembling peptides are integrated with polysaccharides enhance gelation provide improved mechanics bioactivity. A peptide based on tryptophan zipper (trpzip) motif was mixed anionic polysaccharide gellan gum, demonstrating within minutes increased stiffness compared trpzip alone. The material maintained viscoelastic character shear-thinning, self-healing, stress-relaxation order like collagen. All supported cell adhesion viability gum content, promoting assembly into aggregates. enhanced kinetics, stability, make them promising candidates as matrices culture reagents biofabrication syringe extrusion biological delivery.

Язык: Английский