Elaborately Engineered Aggregation‐Induced Emission Antibacterial Agents: Negligible Living Cell Invasiveness, Efficient Bacterial Biofilm Inhibition and Promoting Infected Wound Healing DOI
Zu‐Sheng Huang, Zhongda Zhang, Yiting Qiu

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Май 6, 2025

Abstract Developing versatile photosensitizers capable of selectively eliminating pathogens over normal cells is an appealing yet highly challenging task. Herein, a novel strategy by exploiting the cationic and amphiphilic synergistic mechanism introduced to synthesize four aggregation‐induced emission (AIE)‐active antibacterial (PSs) TSPy‐CH 3 , MeO‐TSPy‐Bu MeO‐TSPy‐Va MeO‐TSPy‐CH . The PSs generated both type I II reactive oxygen species (ROS) under white light irradiation. They can quickly stain Staphylococcus aureus ( S. ) in 15 min, but exhibited different Escherichia coli E.coil affinity living cell invasiveness. caused devastating killing methicillin‐resistant (MRSA) at extremely low drug doses significantly inhibited biofilm formation drug‐resistant strains photocytotoxicity inherent dark toxicity. Their concentrations minimal invasiveness toward collectively ensured biosafety. with moderate Clog P value stands out from others virtues most reliable biosafety, broad‐spectrum bactericidal performance, excellent inhibition ability. In vivo studies on bacteria‐infected wounds confirmed that reduced inflammation, promoted angiogenesis, accelerated wound recovery, achieving comparable therapeutic outcomes vancomycin. This work provides enlightenment for designing phototherapy agents overcome key limitations such as unpredictable biosafety risk, inadequate potency, poor anti‐biofilm performance.

Язык: Английский

Elaborately Engineered Aggregation‐Induced Emission Antibacterial Agents: Negligible Living Cell Invasiveness, Efficient Bacterial Biofilm Inhibition and Promoting Infected Wound Healing DOI
Zu‐Sheng Huang, Zhongda Zhang, Yiting Qiu

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Май 6, 2025

Abstract Developing versatile photosensitizers capable of selectively eliminating pathogens over normal cells is an appealing yet highly challenging task. Herein, a novel strategy by exploiting the cationic and amphiphilic synergistic mechanism introduced to synthesize four aggregation‐induced emission (AIE)‐active antibacterial (PSs) TSPy‐CH 3 , MeO‐TSPy‐Bu MeO‐TSPy‐Va MeO‐TSPy‐CH . The PSs generated both type I II reactive oxygen species (ROS) under white light irradiation. They can quickly stain Staphylococcus aureus ( S. ) in 15 min, but exhibited different Escherichia coli E.coil affinity living cell invasiveness. caused devastating killing methicillin‐resistant (MRSA) at extremely low drug doses significantly inhibited biofilm formation drug‐resistant strains photocytotoxicity inherent dark toxicity. Their concentrations minimal invasiveness toward collectively ensured biosafety. with moderate Clog P value stands out from others virtues most reliable biosafety, broad‐spectrum bactericidal performance, excellent inhibition ability. In vivo studies on bacteria‐infected wounds confirmed that reduced inflammation, promoted angiogenesis, accelerated wound recovery, achieving comparable therapeutic outcomes vancomycin. This work provides enlightenment for designing phototherapy agents overcome key limitations such as unpredictable biosafety risk, inadequate potency, poor anti‐biofilm performance.

Язык: Английский

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