Physical stimuli-responsive DNA hydrogels: design, fabrication strategies, and biomedical applications DOI Creative Commons

Rumi Acharya,

Sayan Deb Dutta,

H. Mallik

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 22, 2025

Physical stimuli-responsive DNA hydrogels hold immense potential for tissue engineering due to their inherent biocompatibility, tunable properties, and capacity replicate the mechanical environment of natural tissue, making physical a promising candidate engineering. These can be tailored respond specific triggers such as temperature, light, magnetic fields, ultrasound, force, electrical stimuli, allowing precise control over behavior. By mimicking extracellular matrix (ECM), provide structural support, biomechanical cues, cell signaling essential regeneration. This article explores various stimuli incorporation into hydrogels, including self-assembly hybrid hydrogel methods. The aim is demonstrate how in conjunction with other biomolecules ECM environment, generate dynamic scaffolds that facilitate We investigate most recent developments cancer therapies, injectable bone regeneration, personalized scaffolds, culture models drug discovery. study concludes by delineating remaining obstacles future orientations optimization design regeneration reconstruction tissue. It also addresses strategies surmounting current challenges incorporating more sophisticated technologies, thereby facilitating clinical translation these innovative hydrogels.

Язык: Английский

Physical stimuli-responsive DNA hydrogels: design, fabrication strategies, and biomedical applications DOI Creative Commons

Rumi Acharya,

Sayan Deb Dutta,

H. Mallik

и другие.

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Март 22, 2025

Physical stimuli-responsive DNA hydrogels hold immense potential for tissue engineering due to their inherent biocompatibility, tunable properties, and capacity replicate the mechanical environment of natural tissue, making physical a promising candidate engineering. These can be tailored respond specific triggers such as temperature, light, magnetic fields, ultrasound, force, electrical stimuli, allowing precise control over behavior. By mimicking extracellular matrix (ECM), provide structural support, biomechanical cues, cell signaling essential regeneration. This article explores various stimuli incorporation into hydrogels, including self-assembly hybrid hydrogel methods. The aim is demonstrate how in conjunction with other biomolecules ECM environment, generate dynamic scaffolds that facilitate We investigate most recent developments cancer therapies, injectable bone regeneration, personalized scaffolds, culture models drug discovery. study concludes by delineating remaining obstacles future orientations optimization design regeneration reconstruction tissue. It also addresses strategies surmounting current challenges incorporating more sophisticated technologies, thereby facilitating clinical translation these innovative hydrogels.

Язык: Английский

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