Microenvironment-adaptive nanomedicine MXene promotes flap survival by inhibiting ROS cascade and endothelial pyroptosis

Journal of Nanobiotechnology, Год журнала: 2025, Номер 23(1)

Опубликована: Апрель 7, 2025

In the field of large-area trauma flap transplantation, preventing avascular necrosis remains a critical challenge. Key mechanisms for improving viability include angiogenesis promotion, oxidative stress inhibition, and cell death prevention. Recently, two-dimensional ultrathin Ti3C2TX (MXene) nanosheets have gained attention their potential contributions to these processes, though MXene's physiological impact on survival had not been previously investigated. This study is first confirm biological effects ischaemic microenvironment post-skin transplantation. Findings indicated that MXene significantly decreased necrotic area in flaps (37.96% ± 2.00%), with reductions 30.40% 1.86% at 1 mg/mL 20.19% 2.11% 2 concentration-dependent manner. Mechanistically, facilitated situ angiogenesis, mitigated stress, suppressed pro-inflammatory pyroptosis, activated PI3K-Akt pathway, particularly influencing vascular endothelial cells. Comparative transcriptome analysis skin tissues without treatment provided additional evidence, highlighting such as ROS metabolic proliferation regulation, signaling pathway activation. Overall, demonstrated activity, effectively promoting presenting novel strategy addressing flaps.

Язык: Английский

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MXene and prostate cancer: is there promising news?

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 14

Опубликована: Апрель 16, 2025

Prostate cancer is the most prevalent among men worldwide, and there have been many advances in its diagnosis treatment. However, critical obstacles remain, including overdiagnosis, high rates of negative biopsies, management side effects, timely detection relapse. Despite these improvements, surgery radiotherapy are still associated with a significant risk short- or long-term effects. MXenes novel class two-dimensional nanomaterials manufactured through electrochemical procedures that accept wide-termination hydrophilic molecules as surface modifications. The importance MXene has increased owing to aspects, such high-gain synthesis potential, chemical flexibility, biocompatibility. Hence, convenient nanomaterial can be modified synthesized different models, suggesting ability improve screening, diagnosis, theranostic applications, thermal therapy. These features used detect potential urothelial tumor markers well direction accumulation medications target tissue.

Язык: Английский

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In Situ and Real‐Time Multi‐Modality Imaging Guided Orderly Triple‐Therapy of Tumors with a Multifunctional Nanodrug

Advanced Science, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Abstract Effective integration of different therapeutic methods is a promising way to improve the overall efficacy tumor therapy, which needs be guided by in situ and real‐time monitoring each process. Here multifunctional AuNR@SiO 2 @MnO @DNA prodrugs (ASMD) nanodrug designed for orderly photothermal therapy (PTT)/chemodynamic (CDT)/gene (GT) triple‐therapy tumors, can photoacoustic (PA)/magnetic resonance (MR)/fluorescence (FL) multi‐modality imaging. The gold nanorod ASMD generate PA signal perform PTT. MnO respond glutathione inside cells release Mn 2+ , MR CDT catalyzing degradation intracellular H O · OH. DNA cascade response presence released microRNA 21, turn on quenched FL small‐interfering RNA antisense oligonucleotide GT. Guiding PA/MR/FL imaging process, an PTT/CDT/GT tumors established, provides significant strategy develop more efficient practical programs tumors.

Язык: Английский

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In-Vitro Anti-cancer Therapeutic Effects of 2D-Ti3C2-MXene-Coated Hesperetin (Ti3C2_H) against Cervical Cancer Cells

Journal of Inorganic and Organometallic Polymers and Materials, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

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