Bioinspired Protein‐Mineralized Single‐Atom Nanozymes for Tumor‐Specific Cascade Therapy via Self‐Amplifying Catalytic Synergy DOI
Haiyan Li, Yuan-Yuan Zhang, Qian Zhao

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Май 28, 2025

Abstract Single‐atom catalysts (SACs) are highly promising in biomedical applications due to their unmatched catalytic activity and atomic‐level precision, yet clinical translation is hindered by limited biocompatibility, instability, lack of tumor targeting. Here, a universal, bioinspired strategy proposed construct flexible, biocompatible SACs leveraging enzymatic protein scaffolds for mineralization single‐atom platinum (Pt). This protein‐mineralized platform enables the fabrication stable dual‐functional nanozymes, exemplified glucose oxidase‐coordinated Pt (GOx‐Pt), which simultaneously catalyze oxidation H₂O₂‐to‐•OH conversion, generating self‐amplifying cascade reactive oxygen species (ROS) production. To ensure specificity, GOx‐Pt nanozyme encapsulated within pH‐responsive zeolitic imidazolate framework (ZIF‐8), remains under physiological conditions but disintegrates mildly acidic environments, enabling localized selective therapeutic activation. synergistic design not only enhances antitumor efficacy inducing oxidative stress depletion also minimizes systemic toxicity. The resulting ZIF‐8@GOx‐Pt system achieves robust stability, cytotoxicity, significant inhibition (53%) vivo without discernible side effects. work pioneers versatile biomineralization approach engineering SAC‐based nanozymes with dual tumor‐responsive functions, offering generalizable next‐generation precision cancer therapeutics.

Язык: Английский

In-Depth First-Principles Study of High-Performance M2XO2 MXene Cathode Catalysts for Sodium-Oxygen Batteries DOI Open Access
Lianming Zhao,

Z.N. Jiang,

Tao Ding

и другие.

Catalysts, Год журнала: 2025, Номер 15(4), С. 311 - 311

Опубликована: Март 25, 2025

Na−O2 batteries are plagued by high cathodic oxygen reduction (ORR)/oxygen evolution (OER) overpotentials during discharging/charging. Herein, we constructed six carbide/nitride MXenes (M2XO2, M = Ti, Zr, and Hf, X C, N) investigated their performance as cathodes for first-principles calculations. M2CO2 have a pseudogap, showing semiconducting properties, while M2NO2 conductive. The nucleophilic O on the M2XO2 surfaces prefers to bind with Na atoms of NaxO2 intermediates activate Na−O bonds, improving sodium deintercalation. For all MXenes, OER overpotential is higher than ORR overpotential, forming bottleneck batteries. originate from too-strong adsorption MXenes. Lowering p-band center can weaken adsorption, thereby reducing overpotential. Consequently, carbides lower those nitrides further decrease decreasing atomic number. Ti2CO2 MXene shows extremely low ORR, OER, total (0.23, 0.32, 0.55 V), suggesting huge potential in

Язык: Английский

Процитировано

0
First-Principles Investigation into Synergetic Effect of Functional Groups on Enhancing Catalytic Performance of Mxene-Based Single Atom Catalysts Towards Co2rr DOI
Jie Yu,

Yabing Zeng,

Junyao Chen

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
First-principles investigation into influence of exotic functional groups on enhancing catalytic performance of MXene-based single atom catalysts towards CO2RR DOI
Jie Yu,

Yabing Zeng,

Junyao Chen

и другие.

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 697, С. 137961 - 137961

Опубликована: Май 21, 2025

Язык: Английский

Процитировано

0
Bioinspired Protein‐Mineralized Single‐Atom Nanozymes for Tumor‐Specific Cascade Therapy via Self‐Amplifying Catalytic Synergy DOI
Haiyan Li, Yuan-Yuan Zhang, Qian Zhao

и другие.

Small, Год журнала: 2025, Номер unknown

Опубликована: Май 28, 2025

Abstract Single‐atom catalysts (SACs) are highly promising in biomedical applications due to their unmatched catalytic activity and atomic‐level precision, yet clinical translation is hindered by limited biocompatibility, instability, lack of tumor targeting. Here, a universal, bioinspired strategy proposed construct flexible, biocompatible SACs leveraging enzymatic protein scaffolds for mineralization single‐atom platinum (Pt). This protein‐mineralized platform enables the fabrication stable dual‐functional nanozymes, exemplified glucose oxidase‐coordinated Pt (GOx‐Pt), which simultaneously catalyze oxidation H₂O₂‐to‐•OH conversion, generating self‐amplifying cascade reactive oxygen species (ROS) production. To ensure specificity, GOx‐Pt nanozyme encapsulated within pH‐responsive zeolitic imidazolate framework (ZIF‐8), remains under physiological conditions but disintegrates mildly acidic environments, enabling localized selective therapeutic activation. synergistic design not only enhances antitumor efficacy inducing oxidative stress depletion also minimizes systemic toxicity. The resulting ZIF‐8@GOx‐Pt system achieves robust stability, cytotoxicity, significant inhibition (53%) vivo without discernible side effects. work pioneers versatile biomineralization approach engineering SAC‐based nanozymes with dual tumor‐responsive functions, offering generalizable next‐generation precision cancer therapeutics.

Язык: Английский

Процитировано

0