Small, Год журнала: 2025, Номер unknown

Опубликована: Апрель 26, 2025

Abstract Photodynamic therapy (PDT) represents a high‐efficient and non‐invasive therapeutic modality for current future tumor treatments, drawing extensive attention in the fields of antitumor drug clinical phototherapy. In recent years, photosensitizer (PS) market PDT applications have expanded to address various cancers skin diseases. However, hypoxic environment within tumors poses substantial challenge capability reactive oxygen species‐dependent PDT. Consequently, researches increasingly focus from type II I mechanism, which relies on radical production with less or no dependence. Despite significant progress development PSs, holistic understanding regarding design principles these molecules remains elusive. Specifically, electron transfer‐mediated are extensively studied years but is insufficiently addressed existing reviews. This review systematically summarizes advancements molecular rationales organic categorizing them into three key fundamental strategies: modulating PS charge distribution, singlet forbidden via low triplet excited state, accelerating formation inducing transfer. aims offer valuable insights advancement anti‐hypoxia

Язык: Английский