Enhanced hydrogel loading of quercetin-loaded hollow mesoporous cerium dioxide nanoparticles for skin flap survival

Materials Today Bio, Год журнала: 2024, Номер 30, С. 101432 - 101432

Опубликована: Дек. 28, 2024

Flap techniques are indispensable in modern surgery because of their role repairing tissue defects and restoring function. Ischemia-reperfusion oxidative stress-induced injuries the main causes flap failure. Oxidative stress exacerbates cell damage through accumulation reactive oxygen species (ROS), thereby affecting function survival. Effective management these factors is essential for improving survival post-operative recovery. In this study, we utilized hollow mesoporous cerium dioxide nanoparticles loaded with quercetin, which were later into a light-cured double cross-linked hydrogel (HQu@BC) injected site to activate macrophage reprogramming maintain local ROS homeostasis reduce inflammation. Quercetin scavenges reduces mitochondrial due its intrinsic reducing structures such as catechols, carbon-carbon bonds, hydroxyl synergistic nanoparticles, inhibits inflammation by suppressing M1 polarization. This system continuously regulates levels, kills bacteria ultimately inflammation, creating favorable microenvironment innovative injectable composite nanoparticle material has anti-inflammatory, antioxidant, antimicrobial, healing-promoting properties, providing new approach success surgery.

Язык: Английский

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Osteoblastic Cell Sheet Engineering Using P(VCL-HEMA)-Based Thermosensitive Hydrogels Doped with pVCL@Icariin Nanoparticles Obtained with Supercritical CO2-SAS

Pharmaceutics, Год журнала: 2024, Номер 16(8), С. 1063 - 1063

Опубликована: Авг. 13, 2024

New clinical strategies for treating severe bone and cartilage injuries are required, especially use in combination with implant procedures. For this purpose, p(VCL-co-HEMA) thermosensitive hydrogels have been activated icariin-loaded nanoparticles to be used as bone-cell-harvesting platforms. Supercritical CO2-SAS technology has applied encapsulate icariin, a small molecule that is involved osteoblastic differentiation. Thus, physical-chemical analysis, including swelling transmittance, showed the impact of HEMA groups hydrogel composition. Moreover, icariin (ICA) release from platforms, pVCL@ICA nanoparticles, studied evaluate their efficacy relevant conditions. Finally, hydrogels’ cell compatibility, transplant efficiency, differentiation capacity were tested. This study identifies optimal formulations icariin-activated both control formulations. Using technique, sheets rich collagen type I successfully transplanted recultivated, maintaining an extracellular matrix (ECM) These findings suggest new cell-sheet-based therapy regeneration purposes using customized NP-activated pVCL-based

Язык: Английский

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Introductory Review of Soft Implantable Bioelectronics Using Conductive and Functional Hydrogels and Hydrogel Nanocomposites

Gels, Год журнала: 2024, Номер 10(10), С. 614 - 614

Опубликована: Сен. 25, 2024

Interfaces between implantable bioelectrodes and tissues provide critical insights into the biological pathological conditions of targeted organs, aiding diagnosis treatment. While conventional bioelectronics, made from rigid materials like metals silicon, have been essential for recording signals delivering electric stimulation, they face limitations due to mechanical mismatch devices soft tissues. Recently, focus has shifted toward conductive materials, such as hydrogels hydrogel nanocomposites, known their tissue-like softness, biocompatibility, potential functionalization. This review introduces these provides an overview recent advances in nanocomposites electronics. It covers material strategies hydrogels, including both intrinsically explores key functionalization techniques biodegradation, bioadhesiveness, injectability, self-healing. Practical applications electronics are also highlighted, showcasing effectiveness real-world scenarios. Finally, we discuss emerging technologies future needs chronically offering evolving landscape this field.

Язык: Английский

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Injectable bioresponsive bone adhesive hydrogels inhibit NLRP3 inflammasome on demand to accelerate diabetic fracture healing

Biomaterials, Год журнала: 2024, Номер 317, С. 123059 - 123059

Опубликована: Дек. 26, 2024

Язык: Английский

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Developing biotechnologies in organoids for liver cancer

Biomedical Technology, Год журнала: 2024, Номер 9, С. 100067 - 100067

Опубликована: Ноя. 26, 2024

Язык: Английский

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