Опубликована: Янв. 1, 2024
Язык: Английский
Smart Molecules, Год журнала: 2025, Номер unknown
Опубликована: Янв. 5, 2025
Abstract Cellular senescence is a steady state of cell cycle arrest necessary to maintain homeostasis in organisms. However, senescent cells may cause neighboring healthy cells, inducing the onset several diseases, such as inflammation, neurological disorders, and atherosclerosis. Therefore, early detection cellular extremely important. β‐Galactosidase (β‐gal), critical marker senescence, can be monitored facilitate diagnosis aging‐related diseases. Furthermore, β‐gal mainly found lysosomes, which have pH value about 4.5–5.5. Here, we developed near‐infrared fluorescent probe (QMOH‐Gal) for tracking vitro vivo via β‐gal. In addition, displayed high sensitivity specificity with good fluorescence signal acidity range. Subsequently, this QMOH‐Gal was successfully employed differentiate between normal by monitoring not only realized zebrafish but also palbociclib‐induced breast tumor senescence. Overall, shows great promise an effective tool imaging studying biology aging
Язык: Английский
Процитировано
1
Critical Reviews in Analytical Chemistry, Год журнала: 2025, Номер unknown, С. 1 - 21
Опубликована: Фев. 19, 2025
Manganese is an essential metal ion involved in various biological and environmental processes, but its excess can lead to toxicity, particularly affecting the nervous system. Therefore, developing selective sensitive detection methods for Mn2+ ions of paramount importance. Colorimetric fluorimetric chemosensors have emerged as promising tools due their simplicity, cost-effectiveness, real-time monitoring capabilities. This review discusses recent advances colorimetric that exhibit distinct color or fluorescence changes upon interaction with ions. The explores different organic nanomaterials, focusing on mechanisms sensing, sensitivity, selectivity, practical applications monitoring, healthcare, food safety. article also provides insights into future research directions aimed at overcoming these challenges, improving chemosensor performance, expanding applicability diverse real-world scenarios.
Язык: Английский
Процитировано
1
Coordination Chemistry Reviews, Год журнала: 2025, Номер 529, С. 216471 - 216471
Опубликована: Янв. 28, 2025
Язык: Английский
Процитировано
0
Chemical Physics, Год журнала: 2025, Номер 593, С. 112641 - 112641
Опубликована: Фев. 7, 2025
Язык: Английский
Процитировано
0
Analytical Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 13, 2025
As a highly aggressive malignancy, the issue of curing melanoma at an advanced stage could suffer from severe metastasis and lower 5-year survival rate. Therefore, early diagnosis with high accuracy is vital contributes to significantly improved This work reports dual-locked receptor, m-BA-Hcy, which releases near-infrared (NIR) fluorophore Hcy–OH upon dual activation reactive oxygen species (ROS) tyrosinase (TYR). The substitution boric acid on phenyl ring was studied, influences feasibility performance envisaged cascade reaction. sensing behavior discussed in terms optical spectroscopy reaction mechanism, imaging fully performed cellular organism levels. Receptor m-BA-Hcy hence clarified possess supreme sensitivity for detection.
Язык: Английский
Процитировано
0
Sensors and Actuators B Chemical, Год журнала: 2025, Номер 433, С. 137519 - 137519
Опубликована: Фев. 28, 2025
Язык: Английский
Процитировано
0
ACS Sensors, Год журнала: 2025, Номер unknown
Опубликована: Март 10, 2025
The development and practical applications of multifunctional organic fluorophores have garnered significant attention in translational research recent years. Among the fluorophores, nitrobenzodioxazole (NBD) has been widely used various fields due to its small size neutral character, both which are advantageous for biorelated applications. However, NBD presents some limitations, including (1) suboptimal photophysical properties vivo (2) monofunctional nature, restricts use fluorescence-based bioimaging sensing. To overcome these challenges, focused on nitrobenzoselenadiazole (NBSD) derivatives, a selenium analog NBD. In this review article, we systematically summarize advancements NBSD highlight examples application as fluorophore. We also explore potential present representative case studies, providing valuable context ongoing new derivatives field fluorophore-related material science.
Язык: Английский
Процитировано
0
Analytical Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Март 24, 2025
Hydrogen peroxide (H2O2) plays a vital role in various physiological and pathological processes. Thus, fluorescent probes of H2O2 are powerful tools for the investigation H2O2-related diseases. However, developing that do not irreversibly consume presents significant challenge. In this work, we introduce carbonate ester as nonconsumptive recognizing molecule to construct RES-6C novel probe H2O2. exhibited selective sensitive turn-on fluorescence response H2O2, enabling detection cells without disturbing cellular redox status. has been applied study nonalcoholic fatty liver disease, revealing peroxisomes mitochondria contribute production similar extent during very-long-chain acid metabolism first time. It also enabled imaging LPS-induced inflammation mouse model. Overall, serves versatile tool monitor tissues vivo, providing new insights into design
Язык: Английский
Процитировано
0
Sensors and Actuators A Physical, Год журнала: 2025, Номер unknown, С. 116558 - 116558
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0
Sensors and Actuators B Chemical, Год журнала: 2025, Номер unknown, С. 137774 - 137774
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0