Therapeutic Potential of Microneedle Assisted Drug Delivery for Wound Healing: Current State of the Art, Challenges, and Future Perspective
AAPS PharmSciTech,
Год журнала:
2025,
Номер
26(1)
Опубликована: Янв. 8, 2025
Язык: Английский
Emerging Trends in Dissolving-Microneedle Technology for Antimicrobial Skin-Infection Therapies
Rui Luo,
Huihui Xu,
Qiaoni Lin
и другие.
Pharmaceutics,
Год журнала:
2024,
Номер
16(9), С. 1188 - 1188
Опубликована: Сен. 8, 2024
Skin
and
soft-tissue
infections
require
significant
consideration
because
of
their
prolonged
treatment
duration
propensity
to
rapidly
progress,
resulting
in
severe
complications.
The
primary
challenge
stems
from
the
involvement
drug-resistant
microorganisms
that
can
form
impermeable
biofilms,
as
well
possibility
infection
extending
deep
into
tissues,
thereby
complicating
drug
delivery.
Dissolving
microneedle
patches
are
an
innovative
transdermal
drug-delivery
system
effectively
enhances
penetration
through
stratum
corneum
barrier,
increasing
concentration
at
site
infection.
They
offer
highly
efficient,
safe,
patient-friendly
alternatives
conventional
topical
formulations.
This
comprehensive
review
focuses
on
recent
advances
emerging
trends
dissolving-microneedle
technology
for
antimicrobial
skin-infection
therapy.
Conventional
antibiotic
microneedles
compared
with
those
based
agents,
such
quorum-sensing
inhibitors,
peptides,
antimicrobial-matrix
materials.
also
highlights
potential
incorporating
chemodynamic,
nanoenzyme
antimicrobial,
photodynamic,
photothermal
antibacterial
therapies.
explores
advantages
various
therapies
emphasizes
combined
application
improve
efficacy
microneedles.
Finally,
this
analyzes
druggability
different
discusses
possible
future
developments.
Язык: Английский
Engineered Microneedle System Enables the Smart Regulation of Nanodynamic Sterilization and Tissue Regeneration for Wound Management
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 13, 2025
Abstract
The
healing
of
bacterial
biofilm‐infected
wounds
is
a
complex
process,
and
the
construction
emerging
therapeutic
modalities
that
regulate
microenvironment
to
magnify
effects
reduce
biotoxicity
still
highly
challenging.
Herein,
an
engineered
microneedle
(MN)
patch
reported
mediate
efficient
delivery
black
phosphorus
nanosheets
(BP
NSs)
copper
peroxide
nanodots
(CP
NDs)
for
dual
nanodynamic
sterilization
methicillin‐resistant
staphylococcus
aureus
(MRSA)‐infected
wound
healing.
Results
demonstrate
system
can
eliminate
biofilm,
cytotoxicity,
promote
angiogenesis
tissue
regeneration
by
multiple
advantages
chemodynamic
therapy
(CDT),
enhanced
photodynamic
(PDT),
improved
degradation
process
from
BP
NSs
phosphate
promoting
cell
proliferation.
Notably,
balance
between
excellent
stability
rapid
degradability
maintained,
mechanism
vividly
elucidated
density
functional
theory
(DFT)‐based
molecular
dynamics
(MD)
calculations.
Furthermore,
transcriptional
changes
treated
MRSA‐infected
skin
are
studied
using
RNA‐seq
technology
reveal
potential
mechanism.
As
envisaged,
proposed
MN
provides
safe,
easy,
also
effective
approach
achieve
temporal
regulation
wounds.
Язык: Английский
Dissolving Microneedles Embedded with Photosensitizers for Targeted Eradication of Gram‐Positive Bacteria in Multidrug‐Resistant Biofilms in Diabetic Wound Infections
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Abstract
Chronic
nonhealing
wounds,
common
in
diabetic
patients,
represent
a
major
clinical
challenge,
causing
significant
morbidity
and
healthcare
costs.
Persistent
bacterial
biofilms
are
critical
obstacle
to
wound
healing,
necessitating
their
effective
elimination
promote
rapid
recovery.
In
photodynamic
antimicrobial
therapy
(PDAT),
enhancing
the
interaction
between
photosensitizer
is
key
achieving
efficient
antibiofilm
effects.
Here,
novel
dissolvable
microneedle
patch
containing
benzoxaborole
(
BOB
)‐functionalized
designed,
TPI‐BOB
,
for
bacteria‐specific
targeting
localized
PDAT
of
multidrug‐resistant
biofilm
infections
wounds.
integrates
moiety
selective
binding
pyridine‐based
cationic
group
enhance
electrostatic
interactions,
showing
superior
activity
Gram‐positive
bacteria,
particularly
MRSA
.
To
further
optimize
therapeutic
delivery
combat
biofilm‐associated
infections,
incorporated
into
microneedles,
which
rapidly
disintegrate
upon
application
sites.
This
system
facilitates
localized,
biofilms,
where
it
triggers
action
under
white‐light
irradiation.
treatment
eradicates
biofilm,
initiating
tissue
repair
that
reduces
inflammation,
promotes
collagen
deposition,
stimulates
angiogenesis,
accelerating
healing.
work
presents
strategy
combining
with
microneedle‐mediated
drug
delivery,
offering
promising
approach
treating
wounds
other
biofilm‐related
infections.
Язык: Английский
Hierarchically structured conductive hydrogels for electrically programmable drug delivery in a diabetic wound healing electronic patch
Zhe-Wei Lin,
Yo-Lin Chen,
Wan‐Lou Lei
и другие.
Journal of Controlled Release,
Год журнала:
2025,
Номер
unknown, С. 113760 - 113760
Опубликована: Апрель 1, 2025
Язык: Английский
Integrated 3D-Printed Hollow Microneedle Array and Lateral Flow Immunoassay for Point-of-Care Wound Healing Monitoring
Analytical Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 17, 2024
Chronic
wound
management
requires
continuous
monitoring
to
assess
healing
and
guide
treatment.
We
developed
a
hollow
microneedle
array
patch
integrated
with
lateral
flow
immunoassay
strip
address
the
need
for
convenient,
home-based
diagnostics.
This
device
extracts
exudate
directly
from
matrix,
overcoming
limitations
of
conventional
swab
sampling,
which
relies
on
surface
collection.
The
provides
minimally
invasive,
rapid
solution
phase.
delivers
colorimetric
signal
visible
naked
eye,
facilitating
straightforward
interpretation
by
clinicians
within
10
min.
In
clinical
study
involving
90
patients,
matrix
metalloproteinase
8
(MMP-8)
was
identified
as
critical
biomarker,
achieving
80.3%
sensitivity
in
detecting
proliferative
A
specific
MMP-8
detection
limit
0.7
ng/mL,
lower
than
threshold
level
phase
(164.7
ng/mL).
3D-printed
cost-efficiency
(less
€0.10
per
patch)
height
865
±
6
μm,
allowing
painless,
easy
sampling.
Mechanical
tests
confirmed
durability
patch,
while
cytotoxicity
assays
demonstrated
its
biocompatibility.
Prevalidation
using
an
Язык: Английский