Nanotheranostics Revolutionizing Gene Therapy: Emerging Applications in Gene Delivery Enhancement

Journal of Nanotheranostics, Год журнала: 2025, Номер 6(2), С. 10 - 10

Опубликована: Апрель 9, 2025

Nanotheranostics—where nanoscale materials serve both diagnostic and therapeutic functions—are rapidly transforming gene therapy by tackling critical delivery challenges. This review explores the design engineering of various nanoparticle systems (lipid-based, polymeric, inorganic, hybrid) to enhance stability, targeting, endosomal escape genetic payloads. We discuss how real-time imaging capabilities integrated into these platforms enable precise localization controlled release genes, improving treatment efficacy while reducing off-target effects. Key strategies overcome barriers (such as proton sponge effect photothermal disruption) achieve nuclear are highlighted, along with recent advances in stimuli-responsive that facilitate spatiotemporal control expression. Clinical trials preclinical studies demonstrate expanding role nanotheranostics managing cancer, inherited disorders, cardiovascular neurological diseases. further address regulatory manufacturing hurdles must be for widespread clinical adoption nanoparticle-based therapies. By synthesizing progress ongoing challenges, this underscores transformative potential effective, targeted, image-guided delivery.

Язык: Английский

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Lipid-based nanoparticles for nucleic acids delivery

Physical Sciences Reviews, Год журнала: 2025, Номер unknown

Опубликована: Март 4, 2025

Abstract This chapter highlights challenges and advancements in the production of lipid-based nanoparticles (LNPs) their application nucleic acid-based therapies. Recently, mRNA-based vaccines for COVID-19 immunization revealed that use acids is a promising strategy to develop treatments at high therapeutic efficiency reduced side effects. In this context, LNPs emerged as favourable vehicles delivery (like mRNA DNA), due biocompatibility, bioavailability, versatility. The four main components employed produce loaded with are: cationic or ionizable lipids, helper cholesterol, PEGylated lipids. Several conventional techniques have been proposed over years kind nanoparticles. However, they show many drawbacks hinder direct vesicles characterized by nanometric size, encapsulation active pharmaceutical ingredient, prolonged stability. Processes assisted supercritical fluids (in particular, CO 2 ) can represent sustainable interesting alternative without using post-processing steps solvent removal size reduction are time-consuming procedures, lead large loss acids, negatively influence general productivity process.

Язык: Английский

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Recent Trends in Drug Delivery Systems

Assay and Drug Development Technologies, Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

Drug delivery systems are now being advanced by integrating sophisticated nanotechnologies to enhance therapeutic efficacy. Tremendous advancement has been achieved in the field of cancer therapy through utilization hyaluronic acid-based nanocarriers, which well-acknowledged for their capacity transport medication precisely targeted regions. Quantum dots exhibit unique optical properties that allow precise drug administration and monitoring capabilities. Carbon nanotubes provide a large surface area exceptional strength, allowing manipulation patterns. Dendrimers versatile structures can many drugs simultaneously, whereas mesoporous silica-functionalized nanoparticles exact release rate pharmaceuticals. Polymer-lipid hybrid synergistically integrate durability polymers with compatibility lipids, hence augmenting availability within body. Hexagonal boron nitride nanosheets becoming more recognized as favorable carriers due biocompatibility potential tailored administration. These achievements demonstrate changes happening pharmaceutical administration, where nanotechnology is used tackle issues such restricted bioavailability unanticipated adverse effects. This ultimately enhances effectiveness medicines improves patient outcomes. Future investigations will focus on improving these technologies broader applications.

Язык: Английский

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Polyethyleneimine-modified Laminarin nanoparticles as a novel vaccine adjuvant for ovalbumin to enhance the immune responses

International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 139157 - 139157

Опубликована: Дек. 1, 2024

Язык: Английский

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