Organ-on-a-chip: quo vademus? Applications and regulatory status DOI Creative Commons
Maria Mendes, Ana Sofia Morais,

A Carlos

и другие.

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 249, С. 114507 - 114507

Опубликована: Янв. 8, 2025

Organ-on-a-chip systems, also referred to as microphysiological systems (MPS), represent an advance in bioengineering microsystems designed mimic key aspects of human organ physiology and function. Drawing inspiration from the intricate hierarchical architecture body, these innovative platforms have emerged invaluable vitro tools with wide-ranging applications drug discovery development, well enhancing our understanding disease physiology. The facility replicate tissues within physiologically relevant three-dimensional multicellular environments empowers organ-on-a-chip versatility throughout different stages development process. Moreover, can be tailored specific states, facilitating investigation progression, responses, potential therapeutic interventions. In particular, they demonstrate, early-phase pre-clinical studies, safety toxicity profiles compounds. Furthermore, play a pivotal role evaluation efficacy modeling diseases. One most promising prospects technology is simulate pathophysiology subpopulations even individual patients, thereby being used personalized medicine. By mimicking physiological responses diverse patient groups, hold promise revolutionizing strategies, guiding them towards intervention unique needs each patient. This review presents status evolution microfluidic that facilitated transition cells organs recreated on chips some opportunities offered by technology. Additionally, current future perspectives challenges this still faces are discussed.

Язык: Английский

Organ-on-a-chip: quo vademus? Applications and regulatory status DOI Creative Commons
Maria Mendes, Ana Sofia Morais,

A Carlos

и другие.

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер 249, С. 114507 - 114507

Опубликована: Янв. 8, 2025

Organ-on-a-chip systems, also referred to as microphysiological systems (MPS), represent an advance in bioengineering microsystems designed mimic key aspects of human organ physiology and function. Drawing inspiration from the intricate hierarchical architecture body, these innovative platforms have emerged invaluable vitro tools with wide-ranging applications drug discovery development, well enhancing our understanding disease physiology. The facility replicate tissues within physiologically relevant three-dimensional multicellular environments empowers organ-on-a-chip versatility throughout different stages development process. Moreover, can be tailored specific states, facilitating investigation progression, responses, potential therapeutic interventions. In particular, they demonstrate, early-phase pre-clinical studies, safety toxicity profiles compounds. Furthermore, play a pivotal role evaluation efficacy modeling diseases. One most promising prospects technology is simulate pathophysiology subpopulations even individual patients, thereby being used personalized medicine. By mimicking physiological responses diverse patient groups, hold promise revolutionizing strategies, guiding them towards intervention unique needs each patient. This review presents status evolution microfluidic that facilitated transition cells organs recreated on chips some opportunities offered by technology. Additionally, current future perspectives challenges this still faces are discussed.

Язык: Английский

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