ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(15), С. 19472 - 19479
Опубликована: Апрель 4, 2024
Nanomedicine-enhanced
immunogenic
cell
death
(ICD)
has
attracted
considerable
attention
for
its
great
potential
in
cancer
treatment.
Even
though
polyethylene
glycol
(PEG)
is
widely
recognized
as
the
gold
standard
surface
modification
of
nanomedicines,
some
shortcomings
associated
with
this
PEGylation,
such
hindered
endocytosis
and
accelerated
blood
clearance
phenomenon,
have
been
revealed
recent
years.
Notably,
polysarcosine
(PSar)
a
highly
biocompatible
polymer
can
be
finely
synthesized
by
mild
ring-opening
polymerization
(ROP)
sarcosine
N-carboxyanhydrides
(Sar-NCAs)
exhibit
an
alternative
to
PEG.
In
article,
PSar-b-polycamptothecin
block
copolymers
are
sequential
ROP
camptothecin-based
NCAs
(CPT-NCAs)
Sar-NCAs.
Then,
detailed
systematic
comparison
between
PEGylation
PSarylation
against
4T1
tumor
model
indicates
that
PSar
decoration
facilitate
endocytosis,
greatly
enhancing
ICD
effects
antitumor
efficacy.
Therefore,
it
believed
well-developed
technique
will
achieve
effective
precise
treatment
near
future.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Sonodynamic
therapy
(SDT),
which
is
non-invasive
and
controllable
has
the
potential
to
treat
triple-negative
breast
cancer
(TNBC).
However,
hypoxia
immunosuppressive
tumor
microenvironment
(TME)
often
block
production
of
reactive
oxygen
species
induction
SDT-activated
immunogenic
cell
death,
thus
limiting
activation
adaptive
immune
responses.
To
alleviate
these
challenges,
we
proposed
development
a
multifunctional
biomimetic
nanoplatform
(mTSeIR),
was
designed
with
diselenide-conjugated
sonosensitizers
tirapazamine
(TPZ),
encapsulated
within
M1
macrophage
membrane.
This
utilized
hypoxia-induced
chemotherapy
improve
efficacy
SDT,
further
enhance
immunotherapy
by
activating
innate
immunity
remodeling
TME.
Firstly,
prodrug
TPZ
activated
due
increased
consumption
associated
SDT.
Subsequently,
mTSeIR
enhanced
repolarization
M2
macrophages
phenotype.
The
diselenide
component
in
effectively
natural
killer
cell-mediated
antitumor
response.
Ultimately,
vivo
studies
indicated
that
mTSeIR+US
good
biosafety
achieved
over
98%
inhibition
immunotherapy.
research
presents
an
efficient
approach
addressed
limitations
SDT
achieves
simultaneous
both
immunotherapy,
resulting
significant
anti-metastatic
TNBC.
Journal of Materials Chemistry B,
Год журнала:
2023,
Номер
11(36), С. 8586 - 8604
Опубликована: Янв. 1, 2023
Immunotherapy
is
a
new
type
of
tumor
treatment.
In
this
review,
the
main
focus
on
an
overview
research
progress
immunotherapy
in
cancer
treatment
and
combined
application
with
other
therapeutic
approaches.
Acta Pharmaceutica Sinica B,
Год журнала:
2023,
Номер
14(5), С. 2263 - 2280
Опубликована: Дек. 16, 2023
Chemotherapeutics
can
induce
immunogenic
cell
death
(ICD)
in
tumor
cells,
offering
new
possibilities
for
cancer
therapy.
However,
the
efficiency
of
immune
response
generated
is
insufficient
due
to
inhibitory
nature
microenvironment
(TME).
Here,
we
developed
a
pH/reactive
oxygen
species
(ROS)
dual-response
system
enhance
chemoimmunotherapy
melanoma.
The
productively
accumulated
tumors
by
specific
binding
phenylboronic
acid
(PBA)
sialic
acids
(SA).
nanoparticles
(NPs)
rapidly
swelled
and
released
quercetin
(QUE)
doxorubicin
(DOX)
upon
stimulation
Advanced NanoBiomed Research,
Год журнала:
2024,
Номер
4(4)
Опубликована: Янв. 26, 2024
This
review
is
aiming
to
systematically
elucidate
the
unique
role
of
nanotechnology
in
optimizing
therapeutic
modalities
for
combinatorial
cancer
immunotherapy,
which
enables
synergistic
integration
multiple
treatment
strategies.
In
particular,
has
enabled
combination
immunotherapy
with
physical
therapies,
chemotherapy,
metal
therapy,
and
nucleic
acid
therapy.
each
regimen,
nanocarriers
play
multifaceted
roles
by
achieving
targeted
codelivery
different
therapeutics
individual
modality.
offers
new
paradigms
guide
precision
medicine
treatment.
Immunotherapy
alone
unlikely
achieve
personalized
cancer,
are
needed
future.
To
overcome
technical
bottlenecks
realize
precise
regulation
tumor
microenvironment
treatment,
it
crucial
develop
novel
nanosystems
integrated
sensing,
targeting,
functionalities.
