Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
177, С. 117007 - 117007
Опубликована: Июнь 20, 2024
This
study
demonstrates
the
potential
of
gelatin
nanoparticles
as
a
nanodelivery
system
for
antagonists
nicotinic
acetylcholine
receptors
(nAChRs)
to
improve
chemotherapy
efficacy
and
reduce
off-target
effects.
Too
often,
lung
cancer
does
not
lead
satisfactory
results.
Therefore,
new
approaches
directed
at
multiple
pharmacological
targets
in
therapy
are
being
developed.
Following
activation
nAChRs
(e.g.
by
nicotine),
cells
begin
proliferate
become
more
resistant
chemotherapy-induced
apoptosis.
work
shows
that
3-alkylpyridinium
salt,
APS7,
synthetic
analog
toxin
from
marine
sponge
Haliclona
(Rhizoneira)
sarai,
acts
an
nAChR
antagonist
inhibits
pro-proliferative
anti-apoptotic
effects
nicotine
on
A549
human
adenocarcinoma
cells.
In
this
study,
gelatin-based
filled
with
APS7
(APS7-GNPs)
were
prepared
their
compared
free
APS7.
Both
APS7-GNPs
inhibited
Ca2+
influx
increased
cisplatin
nicotine-stimulated
However,
significant
benefits
observed
–
stronger
reduction
proliferation
much
higher
selectivity
cytotoxicity
towards
non-tumorigenic
epithelial
BEAS-2B
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
Nanomedicine,
Год журнала:
2025,
Номер
unknown, С. 1 - 12
Опубликована: Фев. 4, 2025
Aim
To
develop
a
new
drug
delivery
system
(DDS)
that
can
load
chemotherapy
agents
and
photosensitizer
chlorin
e6
(Ce6)
onto
the
pores
surfaces
of
mesoporous
silica
nanoparticle
(MSN)
separately.
Cells,
Год журнала:
2024,
Номер
13(11), С. 958 - 958
Опубликована: Июнь 1, 2024
Autophagy
is
a
globally
conserved
cellular
activity
that
plays
critical
role
in
maintaining
homeostasis
through
the
breakdown
and
recycling
of
constituents.
In
recent
years,
there
has
been
much
emphasis
given
to
its
complex
cancer
stem
cells
(CSCs)
cell
treatment.
This
study
examines
molecular
processes
support
autophagy
how
it
regulated
context
CSCs
Although
dual
management
CSCs,
affecting
their
removal
as
well
maintenance,
intricate
interaction
between
several
signaling
channels
control
survival
death
part
mechanism
not
elucidated.
Given
have
development,
progression,
resistance
treatment
tumors,
imperative
comprehend
biological
activities.
are
important
for
biology
because
they
also
show
tissue
regeneration
model
helps
with
organoid
regeneration.
other
words,
manipulation
viable
therapeutic
approach
therapy.
Both
synthetic
natural
substances
target
pathways
demonstrated
promise
improving
cell-based
therapies
eliminating
CSCs.
Nevertheless,
difficulties
associated
limitations
CSC
regulation,
including
mechanisms
off-target
effects.
Thus,
regulation
offers
versatile
strategy
focusing
on
enhancing
results
Therefore,
understanding
interactions
would
be
essential
creating
treatments
work
both
regenerative
medicine
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2633 - 2633
Опубликована: Март 14, 2025
Cancer
is
one
of
the
main
causes
death
worldwide.
Chemotherapy,
radiotherapy
and
surgery
are
currently
treatments
choice
for
cancer.
However,
conventional
therapies
have
their
limitations,
such
as
non-specificity,
tumor
recurrence
toxicity
to
target
cells.
Recently,
nanomaterials
been
considered
therapeutic
agents
against
This
mainly
due
unique
optical
properties,
biocompatibility,
large
surface
area
nanoscale
size.
These
properties
crucial
they
can
affect
biocompatibility
uptake
by
cell,
reducing
efficacy.
because
nanoparticles
be
functionalized
with
biomolecules,
become
more
biocompatible,
which
improves
uptake,
specifically
targeted
cancer
cells,
anticancer
activity.
In
this
review,
we
summarize
some
recent
studies
in
aim
increasing
efficacy
treatment.
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Апрель 15, 2025
Cancer
immunotherapy
aims
to
harness
the
body's
own
immune
system
for
effective
and
long-lasting
elimination
of
malignant
neoplastic
tissues.
Owing
advance
in
understanding
cancer
pathology
immunology,
many
novel
strategies
enhancing
immunological
responses
against
various
cancers
have
been
successfully
developed,
some
translated
into
excellent
clinical
outcomes.
As
one
promising
strategy
next
generation
immunotherapies,
activating
multi-cellular
network
(MCN)
within
tumor
microenvironment
(TME)
deploy
multiple
mechanisms
action
(MOAs)
has
attracted
significant
attention.
To
achieve
this
effectively
safely,
delivering
or
pleiotropic
therapeutic
cargoes
targeted
sites
cancerous
tissues,
cells,
intracellular
organelles
is
critical,
which
numerous
nanocarriers
developed
leveraged.
In
review,
we
first
introduce
payloads
categorized
according
their
predicted
functions
physicochemical
structures
forms.
Then,
nanocarriers,
along
with
unique
characteristics,
properties,
advantages,
limitations,
are
introduced
notable
recent
applications
immunotherapy.
Following
discussions
on
targeting
strategies,
a
summary
each
nanocarrier
matching
suitable
provided
comprehensive
background
information
designing
regimens.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 7273 - 7305
Опубликована: Июль 1, 2024
Abstract:
Dried
toad
skin
(TS)
and
venom
(TV)
are
the
dried
of
Bufo
bufo
gargarizans
Cantor
melanostictus
Schneider
,
which
remove
internal
organs
white
secretions
retroauricular
glands.
Since
2005,
cinobufacini
preparations
have
been
approved
by
State
Food
Drug
Administration
for
use
as
adjuvant
therapies
in
treatment
various
advanced
cancers.
Meanwhile,
bufalenolides
has
identified
main
component
TS/TV,
exhibiting
antitumor
activity,
inducing
apoptosis
cancer
cells
inhibiting
cell
proliferation
or
metastasis
through
a
variety
signaling
pathways.
However,
clinical
agents
frequently
face
limitations
such
inherent
toxicity
at
high
concentrations
insufficient
tumor
targeting.
Additionally,
development
utilization
these
active
ingredients
hindered
poor
water
solubility,
low
bioavailability,
rapid
clearance
from
bloodstream.
To
address
challenges,
design
targeted
drug
delivery
system
(TDDS)
aims
to
enhance
improve
targeting
within
body,
increase
efficacy,
reduce
adverse
reactions.
This
article
reviews
TDDS
their
components,
including
passive,
active,
stimuli-responsive
TDDS,
provide
reference
advancing
use.
Keywords:
skin,
venom,
system,
passive
targeted,
