Coordination Chemistry Reviews, Год журнала: 2024, Номер 520, С. 216124 - 216124
Опубликована: Авг. 12, 2024
Язык: Английский
Процитировано
22
Separation and Purification Technology, Год журнала: 2025, Номер unknown, С. 132203 - 132203
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
2
Journal of Alloys and Compounds, Год журнала: 2025, Номер unknown, С. 178578 - 178578
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Molecular Pharmaceutics, Год журнала: 2025, Номер unknown
Опубликована: Фев. 6, 2025
The first-in-class oncolytic peptide LTX-315 has exhibited positive anticancer responses in multiple phase I/II clinical trials. Nevertheless, the linear suffers from poor proteolytic stability and undesired toxicity, especially hemolysis, which may limit its widespread applications. Except for direct structural modifications, drug delivery systems (DDSs) are expected to protect degradation shield hemolytic properties. Therefore, zeolitic imidazolate framework (ZIF-8)-based nanoparticles (NPs) were constructed with a high encapsulation rate of 59.9%, utilizing biomineralized "one-pot method" an aqueous system. release LTX-315, vitro potency, serum stability, durability, antimigration activity, hemolysis effect, subcellular localization, membrane disruption/permeation effects LTX-315@ZIF-8 NPs investigated. potent cytotoxicity against cancer cells. experiment time-inhibition curve assay indicated that ZIF-8 could effectively improve prolong duration action, enhance cytostatic potency. Especially, not only attenuated toxicity but also achieved pH-responsive LTX-315. mechanism investigation possessed membranolytic activity reduced mitochondrial potential trigger cell death. Collectively, this paper established robust strategy reduce properties provided reliable reference future peptides.
Язык: Английский
Процитировано
1
Chemical Engineering Journal, Год журнала: 2024, Номер 498, С. 155122 - 155122
Опубликована: Авг. 29, 2024
Язык: Английский
Процитировано
9
Journal of Materials Chemistry B, Год журнала: 2025, Номер 13(10), С. 3270 - 3291
Опубликована: Янв. 1, 2025
Antibiotic resistance presents an alarming threat to global health, with bacterial infections now ranking among the leading causes of mortality. To address this escalating challenge, strategies such as antibiotic stewardship, development antimicrobial therapies, and exploration alternative treatment modalities are imperative. Metal-organic frameworks (MOFs), acclaimed for their outstanding biocompatibility in vivo biodegradability, promising avenues synthesis novel agents under mild conditions. Among these, zeolitic imidazolate (ZIFs), a remarkable subclass MOFs, have emerged potent antibacterial materials; efficacy which stems from porous structure, metal ion content, tunable functionalized groups. This could be further enhanced by incorporating or encapsulating ions, Cu, Fe, Ti, Ag, others. perspective aims underscore potential ZIFs underlying mechanisms including release generation reactive oxygen species (ROS), disruption cell walls, synergistic interactions other agents. These attributes position candidates advanced applications combating infections. Furthermore, we propose approach synthesizing derivatives, demonstrating exceptional against Escherichia coli Staphylococcus aureus. By highlighting benefits derivatives agents, emphasizes critical challenge resistance.
Язык: Английский
Процитировано
1
Microporous and Mesoporous Materials, Год журнала: 2025, Номер unknown, С. 113588 - 113588
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
1
BMC Chemistry, Год журнала: 2025, Номер 19(1)
Опубликована: Март 27, 2025
According to the narrow therapeutic range and multiple adverse effects of cyclosporine need for its drug monitoring (TDM), in this study, an efficient zeolitic imidazolate framework-8 metal-organic framework (ZIF-8 MOF) based nanoprobe was designed simple, rapid high sensitive quantification plasma samples. After successful synthesis ZIF-8 MOF, under optimum condition, fluorescence emission measured at excitation wavelength 370 nm 417 nm, enhanced with increasing concentration, due specific interactions between nanoprobe, including hydrogen bonding hydrophobic effects. The showed a linear correlation analytical response concentration 0.01–1.0 µg mL− 1, detection limit 0.003 1. Acceptable precision achieved, evidenced by intra-day inter-day relative standard deviations 0.4% 0.5%, respectively. Recovery 97.1% 102.1% samples indicated method's reliability practical applications.
Язык: Английский
Процитировано
1
Nanoscale, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Metal-organic framework (MOF)-derived carbons, known for their highly tunable structures, have attracted considerable attention electrochemical applications. Efficient ion and electron transport, along with low electrode resistance, is critical enhancing performance in these areas. To optimize MOF-derived we synthesize Zn-based zeolitic imidazolate (ZIF-8) nanocrystals controlled sizes a narrow size distribution, resulting nanoporous polyhedral carbon structures. The sample then subjected to carbonization yield ZIF-8-derived (ZIF-8-C) doped heteroatoms, subsequently, evaluations of supercapacitors are conducted assess transport properties. Larger particles exhibit greater capacitance loss at high scan rates or current densities, likely due underutilization pores diffusion. Uniform particle facilitate ordered packing, improving pathways compared electrodes non-uniform yielding higher despite similar specific surface Notably, the prepared smallest most uniformly sized ZIF-8-C-m1 exhibits 206.4 F g-1 1 A g-1, excellent rate capability stability, retaining 99.7% its after 10 000 cycles g-1. In two-electrode system, it achieves an energy density up 19.4 W h kg-1 power 350 kg-1. results present here offer valuable insights into utilization carbons across diverse
Язык: Английский
Процитировано
1
Inorganic Chemistry Communications, Год журнала: 2024, Номер unknown, С. 113333 - 113333
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
4