Advances in Microfluidics-Enabled Dimensional Design of Micro-/Nanomaterials for Biomedical Applications: A Review
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 19, 2025
Biomedical
materials
are
of
great
significance
for
preventing
and
treating
major
diseases
protecting
human
health.
At
present,
more
stringent
requirements
have
been
put
forward
the
preparation
methods
dimension
control
biomedical
based
on
urgent
demand
high-performance
materials,
especially
existence
various
physiological
size
thresholds
in
vitro/in
vivo.
Microfluidic
platforms
break
limitations
traditional
micro-/nanomaterial
synthesis,
which
provide
a
miniaturized
highly
controlled
environment
size-dependent
biomaterials.
In
this
review,
basic
conceptions
technical
characteristics
microfluidics
first
described.
Then
syntheses
with
different
dimensions
(0D,
1D,
2D,
3D)
driven
by
systematically
summarized.
Meanwhile,
applications
microfluidics-driven
including
diagnosis,
anti-inflammatory,
drug
delivery,
antibacterial,
disease
therapy,
discussed.
Furthermore,
challenges
developments
research
field
further
proposed.
This
work
is
expected
to
facilitate
convergence
between
bioscience
engineering
communities
continue
contribute
emerging
field.
Язык: Английский
Unveiling the Heart’s Hidden Enemy: Dynamic Insights into Polystyrene Nanoplastic-Induced Cardiotoxicity Based on Cardiac Organoid-on-a-Chip
ACS Nano,
Год журнала:
2024,
Номер
18(45), С. 31569 - 31585
Опубликована: Ноя. 1, 2024
Exposure
to
micro-
and
nanoplastics
(MNPs)
has
been
implicated
in
potential
cardiotoxicity.
However,
vitro
models
based
on
cardiomyocyte
cell
lines
lack
crucial
cardiac
characteristics,
while
interspecies
differences
animal
compromise
the
reliability
of
conclusions.
In
addition,
current
research
predominantly
focused
single-time
point
exposures
MNPs,
neglecting
comparative
analyses
injury
across
early
late
stages.
Moreover,
there
remains
a
large
gap
understanding
susceptibility
MNPs
under
pathological
conditions.
To
address
these
limitations,
this
study
integrated
organoids
(COs)
organ-on-a-chip
(OoC)
technology
develop
organoid-on-a-chip
(COoC),
which
was
validated
for
cardiotoxicity
evaluation
through
multiple
dimensions.
Based
COoC,
we
conducted
dynamic
observation
damage
caused
by
short-
long-term
exposure
polystyrene
(PS-NPs).
Oxidative
stress,
inflammation,
disruption
calcium
ion
homeostasis,
mitochondrial
dysfunction
were
confirmed
as
mechanisms
PS-NP-induced
events
stages,
fibrosis
emerged
prominent
feature
Notably,
low-dose
exacerbated
myocardial
infarction
symptoms
states,
despite
no
significant
shown
healthy
models.
conclusion,
findings
further
deepened
our
cardiotoxic
effects
introduced
promising
platform
assessing
Язык: Английский
Material‐Mediated Immunotherapy to Regulate Bone Aging and Promote Bone Repair
Small,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 21, 2025
Abstract
As
the
global
population
ages,
an
increasing
number
of
elderly
people
are
experiencing
weakened
bone
regenerative
capabilities,
resulting
in
slower
repair
processes
and
associated
risks
various
complications.
This
review
outlines
research
progress
on
biomaterials
that
promote
through
immunotherapy.
examines
how
manufacturing
technologies
such
as
3D
printing,
electrospinning,
microfluidic
technology
contribute
to
enhancing
therapeutic
effects
these
biomaterials.
Following
this,
it
provides
detailed
introductions
anti‐osteoporosis
drug
delivery
systems,
injectable
hydrogels,
nanoparticles,
engineered
exosomes,
well
tissue
engineering
materials
coatings
used
immunomodulation.
Moreover,
critically
analyzes
current
limitations
biomaterial‐mediated
immunotherapy
explores
future
directions
for
material‐mediated
aims
inspire
new
approaches
broaden
perspectives
addressing
challenges
aging
by
exploring
innovative
strategies.
Язык: Английский
Localized Growth Factor Delivery from Microparticles Modulates Osteogenic and Chondrogenic Gene Expression in a Growth Factor-Dependent Manner in an ex vivo Chick Embryonic Bone Model
Опубликована: Янв. 1, 2025
Язык: Английский
Effective and new technologies in kidney tissue engineering
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Окт. 16, 2024
Kidney
disease
encompasses
a
wide
spectrum
of
conditions,
ranging
from
simple
infections
to
chronic
kidney
disease.
When
the
kidneys
are
unable
filter
blood
and
remove
waste
products,
these
abnormalities
can
lead
failure.
In
severe
cases
failure,
transplantation
is
considered
only
definitive
treatment.
Worldwide,
World
Health
Organization
(WHO)
repeatedly
emphasizes
importance
organ
donation
increasing
rates.
Many
countries
implement
national
programs
promote
culture
improve
patient
access
transplantation.
The
extent
which
this
procedure
performed
varies
across
influenced
by
several
factors,
including
volume
donation,
medical
infrastructure,
technology
health
policies.
However,
transplant
comes
with
challenges
problems
that
impact
its
success.
tissue
engineering
new
approach
shows
promise
for
repairing
replacing
damaged
tissue.
This
article
reviews
recent
advances
in
engineering,
focusing
on
engineered
structures
such
as
hydrogels,
electrospinning,
3D
bioprinting,
microfluidic
systems.
By
mimicking
extracellular
environment
kidney,
provide
suitable
conditions
growth
development
cells.
role
formation
vessels,
mimicry
functions
field
were
also
discussed.
results
study
show
has
high
potential
treating
diseases
reducing
need
achieve
clinical
application
technology,
further
research
required
biocompatibility,
vascularization
long-term
performance
tissues.
Язык: Английский
Combating Cellular Aging: Frontiers in Biomaterials and Therapies
ACS Materials Letters,
Год журнала:
2024,
Номер
7(1), С. 1 - 23
Опубликована: Ноя. 21, 2024
With
the
continuous
increase
in
average
life
expectancy,
population
aging
has
become
a
significant
health
issue
21st
century.
The
rising
prevalence
of
age-related
diseases
brought
tremendous
pressure
on
social
medical
systems
and
economy.
Against
this
backdrop,
research
anticellular
hot
spot
field
biomedicine,
biomaterials
are
showing
new
trends
potential
area.
Compared
to
drugs
other
traditional
anti-aging
strategies,
can
be
personalized
target
characteristics
different
tissues,
serving
as
drug
delivery
carriers
enhance
targeting,
directly
influence
cellular
process
by
modulating
microenvironment.
Furthermore,
offer
innovative
approaches
diagnosing
building
sophisticated
models,
which
our
understanding
biology
behind
speed
up
advancement
novel
treatments.
This
review
synthesizes
latest
advancements
biomaterial
for
combating
aging,
exploring
future
prospects
challenges.
Язык: Английский