Recent advances in hyaluronic acid-based hydrogels for diabetic wound healing

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 304, С. 140797 - 140797

Опубликована: Фев. 7, 2025

Язык: Английский

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A nano drug delivery system loading drugs and chlorin e6 separately to achieve photodynamic-chemo combination therapy

Nanomedicine, Год журнала: 2025, Номер unknown, С. 1 - 12

Опубликована: Фев. 4, 2025

Aim To develop a new drug delivery system (DDS) that can load chemotherapy agents and photosensitizer chlorin e6 (Ce6) onto the pores surfaces of mesoporous silica nanoparticle (MSN) separately.

Язык: Английский

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Recent Advances in Glutathione Depletion-Enhanced Porphyrin-Based nMOFs for Photodynamic Therapy

Pharmaceutics, Год журнала: 2025, Номер 17(2), С. 244 - 244

Опубликована: Фев. 12, 2025

Photodynamic therapy has established itself as a clinical treatment for certain superficial cancers by converting oxygen into cytotoxic singlet to eradicate cancer cells. Porphyrin-based nanoscale metal-organic frameworks have emerged promising photosensitive platforms due their ability prevent the hydrophobic aggregation quenching of porphyrin molecules and enhance accumulation at tumor site, thereby becoming focal point in photodynamic materials research. However, elevated levels glutathione other reductive substances within cells can alleviate oxidative stress induced from process, thus protecting intracellular biomolecular structures damage. Consequently, it is crucial design functionalized nanoplatforms that integrate depletion with porphyrin-based significantly boost efficacy. Moreover, excess disrupt structure frameworks, which not only increases capacity generate upon light exposure but also aids recovery fluorescence imaging capabilities. Additionally, this specificity minimizes photosensitizing harm normal tissues. This review compiles recent advancements developing enhanced phototherapy through depletion. It aims promote further application provide valuable insights preclinical applications. By highlighting strategies improve therapeutic outcomes while maintaining safety profiles, summary seeks advance development more effective targeted treatments.

Язык: Английский

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Bio-inspired, programmable biomacromolecules based nanostructures driven cancer therapy

Biomaterials Advances, Год журнала: 2025, Номер 171, С. 214235 - 214235

Опубликована: Фев. 15, 2025

Язык: Английский

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Multiple Recessions Coverage Using the Modified Tunnel Technique and Connective Tissue Graft with or Without Cross-Linked Hyaluronic Acid: 2-Year Outcomes of RCT

Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(3), С. 87 - 87

Опубликована: Март 4, 2025

There is continuing interest in using biologics root coverage procedures. The aim of the present study was to explore 2-year outcomes following multiple gingival recessions (GRs) application cross-linked hyaluronic acid (HA) combination with modified coronally advanced tunnel (MCAT) together subepithelial connective tissue graft (SCTG). Adopting a split-mouth design, 266 GRs were randomly allocated either test (MCAT + SCTG HA) or control group SCTG). main outcome variable stability obtained mean from 6 months 24 months. Twenty-four patients evaluated at follow-up. Comparisons between and sides same time points t-test for independent variables. changes compared by one-way analysis variance Tukey post hoc separately groups. protocol registered ClinicalTrials.gov (NCT05045586). At 2 years, around ninety percent showed complete (87.02% 91.90% group). Mean did not differ two sides, 81.37 ± 37.17% (test) 84.63 35.33% (control), respectively. Significant improvements reduction recession height, clinical attachment level gain, thickness increase, esthetic score found both groups after but no statistically significant difference observed adjunctive HA significantly improved soft texture (STT, 0.94 0.23 vs. 0.71 0.46 Treatment MCAT without yielded marked comparable outcomes, which could be maintained over period relevance demonstrated STT may minimal.

Язык: Английский

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The Role of Inorganic Nanomaterials in Overcoming Challenges in Colorectal Cancer Diagnosis and Therapy

Pharmaceutics, Год журнала: 2025, Номер 17(4), С. 409 - 409

Опубликована: Март 25, 2025

Colorectal cancer poses a significant threat to human health due its high aggressiveness and poor prognosis. Key factors impacting patient outcomes include post-surgical recurrence, chemotherapeutic drug resistance, insensitivity immunotherapy. Consequently, early diagnosis the development of effective targeted therapies are essential for improving prevention treatment strategies. Inorganic nanomaterials have gained prominence in colorectal owing their unique size, advantageous properties, modifiability. Various types inorganic nanomaterials—such as metal-based, metal oxide, quantum dots, magnetic nanoparticles, carbon-based, rare-earth nanomaterials—have demonstrated potential enhancing multimodal imaging, delivery, synergistic therapies. These advancements underscore critical role therapeutic outcomes. This review highlights properties nanomaterials, summarizes recent applications progress treatment, discusses challenges translating these materials into clinical use. It aims provide valuable insights future research application management.

Язык: Английский

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A mitochondrial-targeted nanomedicine based on hollow mesoporous silica nanoparticles for enhanced colorectal cancer therapy

Colloids and Interface Science Communications, Год журнала: 2025, Номер 66, С. 100833 - 100833

Опубликована: Март 26, 2025

Язык: Английский

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Porphyrin-based covalent organic framework with NIR absorption: Preparation, hyaluronic acid modification, and cascading a hypoxia-sensitive drug for synergistic therapy of cancer phototherapy/chemotherapy

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142645 - 142645

Опубликована: Март 1, 2025

Язык: Английский

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Engineered Exosomes Loaded in Intrinsic Immunomodulatory Hydrogels with Promoting Angiogenesis for Programmed Therapy of Diabetic Wounds

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 6, 2025

Inducing rapid angiogenesis by delivering specific biological cues is critical for diabetic wound healing. Nevertheless, the hindered inflammatory microenvironment, and immune cells fail to orchestrate responses Herein, vascular endothelial growth factor (VEGF) plasmids-loaded macrophage exosomes (Exos) were fabricated enfolded in injectable self-healing hydrogels programmed therapy of wounds through sequentially intrinsically modulating microenvironment promoting angiogenesis. The hydrogels, formed via dynamical Schiff base reactions using modified polysaccharides, regulate broad-spectrum antioxidant activity phenotype regulation, restoring tissue redox homeostasis. Furthermore, can stabilize release engineered exosomes. By integration generation VEGF Exos, secretion M2 macrophages, enhanced binding receptor 2 high affinity sulfated chitosan, intrinsic immunomodulatory effectively promote accelerate healing process.

Язык: Английский

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A pillar[5]arene-based hyaluronic acid-decorated amorphous bimetallic metal-organic framework for multimodal synergistic cancer therapy

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142994 - 142994

Опубликована: Апрель 1, 2025

Язык: Английский

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