Liquid Chromatography‐Tandem Mass Spectrometry Analysis and Pharmacokinetics of Doxorubicin and Its Prodrug in Rats After Administration of Nanoparticles DOI Open Access

Chenxia Bai,

Xiaolong Xu, Jiaming Zhang

и другие.

Separation Science Plus, Год журнала: 2024, Номер 8(1)

Опубликована: Дек. 27, 2024

ABSTRACT To further improve the dilemma facing clinical application of doxorubicin (DOX), we designed a cathepsin B sensitive DOX prodrug albumin nanoparticle (NP). evaluate pharmacokinetics NPs (C16‐GFLG‐PAB‐DOX NPs), developed and validated liquid chromatography‐tandem mass spectrometry method for same time analysis its fatty acid (C16‐GFLG‐PAB‐DOX) in rat plasma. The uses precipitated protein to extract analytes from on selectivity, linearity ( r ≥ 0.992), precision (relative standard deviation: 3.5%–9.5%), accuracy error: −2.9% 3.5%), extraction recovery (80.2% 90.4%), matrix effect (87.8% 96.6%), stability different conditions were satisfied. Therefore, pharmacokinetic behavior C16‐GFLG‐PAB‐DOX rats was investigated using this analytical approach. outcome study illustrated that are promising alleviate problems associated with applications.

Язык: Английский

Synergistic effect of hyperoside and amentoflavone found in cashew leaf crude extract and potassium sorbate on inhibition of food spoilage bacteria DOI Creative Commons
Pitima Sinlapapanya, Suriya Palamae, Jirayu Buatong

и другие.

Journal of Agriculture and Food Research, Год журнала: 2025, Номер unknown, С. 101886 - 101886

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Vortex‐Assisted Magnetic Solid‐Phase Extraction of Heavy Metals in Water and Food Samples Using Iron Oxide Nanoparticle‐Impregnated Carboxymethyl‐β‐Cyclodextrin DOI

Mansoor Ahmad,

A. Badshah, Hongji Li

и другие.

Journal of Separation Science, Год журнала: 2024, Номер 47(20)

Опубликована: Окт. 1, 2024

ABSTRACT The excessive accumulation of heavy metals has adverse effects on the human body. Here, magnetic iron oxide‐impregnated carboxymethyl‐β‐cyclodextrin was synthesized. synthesized material employed as a solid‐phase extracting adsorbent for specific like lead (Pb), nickel (Ni), copper (Cu), and cobalt (Co). Characterization performed by X‐ray diffraction, energy dispersive spectroscopy, scanning electron microscopy, Brunauer–Emmett–Teller, Fourier‐transform infrared spectroscopy. analytical merits, detection limits (Pb: 1.38 ng/mL, Ni: 0.5 Co: 0.14 Cu: 0.55 ng/mL) quantification 4.14 1.62 1.85 1.82 were calculated. Similarly, preconcentration enhancement factors (15) relative standard deviation 3.5, 0.92, 2.7, 1.5) also interfering study shows that method is highly selective. For validation, it applied to certified reference materials such Institute Nuclear Chemistry Technology ornamental Basma tobacco leaves trace metal double addition 63.4 environmental water with good percent recovery values (92%–99%). Real food samples used satisfactory (90%–99%) results.

Язык: Английский

Процитировано

0

Liquid Chromatography‐Tandem Mass Spectrometry Analysis and Pharmacokinetics of Doxorubicin and Its Prodrug in Rats After Administration of Nanoparticles DOI Open Access

Chenxia Bai,

Xiaolong Xu, Jiaming Zhang

и другие.

Separation Science Plus, Год журнала: 2024, Номер 8(1)

Опубликована: Дек. 27, 2024

ABSTRACT To further improve the dilemma facing clinical application of doxorubicin (DOX), we designed a cathepsin B sensitive DOX prodrug albumin nanoparticle (NP). evaluate pharmacokinetics NPs (C16‐GFLG‐PAB‐DOX NPs), developed and validated liquid chromatography‐tandem mass spectrometry method for same time analysis its fatty acid (C16‐GFLG‐PAB‐DOX) in rat plasma. The uses precipitated protein to extract analytes from on selectivity, linearity ( r ≥ 0.992), precision (relative standard deviation: 3.5%–9.5%), accuracy error: −2.9% 3.5%), extraction recovery (80.2% 90.4%), matrix effect (87.8% 96.6%), stability different conditions were satisfied. Therefore, pharmacokinetic behavior C16‐GFLG‐PAB‐DOX rats was investigated using this analytical approach. outcome study illustrated that are promising alleviate problems associated with applications.

Язык: Английский

Процитировано

0