Exploring cellular dynamics: Engineered fluorescent carbon dots for organelle staining and cellular response analysis

Coordination Chemistry Reviews, Год журнала: 2025, Номер 534, С. 216552 - 216552

Опубликована: Март 3, 2025

Язык: Английский

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Carbon Dots Derived from Tea Polyphenols as Photosensitizers for Photodynamic Therapy

Molecules, Год журнала: 2022, Номер 27(23), С. 8627 - 8627

Опубликована: Дек. 6, 2022

Photodynamic therapy (PDT) has become an emerging cancer treatment method. Choosing the photosensitizer (PS) compounds is one of essential factors that can influence PDT effect and action. Carbon dots (CDs) have shown great potential as photosensitizers in cancers due to their excellent biocompatibility high generation reactive oxygen species (ROS). Here, we used tea polyphenol raw material for synthesized carbon (T-CDs) show dual emission bands red blue fluorescence efficiently generate hydroxyl radicals (OH) under mildly visible irradiation with a LED light (400-500 nm, 15 mW cm-2). The extremely low cytotoxicity T-CDs without were tested using MTT hemolytic assay. Further, been by vivo experiments, mouse breast cell line (4T1) subcutaneously injected back buttock model, effectively inhibit tumor proliferation solid tumors effect. In addition, pathological sections mice tissues after further showed had no apparent impact on major organs did not produce any side lesions. This work demonstrates as-synthesized be PS treatment.

Язык: Английский

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Nucleus-targeting pH-Responsive carbon dots for fast nucleus pH detection

Talanta, Год журнала: 2022, Номер 252, С. 123855 - 123855

Опубликована: Авг. 19, 2022

Язык: Английский

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High fluorescent nitrogen − doped carbon dots derived from Sanghuangporus lonicericola for detecting tetracyclines in aquaculture water and rat serum samples

Microchemical Journal, Год журнала: 2023, Номер 189, С. 108517 - 108517

Опубликована: Фев. 13, 2023

Язык: Английский

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Multifunctional carbon dots for glutathione detection and Golgi imaging

Talanta, Год журнала: 2023, Номер 259, С. 124520 - 124520

Опубликована: Апрель 6, 2023

Язык: Английский

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Long-term antibacterial activity of guanidinium carbon dots without detectable resistance for the effective treatment of pneumonia caused by Gram-negative bacteria

Carbon, Год журнала: 2023, Номер 213, С. 118229 - 118229

Опубликована: Июнь 20, 2023

Язык: Английский

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Advances in the design and use of carbon dots for analytical and biomedical applications

Nanotechnology, Год журнала: 2023, Номер 35(1), С. 012001 - 012001

Опубликована: Сен. 27, 2023

Abstract Carbon dots (CDs) have garnered significant interest for their potential use in multiple applications due to size, fluorescent properties, high photostability, low toxicity and biocompatibility. CDs can be tailored specific needs, as they synthesized with diverse precursors techniques functionalization. Since the of are rapidly expanding, this review highlights recent developments burgeoning field. Specifically, we describe advances CD synthesis that include pH temperature sensing, biochemical analysis, bioimaging. We also discuss various challenges practical solutions will drive CD-based research forward. Challenges lack standardized purification methods CDs, clarity regarding mechanism action, procedural flaws applications. In conclusion, provide recommendations collaboration among disciplines bridge existing knowledge gaps address key required fully commercialized.

Язык: Английский

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Recent advances in red-emissive carbon dots and their biomedical applications

Materials Chemistry Frontiers, Год журнала: 2023, Номер 8(4), С. 930 - 955

Опубликована: Дек. 7, 2023

This review mainly summarizes the research advances in synthetic strategies, optical properties, and biomedical applications of red-emissive carbon dots recent years.

Язык: Английский

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Ultrabright Green-Emissive Nanodots for Precise Biological Visualization

Nano Letters, Год журнала: 2024, Номер 24(7), С. 2264 - 2272

Опубликована: Фев. 7, 2024

Developing general methods to fabricate water-dispersible and biocompatible fluorescent probes will promote different biological visualization applications. Herein, we report a metal-facilitated method ultrabright green-emissive nanodots via the one-step solvothermal treatment of rose bengal, ethanol, various metal ions. These metal-doped show good water dispersity, ultrahigh photoluminescence quantum yields (PLQYs) (e.g., PLQY Fe-doped (FeNDs) was ∼97%), low phototoxicity. Owing coordination effect ions, FeNDs realize glutathione detection with outstanding properties. Benefiting from high endoplasmic reticulum (ER) affinity chloride group, can act as an ER tracker long imaging capacity (FeNDs: >24 h; commercial tracker: ∼1 h) superb photostability achieve tissue in living

Язык: Английский

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Carbon‐based nanodots for biomedical applications and clinical transformation prospects

BMEMat, Год журнала: 2024, Номер 2(3)

Опубликована: Май 11, 2024

Abstract Carbon dots (CDs), emerging as a promising class of nanomaterials, have garnered significant interest in the field biomedicine due to their unique physicochemical properties. This review provides comprehensive overview recent advancements biomedical applications CDs, emphasizing potential for revolutionizing diagnostics, therapy, and bio‐imaging. We discuss synthesis functionalization which are pivotal tailoring properties specific applications. The CDs bioimaging include fluorescence imaging, magnetic resonance photoacoustic etc. Additionally, this delves into benefits treatment diseases including cancer, inflammation Alzheimer's, Finally, we look forward future biomedicine, necessity interdisciplinary collaboration overcome current obstacles facilitate clinical translation CDs‐based technologies. aims provide summary perspectives on latest developments hoping inspire further research rapidly advancing field.

Язык: Английский

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