Research Progress on Antibacterial Applications of Bioactive Materials in Wound Infections: Design, Challenges, and Prospects

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 21, 2025

Bacterial wound infections pose a significant threat to global health, exacerbated by the increase in multidrug-resistant bacteria (MDRB) and formation of elastic biofilms. This review explores transformative potential bioactive materials addressing these challenges, focusing on their design, mechanisms action, therapeutic effects. In vivo, are designed respond unique bacterial microenvironment (BME), utilizing enzyme activity, controlled gas release, surface functionalization, immune regulation combat infections. vitro, this provides comprehensive overview latest advances rational design materials, emphasizing synergistic integration structural modifications (such as size morphology) with external physical stimuli light, sound, electricity, magnetism, force) enhance antibacterial performance. Finally, outstanding challenges prospects rapidly evolving field discussed.

Язык: Английский

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Advanced healing potential of simple natural hydrogel loaded with sildenafil in combating infectious wounds

International Journal of Pharmaceutics X, Год журнала: 2025, Номер unknown, С. 100328 - 100328

Опубликована: Март 1, 2025

Infected wounds are common clinical injuries that often complicated by inflammation and oxidative stress due to bacterial invasion. These typically suffer from impaired vascularization, which delays healing increases the risk of complications such as sepsis chronic wounds. Therefore, developing an effective treatment for infected is highly necessary. Egg white can promote cell regeneration repair, while chitosan in resisting Sildenafil believed have potential angiogenesis. Based on these properties, we prepared a new type hydrogel using egg framework, loaded with sildenafil (CEHS). The combines benefits its components, exhibiting good biocompatibility promoting proliferation migration NIH 3T3 (3T3) cells human umbilical vein endothelial (HUVEC), well angiogenesis HUVEC. It also exhibits significant antioxidant, anti-inflammatory, antibacterial properties against Escherichia coli (E. coli) Staphylococcus aureus (S. aureus). Additionally, mouse model wounds, CEHS effectively promoted wound through excellent antioxidant anti-inflammatory activity, pro-angiogenic effects. In summary, this simple-to-prepare, multifunctional natural shows great promise

Язык: Английский

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Advancements in Skin Tissue Regeneration: Unveiling Emerging Treatment Strategies, Regulatory Perspectives, and Future Directions for Enhanced Healing

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106872 - 106872

Опубликована: Апрель 1, 2025

Язык: Английский

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Magnetothermal and Ultrasound-Activated Nanoplatform for the Inhalable Therapy of Bacterial Lung Infections

Acta Biomaterialia, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Structurally Engineered SO₂–Releasing Polymeric Nanoassembly for Broad-Spectrum Antibacterial Activity

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Апрель 24, 2025

Cationic antimicrobial agents are widely recognized for combating microbial infections through their membrane-disruptive properties. Recently, sulfur dioxide (SO2) gas therapy has emerged as a promising alternative treating diseases, including bacterial infections. However, current systems often target only specific strains. Herein, we present amphiphilic alternating copolymers, DAPx (x = 1, 2, 3), incorporating cationic residues and thiol-responsive SO2-releasing moieties. In aqueous environments, copolymers self-assemble into micellar nanoassemblies (DAPxNp), exposing hydrophilic outward encapsulating hydrophobic moieties within the core to enable controlled sustained release of SO2 in presence glutathione (GSH). vitro studies reveal excellent biocompatibility DAP2 Np with broad-spectrum antibacterial activity against both Gram-positive (Bacillus subtilis, Staphylococcus aureus) Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria. Mechanistic investigations confirm eradication via membrane disruption reactive oxygen species generation. This study underscores remarkable efficacy polymers resisting

Язык: Английский

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Hydrogen gas therapy: A promising approach for sepsis management post-burn injury by modulating inflammation, oxidative stress, and wound healing

CytoJournal, Год журнала: 2025, Номер 22, С. 46 - 46

Опубликована: Апрель 25, 2025

Objective Burns refers to a severe form of trauma that often leads localized and systemic inflammatory responses, oxidative stress, immune dysfunction. Patients with burns are highly susceptible the development postburn sepsis, condition influenced by multiple factors, such as bacterial infection burn wound, alterations in status, excessive release mediators. This study aimed investigate mechanisms which hydrogen gas treatment exerts its effects on focus influence wound healing. Material Methods work employed vitro assays Sprague–Dawley (SD) rat skin fibroblasts (RSFs) assess serum cell proliferation through methylthiazolyldiphenyltetrazolium bromide apoptosis flow cytometry Annexin V-fluorescein isothiocyanate/propidium iodide staining. In addition, an enzyme-linked immunosorbent assay was performed quantify cytokines stress markers treated serum. Western blotting (WB) analysis conducted signaling pathway modulation. The sepsis models SD rats were segregated into three experimental groups: healthy normal control group, + (2%) group. Wound healing monitored, contraction rates recorded histological assessments using hematoxylin eosin Masson’s trichrome staining evaluate tissue repair collagen deposition. Results showed reduced fibroblast increased ( P < 0.01), mitigated rescuing viability reducing 0.01). Enzyme-linked revealed serum-induced increases levels markers, decreases antioxidant enzymes reversed 0.05). WB suggested gas’s anti-inflammatory proliferative modulating pathways vivo , considerably improved healing, accelerated enhanced Plasma analyses indicated local from gas. Conclusion Hydrogen demonstrates potential therapeutic efficacy management promoting These findings provide scientific evidence supporting adjunctive strategy for sepsis.

Язык: Английский

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Carbon Monoxide-Enhanced antibacterial Therapy: Inhibiting bacterial Self-Perception mechanisms

Journal of Colloid and Interface Science, Год журнала: 2025, Номер 694, С. 137724 - 137724

Опубликована: Апрель 28, 2025

Язык: Английский

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Integrative gas-based therapeutics for cancer treatment: Recent advances and multi-therapy innovations

Coordination Chemistry Reviews, Год журнала: 2025, Номер 539, С. 216746 - 216746

Опубликована: Май 2, 2025

Язык: Английский

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Development of an Asymmetric Alginate Hydrogel Loaded with S-Nitrosoglutathione and Its Application in Chronic Wound Healing

Gels, Год журнала: 2025, Номер 11(5), С. 354 - 354

Опубликована: Май 12, 2025

Nitric oxide (NO) is an endogenous signaling molecule that plays a critical role in wound healing. However, the gaseous nature, short half-life, and low stability of NO present challenges for its clinical application. To address these issues, this study introduces innovative S-nitrosoglutathione (GSNO)-loaded asymmetric alginate (SA) hydrogel (GSNO-SA) as novel solution treating infected chronic wounds. The designed with layer-by-layer melting-permeation crosslinking approach, forming dense upper layer sparse lower structure, effectively promoting exudate management while delaying release. results demonstrate GSNO-SA extends release up to 48 h, exhibits rapid absorption (72.3 ± 1.5% equilibrium swelling after 5 min), significant antibacterial activity (over 90% rate against E. coli S. aureus), anti-inflammatory effects (marked reduction TNF-α expression), promotes angiogenesis (90.00 5.92% migration at h). Additionally, animal studies show accelerates healing, achieving 99.2 0.1% closure 14 days. Histological immunohistochemical evaluations further confirm ability regulate inflammation (13.34-fold upregulation CD163) promote (3.02-fold α-SMA). Theoretically, design provides strategy developing exudate-managing dressings by integrating controlled hierarchical pore structures.

Язык: Английский

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Nitric‐Oxide‐Enhanced Positively Charged Semiconductor Conjugated Polymer Composite Nanomaterials for Antibiofilm In Vivo

Advanced Functional Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 7, 2024

Abstract Bacterial biofilms often lead to persistent infections because they provide a protective barrier and reproductive microenvironment for bacteria. Biofilms reduce the therapeutic effects of antibiotics can easily emergence multidrug‐resistant Therefore, development new materials antibiofilm with synergistic is crucial. In this study, positively charged near‐infrared‐responsive nanoparticles (TDPPB) are synthesized control release delivery nitric oxide (NO) gas. A combination NO photothermal therapy (PTT) used enhance performance TDPPB. The positive charge TDPPB induces adhere surface Through 808 nm laser irradiation, local high temperature triggers efficient from donor (BNN 6) in integrates NO, PTT presents good activity against MRSA Escherichia coli ( E. ) biofilms. demonstrates excellent biosafety both vivo vitro, shows properties biofilm‐infected mice, promotes healing surface‐infected sites vivo. Because these advantages, be as potential agent biofilm biomedical field.

Язык: Английский

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