Abstract
In
pharmaceuticals,
the
structural
and
functional
alterations
induced
by
biotransformation
are
well‐documented.
Many
pharmaceuticals
exist
in
various
crystal
forms,
which
govern
their
transformation
significantly
impact
activity.
However,
field
of
inorganic
nanomedicine,
there
is
a
paucity
research
focusing
on
influence
form‐dependent
“metabolism”
(transformation)
activity
biomechanism.
This
study
delves
into
distinct
performances
two
forms
manganese
sulfide
(MnS),
namely
α‐MnS
γ‐MnS,
bacteria‐infected
diabetic
wound
healing.
initial
stage
wound,
where
environment
neutral
to
slightly
alkaline,
MnS
partially
converts
Mn
x
O
y
(comprising
2
3
4
)
concurrently
produces
hydrogen
(H
S);
conversion
efficiency
γ‐MnS
surpasses
that
α‐MnS.
Additionally,
more
soluble
than
α‐MnS,
allows
it
generate
2+
.
These
components
collectively
contribute
superior
bacteriostatic
properties
MnS.
related
cells,
stimulates
production
collagen
I
vascular
endothelial
growth
factor
(VEGF),
promote
M1
macrophages
polarizing
M2
phenotype,
for
extracellular
matrix
(ECM)
remodeling.
Notably,
different
products
have
functions.
Consequently,
dependent
its
original
form
solubility
efficiency.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 7, 2024
Abstract
Bacterial
biofilms
often
lead
to
persistent
infections
because
they
provide
a
protective
barrier
and
reproductive
microenvironment
for
bacteria.
Biofilms
reduce
the
therapeutic
effects
of
antibiotics
can
easily
emergence
multidrug‐resistant
Therefore,
development
new
materials
antibiofilm
with
synergistic
is
crucial.
In
this
study,
positively
charged
near‐infrared‐responsive
nanoparticles
(TDPPB)
are
synthesized
control
release
delivery
nitric
oxide
(NO)
gas.
A
combination
NO
photothermal
therapy
(PTT)
used
enhance
performance
TDPPB.
The
positive
charge
TDPPB
induces
adhere
surface
Through
808
nm
laser
irradiation,
local
high
temperature
triggers
efficient
from
donor
(BNN
6)
in
integrates
NO,
PTT
presents
good
activity
against
MRSA
Escherichia
coli
(
E.
)
biofilms.
demonstrates
excellent
biosafety
both
vivo
vitro,
shows
properties
biofilm‐infected
mice,
promotes
healing
surface‐infected
sites
vivo.
Because
these
advantages,
be
as
potential
agent
biofilm
biomedical
field.
ACS Biomaterials Science & Engineering,
Год журнала:
2024,
Номер
10(7), С. 4195 - 4226
Опубликована: Май 16, 2024
Diabetic
foot
ulcers
(DFU)
are
chronic,
refractory
wounds
caused
by
diabetic
neuropathy,
vascular
disease,
and
bacterial
infection,
have
become
one
of
the
most
serious
persistent
complications
diabetes
mellitus
because
their
high
incidence
difficulty
in
healing.
Its
malignancy
results
from
a
complex
microenvironment
that
includes
series
unfriendly
physiological
states
secondary
to
hyperglycemia,
such
as
recurrent
infections,
excessive
oxidative
stress,
inflammation,
ischemia
hypoxia.
However,
current
common
clinical
treatments,
antibiotic
therapy,
insulin
surgical
debridement,
conventional
wound
dressings
all
drawbacks,
suboptimal
outcomes
exacerbate
financial
physical
burdens
patients.
Therefore,
development
new,
effective
affordable
treatments
for
DFU
represents
top
priority
improve
quality
life
In
recent
years,
nanozymes-based
therapy
systems
been
attracting
extensive
interest
integrating
unique
advantages
nanomaterials
natural
enzymes.
Compared
with
enzymes,
nanozymes
possess
more
stable
catalytic
activity,
lower
production
cost
greater
maneuverability.
Remarkably,
many
multienzyme
activities
can
cascade
multiple
enzyme-catalyzed
reactions
simultaneously
throughout
recovery
process
DFU.
Additionally,
favorable
photothermal-acoustic
properties
be
exploited
further
enhancement
therapeutic
effects.
this
review
we
first
describe
characteristic
pathological
DFU,
then
discuss
mechanisms
applications
healing,
finally,
highlight
challenges
perspectives
nanozyme
treatment.
New Journal of Chemistry,
Год журнала:
2024,
Номер
48(25), С. 11465 - 11475
Опубликована: Янв. 1, 2024
A
good
biocompatible
multifunctional
Ti
implant
was
constructed,
which
exhibits
synergistic
antibacterial
activity
through
photothermal
and
NO
effects,
promotes
osseointegration.
Abstract
In
pharmaceuticals,
the
structural
and
functional
alterations
induced
by
biotransformation
are
well‐documented.
Many
pharmaceuticals
exist
in
various
crystal
forms,
which
govern
their
transformation
significantly
impact
activity.
However,
field
of
inorganic
nanomedicine,
there
is
a
paucity
research
focusing
on
influence
form‐dependent
“metabolism”
(transformation)
activity
biomechanism.
This
study
delves
into
distinct
performances
two
forms
manganese
sulfide
(MnS),
namely
α‐MnS
γ‐MnS,
bacteria‐infected
diabetic
wound
healing.
initial
stage
wound,
where
environment
neutral
to
slightly
alkaline,
MnS
partially
converts
Mn
x
O
y
(comprising
2
3
4
)
concurrently
produces
hydrogen
(H
S);
conversion
efficiency
γ‐MnS
surpasses
that
α‐MnS.
Additionally,
more
soluble
than
α‐MnS,
allows
it
generate
2+
.
These
components
collectively
contribute
superior
bacteriostatic
properties
MnS.
related
cells,
stimulates
production
collagen
I
vascular
endothelial
growth
factor
(VEGF),
promote
M1
macrophages
polarizing
M2
phenotype,
for
extracellular
matrix
(ECM)
remodeling.
Notably,
different
products
have
functions.
Consequently,
dependent
its
original
form
solubility
efficiency.
