Bioactive Materials, Год журнала: 2024, Номер 46, С. 213 - 228
Опубликована: Дек. 16, 2024
Язык: Английский
New Journal of Chemistry, Год журнала: 2024, Номер 48(25), С. 11465 - 11475
Опубликована: Янв. 1, 2024
A good biocompatible multifunctional Ti implant was constructed, which exhibits synergistic antibacterial activity through photothermal and NO effects, promotes osseointegration.
Язык: Английский
Процитировано
1
Small, Год журнала: 2024, Номер unknown
Опубликована: Окт. 14, 2024
Abstract In pharmaceuticals, the structural and functional alterations induced by biotransformation are well‐documented. Many pharmaceuticals exist in various crystal forms, which govern their transformation significantly impact activity. However, field of inorganic nanomedicine, there is a paucity research focusing on influence form‐dependent “metabolism” (transformation) activity biomechanism. This study delves into distinct performances two forms manganese sulfide (MnS), namely α‐MnS γ‐MnS, bacteria‐infected diabetic wound healing. initial stage wound, where environment neutral to slightly alkaline, MnS partially converts Mn x O y (comprising 2 3 4 ) concurrently produces hydrogen (H S); conversion efficiency γ‐MnS surpasses that α‐MnS. Additionally, more soluble than α‐MnS, allows it generate 2+ . These components collectively contribute superior bacteriostatic properties MnS. related cells, stimulates production collagen I vascular endothelial growth factor (VEGF), promote M1 macrophages polarizing M2 phenotype, for extracellular matrix (ECM) remodeling. Notably, different products have functions. Consequently, dependent its original form solubility efficiency.
Язык: Английский
Процитировано
1
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(7), С. 4195 - 4226
Опубликована: Май 16, 2024
Diabetic foot ulcers (DFU) are chronic, refractory wounds caused by diabetic neuropathy, vascular disease, and bacterial infection, have become one of the most serious persistent complications diabetes mellitus because their high incidence difficulty in healing. Its malignancy results from a complex microenvironment that includes series unfriendly physiological states secondary to hyperglycemia, such as recurrent infections, excessive oxidative stress, inflammation, ischemia hypoxia. However, current common clinical treatments, antibiotic therapy, insulin surgical debridement, conventional wound dressings all drawbacks, suboptimal outcomes exacerbate financial physical burdens patients. Therefore, development new, effective affordable treatments for DFU represents top priority improve quality life In recent years, nanozymes-based therapy systems been attracting extensive interest integrating unique advantages nanomaterials natural enzymes. Compared with enzymes, nanozymes possess more stable catalytic activity, lower production cost greater maneuverability. Remarkably, many multienzyme activities can cascade multiple enzyme-catalyzed reactions simultaneously throughout recovery process DFU. Additionally, favorable photothermal-acoustic properties be exploited further enhancement therapeutic effects. this review we first describe characteristic pathological DFU, then discuss mechanisms applications healing, finally, highlight challenges perspectives nanozyme treatment.
Язык: Английский
Процитировано
0
Dalton Transactions, Год журнала: 2024, Номер 53(30), С. 12783 - 12796
Опубликована: Янв. 1, 2024
Over the past two decades, following discovery of important biological roles carbon monoxide (CO), metal carbonyl complexes have been intensively studied as CO-releasing molecules (CORMs) for therapeutic applications. To improve properties "bare" low molecular weight CORMs, attention has drawn to conjugating CORMs with macromolecular and inorganic scaffolds produce materials (CORMAs) capable storing delivering large payloads gasotransmitter. A significant obstacle is obtain CORMAs that retain beneficial features parent CORMs. In present work, a crystalline metal-organic framework (MOF) formulated Mo(CO)
Язык: Английский
Процитировано
0
Bioactive Materials, Год журнала: 2024, Номер 46, С. 213 - 228
Опубликована: Дек. 16, 2024
Язык: Английский
Процитировано
0