Recent Advances in Metal–Organic Frameworks as Oxidase Mimics: A Comprehensive Review on Rational Design and Modification for Enhanced Sensing Applications
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 30, 2024
Metal–organic
frameworks
(MOFs)
have
emerged
as
innovative
nanozyme
mimics,
particularly
in
the
area
of
oxidase
catalysis,
outperforming
traditional
MOF-based
peroxidase
and
other
nanomaterial-based
systems.
This
review
explores
various
advantages
that
MOFs
offer
terms
catalytic
activity,
low-cost,
stability,
structural
versatility.
With
a
primary
focus
on
their
application
biochemical
sensing,
oxidases
demonstrated
remarkable
utility,
prompting
thorough
exploration
design
modification
strategies.
Moreover,
aims
to
provide
comprehensive
analysis
strategies
employed
rational
MOF
structures
optimize
key
parameters
such
sensitivity,
selectivity,
stability
context
sensors.
Through
an
exhaustive
examination
recent
research
developments,
this
article
seeks
insights
into
nuanced
interplay
between
performance,
shedding
light
mechanisms
underpin
effectiveness
mimics.
Finally,
addresses
challenges
opportunities
associated
with
aiming
drive
further
advancements
structure
development
highly
effective
sensors
for
diverse
applications.
Язык: Английский
Advances in the application of smart materials in the treatment of ophthalmic diseases
Biomaterials,
Год журнала:
2025,
Номер
unknown, С. 123316 - 123316
Опубликована: Апрель 1, 2025
Язык: Английский
Photothermal-Boosted chemodynamic nanoplatforms via MXene Supported Pt Single-Atom catalysts for Synergistic MRSA eradication and infected wound Regeneration
Xiaoshuai Sun,
Danyan Wang,
Shuai Ma
и другие.
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 162627 - 162627
Опубликована: Апрель 1, 2025
Язык: Английский
Dynamic multistage nanozyme hydrogel reprograms diabetic wound microenvironment: synergistic oxidative stress alleviation and mitochondrial restoration
Materials Today Bio,
Год журнала:
2025,
Номер
32, С. 101780 - 101780
Опубликована: Апрель 17, 2025
Chronic
diabetic
wounds
remain
a
significant
clinical
challenge
due
to
persistent
bacterial
infections,
oxidative
stress,
impaired
angiogenesis,
and
mitochondrial
dysfunction.
Traditional
therapies
often
fail
address
these
interrelated
pathological
factors,
highlighting
the
urgent
need
for
innovative
solutions.
Here,
we
present
Mn-ZIF@GOx/BC
(MZGB)
hydrogel
system,
where
Mn-ZIF@GOx
(MZG)
nanozymes
are
successfully
integrated
into
cellulose
(BC)
via
hydrogen
bonding
electrostatic
interactions.
The
MZGB
lowers
wound
pH
by
oxidizing
excess
glucose
gluconic
acid.
It
exhibits
strong
ROS
scavenging
capabilities
through
its
superoxide
dismutase
catalase-like
activities,
while
simultaneously
providing
oxygen.
By
restoring
redox
homeostasis,
it
protects
function
enhances
cellular
energy
metabolism.
reprogramming
macrophages,
creates
favorable
immune
microenvironment,
significantly
promoting
angiogenesis
paracrine
mechanisms.
This
facilitates
cell-to-cell
communication,
forming
positive
feedback
loop.
Moreover,
demonstrates
ROS-independent
antibacterial
properties.
BC
ensures
adhesion
moisture
regulation,
protective
barrier
maintaining
an
optimal
environment.
multifunctional
represents
promising
nanotherapeutic
approach
efficiently
treating
precisely
regulating
microenvironment.
Язык: Английский
Dumbbell-Shaped Gold Nanorod@Mesoporous Palladium Nanozymes for NIR-II-Triggered Photocatalytic Amplification and Trimodal Cancer Therapy
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 9, 2025
While
nanozyme-mediated
catalytic
therapy
holds
promise
for
precision
oncology,
achieving
spatiotemporal
control
over
enzymatic
activity
and
synergistic
therapeutic
amplification
in
the
biologically
favorable
second
near-infrared
window
(NIR-II)
remains
an
unmet
challenge.
In
this
study,
we
present
a
breakthrough
plasmonic
heterojunction
engineering
through
rational
design
of
asymmetric
dumbbell-shaped
Au
nanorod@end-mesoporous
Pd
architectures
that
establish
high
density
hotspots
at
mesopore
sites.
Unlike
conventional
core-shell
configurations
(Au@mesoPd)
showing
negligible
NIR-II
response,
our
heterostructure
demonstrates
nearly
200%
enhancement
peroxidase-like
under
1064
nm
excitation
precisely
engineered
hot
electron
dynamics.
Time-resolved
absorption
spectroscopy
COMSOL
simulations
reveal
unique
terminal
deposition
mesoporous
domains
creates
high-density
electromagnetic
(>200%
field
vs
core-shell)
while
maintaining
efficient
charge
transfer
channels─synergistically
boosting
both
carrier
generation
turnover
frequency.
This
nanoarchitecture
integrates
photoacoustic
navigation
with
triple
modality,
combining
plasmon-enhanced
photothermal
ablation,
Pd-mediated
therapy,
chemotherapy,
which
great
potential
NIR-II-triggered
multimodal
cancer
therapy.
Язык: Английский
Revolutionizing nanozyme technology with metal-organic frameworks: Classification, catalytic mechanisms, regulation and applications in biotechnology
Chemical Engineering Journal,
Год журнала:
2024,
Номер
unknown, С. 156850 - 156850
Опубликована: Окт. 1, 2024
Язык: Английский
Therapeutic Frontiers in Nanozyme-Based Cancer Treatment: Advances, Challenges, and Future Directions
Vidyodaya Journal of Science,
Год журнала:
2024,
Номер
27(02)
Опубликована: Дек. 30, 2024
Nanozymes,
artificial
nanomaterials
mimicking
enzyme
activity,
are
at
the
forefront
of
innovative
cancer
therapies,
particularly
in
chemodynamic
therapy
(CDT),
photodynamic
(PDT),
and
photothermal
(PTT).
Their
capacity
to
selectively
generate
reactive
oxygen
species
under
tumor-specific
conditions,
including
low
pH
high
H₂O₂
levels,
facilitates
targeted
induction
cell
death
while
minimizing
damage
healthy
tissues.
When
integrated
with
PDT
or
PTT,
nanozymes
enhance
oxidative
stress
promote
immunogenic
death,
further
amplifying
anti-tumor
immune
responses.
Recent
advances
single-atom
intelligent
have
shown
promise
overcoming
therapeutic
limitations,
such
as
tumor
hypoxia
suppression
modulating
microenvironment
boost
treatment
efficacy.
Additionally,
ongoing
preclinical
clinical
evaluations
highlight
potential
synergistically
immunotherapy
outcomes.
advantages
over
traditional
enzymes,
stability,
tunability,
cost-effectiveness,
ability
maintain
catalytic
activity
hostile
environments,
position
transformative
agents
therapy.
However,
their
translation
faces
significant
challenges,
biocompatibility
concerns,
delivery
inefficiencies
sites,
stringent
regulatory
hurdles,
which
require
comprehensive
research
solutions
address.
Despite
these
advancements
nanozyme
design
functionalization
continue
pave
way
for
more
effective
safer
applications
will
be
discussed
detail
this
review.Keywords:
Cancer
therapy,
Nanomaterial,
ROS,
(PTT)
Язык: Английский