Recent Progress in Chitosan-Based Nanoparticles for Drug Delivery: A Review on Modifications and Therapeutic Potential

Journal of drug targeting, Год журнала: 2025, Номер unknown, С. 1 - 51

Опубликована: Май 7, 2025

Chitosan, obtained from chitin by deacetylation, is a versatile biopolymer known for its biocompatibility, biodegradability, and environmental friendliness. Combined with chemical physical modifiability, these properties have made chitosan an important material in biomedical pharmaceutical fields, especially drug delivery systems. Chitosan-based nanomaterials exhibit enhanced functions through various modifications such as thiolation, acetylation, carboxylation, phosphorylation, well enzymatic approaches. These address inherent limitations poor solubility, limited acid resistance, insufficient mechanical strength, expanding the applications of tissue engineering, gene therapy, vaccine delivery, wound healing, bioimaging.This review provides in-depth analysis structure, physicochemical modification strategies chitosan. It also explores current methodologies preparing nanoparticles, along loading release techniques. Various targeting employed chitosan-based systems are examined detail. To illustrate clinical relevance approaches, representative examples recent therapeutic studies included. Moreover, it highlights future research directions innovation potential materials.

Язык: Английский

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Juniper Berry Oil as a Functional Additive in Chitosan–Water Kefiran–Paramylon Porous Sponges: Structural, Physicochemical, and Protein Interaction Insights

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(11), С. 5314 - 5314

Опубликована: Май 31, 2025

This study reports on the design and development of novel porous biomaterials based chitosan, water kefiran, paramylon, enriched with various concentrations juniper berry oil (JBO). The materials were obtained by freeze-drying comprehensively characterized. analyses included morphological evaluation (SEM porosity), physicochemical tests (swelling rate, vapor transmission roughness), mechanical (tensile strength, Young’s modulus, elongation at break), biodegradability under physiological conditions. Moreover, functional behavior was evaluated assessing their antioxidant anti-inflammatory activity, as well interactions selected proteins (human serum albumin fibrinogen) relevant to biological responses. It found that presence JBO affects internal structure improves properties in a concentration-dependent manner. is first investigate combined use paramylon single system JBO. results confirm importance such biopolymer sponges promising platforms for applications where appropriate bioactive are desired.

Язык: Английский

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Mapping the technological impact of chitosan research through patent citations

Materials Today Communications, Год журнала: 2024, Номер 41, С. 110334 - 110334

Опубликована: Сен. 6, 2024

Язык: Английский

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Mechanisms of Genipin and MCNT effects on the actuation properties and failure of chitosan gel bionic artificial muscles

Journal of Materials Science Materials in Electronics, Год журнала: 2024, Номер 35(19)

Опубликована: Июль 1, 2024

Язык: Английский

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