Fundamental Research,
Год журнала:
2023,
Номер
5(2), С. 654 - 662
Опубликована: Апрель 20, 2023
Pyridylphosphonium
salts,
which
are
readily
available
and
air
thermally
stable,
have
been
used
to
effectively
synthesize
structurally
diverse
pyridines.
Herein,
we
report
the
pnictogen
bonding
(PnB)
enabled
photoactivation
of
pyridylphosphonium
salts
with
catalytic
potassium
carbonate
generate
pyridyl
radical
for
pyridine
synthesis.
Remarkably,
this
light-driven
transformation
allowed
chiral
pool
synthesis
excellent
chirality
retention,
giving
a
wide
range
selenium-containing
On
basis
our
combined
computational
experimental
studies,
propose
that
PnB
between
enables
access
photoactive
charge
transfer
complex,
is
able
undergo
single
electron
its
transformation.
Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
67(10), С. 7759 - 7787
Опубликована: Май 8, 2024
There
is
an
urgent
need
to
develop
safer
and
more
effective
modalities
for
the
treatment
of
a
wide
range
pathologies
due
increasing
rates
drug
resistance,
undesired
side
effects,
poor
clinical
outcomes,
etc.
Throughout
years,
selenium
(Se)
has
attracted
great
deal
attention
its
important
role
in
human
health.
Besides,
growing
body
work
unveiled
that
inclusion
Se
motifs
into
number
molecules
promising
strategy
obtaining
novel
therapeutic
agents.
In
current
Perspective,
we
have
gathered
most
recent
literature
related
incorporation
different
moieties
scaffolds
known
drugs
their
feasible
pharmaceutical
applications.
addition,
highlight
representative
examples
as
well
provide
our
perspective
on
possible
future
directions,
promises,
opportunities,
challenges
this
ground-breaking
area
research.
Molecules,
Год журнала:
2022,
Номер
27(5), С. 1597 - 1597
Опубликована: Фев. 28, 2022
Organoselenium
compounds
have
been
successfully
applied
in
biological,
medicinal
and
material
sciences,
as
well
a
powerful
tool
for
modern
organic
synthesis,
attracting
the
attention
of
scientific
community.
This
great
success
is
mainly
due
to
breaking
paradigm
demonstrated
by
innumerous
works,
that
selenium
were
toxic
would
potential
impact
on
environment.
In
this
update
review,
we
highlight
relevance
these
several
fields
research
possibility
synthesize
them
through
more
environmentally
sustainable
methodologies,
involving
catalytic
processes,
flow
chemistry,
electrosynthesis,
use
alternative
energy
sources,
including
mechanochemical,
photochemistry,
sonochemical
microwave
irradiation.
Organic Letters,
Год журнала:
2022,
Номер
24(29), С. 5345 - 5350
Опубликована: Июль 19, 2022
The
organoselenium-catalyzed
amination
of
alkenes
is
a
promising
way
to
construct
functionalized
amines.
However,
the
use
chemical
oxidants
and
unavoidable
formation
allylic
amine
or
enamine
are
two
main
limitations
these
methodologies.
Against
this
background,
we
herein
report
an
electro-selenocatalytic
regime
for
hydroazolylation
with
azoles
under
external
oxidant-free
conditions
low
catalyst
loadings.
Moreover,
protocol
enables
generation
amines
without
vinyl
substituents.
Organic Chemistry Frontiers,
Год журнала:
2023,
Номер
10(19), С. 4972 - 5027
Опубликована: Янв. 1, 2023
This
review
comprehensively
summarizes
the
dichalcogenative
functionalization
of
unsaturated
compounds
over
past
decade.
The
scopes,
limitations
and
detailed
reaction
mechanisms
are
also
discussed.
New Journal of Chemistry,
Год журнала:
2023,
Номер
47(12), С. 5598 - 5602
Опубликована: Янв. 1, 2023
We
hereby
present
an
original
and
sustainable
synthetic
methodology
for
the
synthesis
of
3-selanyl-isoflavones
from
2-hydroxyphenyl
enaminones
diorganoyl
diselenides.
The Journal of Organic Chemistry,
Год журнала:
2023,
Номер
88(13), С. 8992 - 9003
Опубликована: Июнь 11, 2023
A
visible-light-induced
efficient
methodology
has
been
developed
for
the
C–H
selenylation
of
pyrazolo[1,5-a]pyrimidine
derivatives
employing
erythrosine
B
as
photocatalyst.
This
is
first
report
on
regioselective
pyrazolo[1,5-a]pyrimidines.
The
efficiency
this
different
electron-rich
heterocycles
like
pyrazole,
indole,
imidazo[1,2-a]pyridine,
imidazo[2,1-b]thiazole,
and
4-(phenylamino)-2H-chromen-2-one
also
demonstrated.
exploration
a
photocatalyst
with
simple
mild
procedure,
wide
substrate
scope,
practical
applicability
employment
eco-friendly
energy,
oxidant,
solvent
are
attractive
characteristics
methodology.
Organic & Biomolecular Chemistry,
Год журнала:
2022,
Номер
20(8), С. 1754 - 1758
Опубликована: Янв. 1, 2022
Visible-light
photocatalytic
trifluoromethylselenolation
of
ortho
-hydroxyarylenaminones
is
reported,
which
provides
a
green
protocol
for
the
efficient
and
rapid
synthesis
trifluoromethylselenylated
chromones.
Frontiers in Chemistry,
Год журнала:
2022,
Номер
10
Опубликована: Май 17, 2022
We
report
an
electrochemical
oxidative
intramolecular
cyclization
reaction
between
2-alkynylphenol
derivatives
and
different
diselenides
species
to
generate
a
wide
variety
of
substituted-benzo[b]furans.
Driven
by
the
galvanostatic
electrolysis
assembled
in
undivided
cell,
it
provided
efficient
transformation
into
oxidant-,
base-,
metal-free
conditions
open
system
at
room
temperature.
With
satisfactory
functional
group
compatibility,
products
were
obtained
good
excellent
yields.
