Asian Journal of Organic Chemistry,
Год журнала:
2021,
Номер
11(2)
Опубликована: Дек. 15, 2021
Abstract
An
efficient
and
environmentally‐friendly
synthesis
of
aryl
ketones
through
the
electrochemical
catalytic
hydrocarbonylation
arylacetylene
is
demonstrated.
The
reaction
conditions
are
mild
without
transition
metal
catalysts,
extra
oxidants,
or
strong
acids
involved.
By
using
Selectfluor
as
additive,
this
transformation
exhibits
good
functional‐group
tolerance.
ketone
product
obtained
with
up
to
90%
isolated
yield
in
mixed
electrolytes
acetonitrile
water.
This
method
may
open
a
new
window
for
green
from
arylacetylenes.
Sustainable Chemistry,
Год журнала:
2022,
Номер
3(4), С. 430 - 454
Опубликована: Окт. 13, 2022
The
electrochemical
generation
of
highly
reactive
and
hazardous
bromine
under
controlled
conditions
as
well
the
reduction
surplus
oxidizers
reagent
waste
has
placed
synthesis
in
a
highlighted
position.
In
particular,
dibromination
bromofunctionalization
alkenes
alkynes
have
received
significant
attention,
forming
synthetically
important
derivatives
can
be
generated
from
bench-stable
safe
bromide
sources
“green”
conditions.
Readily
available
non-corrosive
salts
been
utilized
with
dual
role
both
supporting
electrolyte.
However,
this
trend
seems
to
change
preparation
organobromine
species.
review,
was
addressed
terms
their
sustainability.
The Chemical Record,
Год журнала:
2022,
Номер
23(1)
Опубликована: Сен. 20, 2022
Abstract
Isocyanides
are
well‐known
as
efficient
CO
surrogates
and
C1
synthons
in
modern
organic
synthesis.
Although
tremendous
efforts
have
been
devoted
to
fully
exploiting
the
reactivity
of
isocyanides,
these
transformations
primarily
limited
by
their
utilization
stoichiometric
toxic
chemical
oxidants.
With
recent
resurgence
electrochemistry,
which
has
considerably
laid
dormant
over
past
several
decades,
electrolysis
identified
a
green
powerful
tool
enrich
structural
diversity
solely
utilizing
electric
current
clean
inherently
safe
redox
equivalents
In
this
regard,
unique
isocyanides
studied
numerous
electrochemical
transformations.
This
review
comprehensively
highlights
most
relevant
progress
strategies
towards
functionalization
up
until
June
2022,
with
focus
on
reaction
outcomes
mechanisms.
ACS Sustainable Chemistry & Engineering,
Год журнала:
2021,
Номер
9(50), С. 16989 - 16996
Опубликована: Дек. 7, 2021
A
straightforward
one-pot
two-step
electrosynthesis
of
cinnoline
derivatives
from
ortho-alkynyl
acetophenones
and
sulfonyl
hydrazides
has
been
developed
through
the
organocatalytic
cascade
radical
cyclization
migration.
This
methodology
features
green
mild
reaction
conditions,
good
to
excellent
yield,
broad
functional
group
tolerance,
regioselectivity,
use
readily
available
substrates.
Moreover,
based
on
isotope
labeling,
trapping,
singlet
oxygen
superoxide
anion
inhibiting,
cyclic
voltammetry,
EPR
experiments,
a
possible
electrochemically
migration
process
was
proposed.
ACS Sustainable Chemistry & Engineering,
Год журнала:
2022,
Номер
10(10), С. 3288 - 3294
Опубликована: Март 3, 2022
A
straightforward
synthesis
of
azaheterocycles
has
been
developed
through
electrochemically
aerobic
oxidation
cyclization
using
a
user-friendly
undivided
electrolytic
cell
at
room
temperature
under
catalyst-free
conditions.
This
green
and
practical
electrosynthesis
strategy
features
good
functional
group,
diverse
electronic
steric
properties
tolerance.
On
the
basis
series
mechanistic
investigations,
including
isotope
labeling,
singlet
oxygen
inhibiting,
superoxide
radical
anion
radical-trapping,
cyclic
voltammetry
controlled
potential
electrolysis
experiments,
possible
N-centered
radical-initiated
mechanism
was
proposed.
Organic Letters,
Год журнала:
2023,
Номер
26(1), С. 166 - 171
Опубликована: Дек. 28, 2023
The
generation
of
peroxy
radicals
from
hydroperoxides
with
subsequent
selective
peroxidation
1,3-dicarbonyls
in
an
undivided
electrochemical
cell
under
constant
current
conditions
is
reported.
method
provides
a
variety
peroxy-containing
barbituric
acids
and
4-hydroxy-2(5H)-furanones
yields
up
to
74%.
Only
the
combination
anodic
cathodic
processes
efficient
by
generating
set
alkoxy
radicals.
NaNO3
acts
as
both
electrolyte
redox
mediator
radical
reactions.
ACS Sustainable Chemistry & Engineering,
Год журнала:
2023,
Номер
11(50), С. 17728 - 17738
Опубликована: Дек. 6, 2023
Electrochemical
radical
cascade
cyclization
has
been
recognized
as
a
powerful,
straightforward,
and
environmentally-friendly
synthetic
tool
to
give
highly
functionalized
polycyclic
aromatic
compounds
but
remains
challenging
difficult
because
of
the
instability
intermediates
under
electrolysis
conditions,
especially
using
user-friendly
undivided
cell.
Herein,
we
report
novel
electrosynthesis
pyridine-fused
N-heteroaromatics
through
dehydrogenative
alkoxylation
oxidant-free
conditions.
This
electrochemical
synthesis
methodology
features
green
mild
reaction
good
functional
group
tolerance,
use
readily
available
substrates.
Moreover,
attributed
flow
cells,
steady
production
large-scale
preparation
can
be
conveniently
achieved
only
small
amounts
electrolytes.
Beilstein Journal of Organic Chemistry,
Год журнала:
2024,
Номер
20, С. 1327 - 1333
Опубликована: Июнь 10, 2024
The
radical
hydroarylation
of
alkenes
is
an
efficient
strategy
for
accessing
linear
alkylarenes
with
high
regioselectivity.
Herein,
we
report
the
electroreductive
electron-deficient
and
styrene
derivatives
using
(hetero)aryl
halides
under
mild
reaction
conditions.
Notably,
present
proceeded
efficiency
transition-metal-catalyst-free
key
to
success
use
1,3-dicyanobenzene
as
a
redox
mediator
visible-light
irradiation,
which
effectively
suppresses
formation
simple
reduction,
i.e.,
hydrodehalogenation,
products
afford
desired
in
good
yields.
Mechanistic
investigations
proposed
that
reductive
radical-polar
crossover
pathway
likely
be
involved
this
transformation.
Chemistry - A European Journal,
Год журнала:
2024,
Номер
30(57)
Опубликована: Июль 31, 2024
Electrochemical
reactions
are
very
complex
and
involve
a
variety
of
physicochemical
processes.
Accurate
systematic
monitoring
intermediate
process
changes
during
the
reaction
is
essential
for
understanding
mechanism
electrochemical
basis
rational
design
new
reactions.
On-line
analysis
based
on
mass
spectrometry
(MS)
has
become
an
important
tool
studying
This
technique
different
ionization
sampling
means
realizes
on-line
by
establishing
electrochemistry-MS
(EC-MS)
coupling
devices.
In
particular,
it
provides
key
evidence
elucidating
capturing
identifying
reactive
intermediates.
review
will
categorize
various
EC-MS
devices
organic
systems
they
study,
highlighting
latest
research
progress
in
recent
years.
It
also
analyze
properties
look
forward
to
future
development
EC-MS.
