Fluorescent Fluorinated Materials: A Novel Material for Application in Photodynamic Therapy and Designing Chemical Sensors

Journal of Photochemistry and Photobiology C Photochemistry Reviews, Год журнала: 2024, Номер 60-61, С. 100677 - 100677

Опубликована: Сен. 24, 2024

Язык: Английский

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F-CPI: A Multimodal Deep Learning Approach for Predicting Compound Bioactivity Changes Induced by Fluorine Substitution

Journal of Medicinal Chemistry, Год журнала: 2024, Номер unknown

Опубликована: Дек. 20, 2024

Fluorine (F) substitution is a common method of drug discovery and development. However, there are no accurate approaches available for predicting the bioactivity changes after F-substitution, as effect on interactions between compounds proteins (CPI) remains mystery. In this study, we constructed data set with 111,168 pairs fluorine-substituted nonfluorine-substituted compounds. We developed multimodal deep learning model (F-CPI). comparison traditional machine popular CPI task models, accuracy, precision, recall F-CPI (∼90, ∼79, ∼45%) were higher than those GraphDTA (∼86, ∼58, ∼40%). The application structural optimization hit against SARS-CoV-2 3CL

Язык: Английский

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N‐Fluoroalkylated Morpholinos – a New Class of Nucleoside Analogues

Chemistry - A European Journal, Год журнала: 2022, Номер 29(11)

Опубликована: Ноя. 28, 2022

The first concise and efficient synthesis of some fluorine-containing morpholino nucleosides has been developed. One synthetic strategy was based on the oxidative ring cleavage vicinal diol unit uridine, cytidine adenosine guanosine derivatives, followed by cyclisation dialdehyde intermediates double reductive amination with fluorinated primary amines to obtain various N-fluoroalkylated morpholinos. Another approach involved diformyl ammonia source, dithiocarbamate formation desulfurization-fluorination diethylaminosulfur trifluoride yielding corresponding morpholine-based nucleoside analogues a N-CF3 element in their structure.

Язык: Английский

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Methods to Improve the Stability of Nucleic Acid-Based Nanomaterials

Current Drug Metabolism, Год журнала: 2023, Номер 24(5), С. 315 - 326

Опубликована: Май 1, 2023

Abstract: Nucleic acid strands can be synthesized into various nucleic acid-based nanomaterials (NANs) through strict base pairing. The self-assembled NANs are programmable, intelligent, biocompatible, non-immunogenic, and non-cytotoxic. With the rapid development of nanotechnology, application in biomedical fields, such as drug delivery biological sensing, has attracted wide attention. However, stability is often affected by cation concentrations, enzymatic degradation, organic solvents. This susceptibility to degradation one most important factors that have restricted NANs. denatured or degraded under conditions low presence, To deal with this issue, a lot methods been attempted improve NANs, including artificial acids, modification specific groups, encapsulation protective structures, etc. In review, we summarized relevant deeper understanding

Язык: Английский

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Synthesis of fluorinated carbocyclic pyrimidine nucleoside analogues

Organic & Biomolecular Chemistry, Год журнала: 2022, Номер 20(47), С. 9469 - 9489

Опубликована: Янв. 1, 2022

Synthesis of 6′-fluorinated carbauridine scaffolds enables access to related cytidine, ProTide and 2′-deoxy analogues, alongside preliminary exploration their biological capabilities in cancer cell viability assays.

Язык: Английский

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