Visible-light-induced cascade reaction: a sustainable approach towards molecular complexity
Organic & Biomolecular Chemistry,
Год журнала:
2023,
Номер
21(8), С. 1591 - 1628
Опубликована: Янв. 1, 2023
Photoredox
catalysis
has
demonstrated
rapid
evolution
in
the
field
of
synthetic
organic
chemistry.
On
other
hand,
splendour
cascade
reactions
providing
complex
molecular
architectures
renders
them
a
cutting-edge
research
area.
Therefore,
merging
photocatalysis
with
synthesis
brings
out
paradigm
immense
potential.
The
development
photocascade
for
target
molecule
particular
skeleton
and
stereochemical
framework
presents
certain
challenges
but
provides
robust
environmentally
benign
alternative.
This
comprehensive
review
assembles
all
accomplishments
highlights
visible-light-induced
literature
coverage
up
to
October
2022.
Язык: Английский
Pyrazole: an Emerging Privileged Scaffold in Drug Discovery
Future Medicinal Chemistry,
Год журнала:
2023,
Номер
15(21), С. 2011 - 2023
Опубликована: Ноя. 1, 2023
Pyrazole
or
1H-pyrazole,
a
five-membered
1,2-diazole,
is
found
in
several
approved
drugs
and
some
bioactive
natural
products.
A
myriad
number
of
derivatives
this
small
molecule
have
been
reported
clinical
preclinical
studies
for
the
potential
treatment
diseases.
The
containing
pyrazole
nucleus
has
increased
significantly
last
10
years.
Some
best-selling
class
are
ibrutinib,
ruxolitinib,
axitinib,
niraparib
baricitinib,
used
to
treat
different
types
cancers;
lenacapavir
HIV;
riociguat
pulmonary
hypertension;
sildenafil
erectile
dysfunction.
Several
aniline-derived
compounds
as
potent
antibacterial
agents
with
selective
activity
against
methicillin-resistant
Staphylococcus
aureus
vancomycin-resistant
enterococci.
Here,
we
discuss
pyrazole-derived
up
September
2023.
Язык: Английский
C─H Functionalization of Heteroarenes via Electron Donor‐Acceptor Complex Photoactivation
ChemSusChem,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 8, 2024
C-H
Functionalization
of
heteroarenes
stands
as
a
potent
instrument
in
organic
synthesis,
and
with
the
incorporation
visible
light,
it
emerged
transformative
game-changer.
In
this
domain,
electron
donor-acceptor
(EDA)
complex,
formed
through
pairing
an
electron-rich
substrate
electron-accepting
molecule,
has
garnered
substantial
consideration
recent
years
due
to
related
avoidance
requirement
photocatalyst
well
oxidant.
EDA
complexes
can
undergo
photoactivation
under
mild
conditions
exhibit
high
functional
group
tolerance,
making
them
potentially
suitable
for
functionalization
biologically
relevant
heteroarenes.
This
review
article
provides
overview
advancements
field
via
complex
literature
coverage
up
April,
2024.
Язык: Английский
Transition-metal-catalyzedorthoC–H functionalization of 2-arylquinoxalines
Organic & Biomolecular Chemistry,
Год журнала:
2022,
Номер
20(37), С. 7361 - 7376
Опубликована: Янв. 1, 2022
This
work
systematically
summarizes
the
recent
advances
in
ortho
C–H
functionalization
of
2-arylquinoxalines,
with
literature
coverage
from
2010
to
2022.
Язык: Английский
MICROWAVE-ASSISTED FUNCTIONALIZATION OF INDAZOLES: AN OVERVIEW
RASAYAN Journal of Chemistry,
Год журнала:
2023,
Номер
16(03), С. 1560 - 1574
Опубликована: Янв. 1, 2023
Indazole-based
heterocyclic
compounds
possessing
significant
medicinal
properties
form
the
basis
of
developing
several
pharmaceuticals.Microwave-assisted
organic
synthesis
is
one
most
effective
and
promising
techniques
from
perspective
green
chemistry,
as
it
increases
reaction
rates
yields
while
decreasing
wasteful
byproducts.Functionalization
indazole
derivatives
under
microwave
irradiation
achieving
tremendous
interest
in
recent
times.Various
cross-coupling
reactions
are
generally
utilized
during
microwave-assisted
functionalization
indazoles.This
review
article
chronologically
describes
different
types
indazoles
assisted
by
with
up-to-date
literature
coverage.
Язык: Английский