Recent Advances in the Multicomponent Synthesis of Heterocycles Using 5-Aminotetrazole
Synthesis,
Год журнала:
2024,
Номер
56(16), С. 2445 - 2461
Опубликована: Янв. 8, 2024
Abstract
The
unique
reactivity
and
beneficial
features
of
the
5-aminotetrazole
synthon
(1H-tetrazol-5-amine)
have
made
it
a
versatile
effective
building
block
in
synthesis
heterocyclic
compounds.
In
addition,
several
drugs
containing
this
scaffold
with
wide
array
biological
properties
been
already
introduced.
Heterocyclic
structures
are
backbone
many
biologically
active
industrially
important
5-Aminotetrazole
is
one
favored
synthons
used
preparation
heterocycle-bearing
compounds,
especially
multicomponent
synthesis.
This
review
highlights
comprehensive
overview
emerging
applications
as
key
component
frameworks
through
reactions,
reported
between
2017
July
2023.
1
Introduction
2
3
Tetrazolopyrimidine
Compounds
4
Spiro
5
Miscellaneous
6
Conclusion
Язык: Английский
Efficient Microwave Synthesis, Antibacterial, and Antifungal Evaluation of 1,4-Dihydropyrimido[1,2-a]benzimidazole Derivatives
Russian Journal of Organic Chemistry,
Год журнала:
2024,
Номер
60(S1), С. S171 - S179
Опубликована: Дек. 1, 2024
Язык: Английский
A synthesis of novel 5-methylsulfanylazolo[1,5-a]pyrimidin-7(4H)-ones and investigation of their chemical and cytotoxic properties
Chemistry of Heterocyclic Compounds,
Год журнала:
2024,
Номер
60(1-2), С. 52 - 57
Опубликована: Фев. 1, 2024
Язык: Английский
Pronounced Anti‐Inflammatory and Analgesic Activities of a Spirofuran‐Triazolo[1,5‐a]pyrimidine Scaffold Available via Biginelli Multicomponent Condensation
ChemistrySelect,
Год журнала:
2024,
Номер
9(36)
Опубликована: Сен. 1, 2024
Abstract
In
this
work,
a
series
of
phenyl‐derivatives
spirofuran‐triazolo[1,5‐
]pyrimidine
(
5
–
i
)
were
evaluated
for
their
anti‐inflammatory
and
analgesic
activities,
including
SAR
molecular
docking
studies.
The
cytotoxicity
compounds
was
studied
in
RAW
264.7
murine
macrophage
cell
line
by
MTT
assay.
Then,
those
with
viability
higher
than
70
%
tested
activity
at
non‐toxic
doses
evaluating
the
nitrite
level
supernatants
Griess
reagent.
Compounds
b
,
d
e,
g
demonstrated
significant
inhibition
production
49
%,
59
63
respectively
100
μM
(p<0.05),
whereas
56
seen
50
.
According
to
PGE
2
compound
showed
most
notable
effect
compared
control.
All
compounds,
particularly
e
f
reduced
potential
activity.
Seven
heterocycles
moderate
activities.
Molecular
predicts
modest
or
no
COX‐1.
Instead,
modelling
results
also
show
that
these
molecules
can
effectively
bind
enzymes
COX‐2
mPGES‐2.
However,
simulation
distinguished
key
role
2‐OH
group
stabilizing
inhibitor‐target
complex
only
case
binding
COX‐2.
Язык: Английский
Chemistry in Ukraine
The Chemical Record,
Год журнала:
2024,
Номер
24(2)
Опубликована: Янв. 29, 2024
Abstract
In
this
special
issue,
we
highlight
recent
advances
in
chemical
research
by
scientists
Ukraine,
as
well
their
compatriots
and
collaborators
outside
the
country.
Besides
spotlighting
contributions,
see
our
task
fostering
global
partnerships
multi‐,
inter‐,
trans‐disciplinary
collaborations,
including
much‐needed
co‐funded
projects
initiatives.
The
three
decades
of
renewed
Ukraine
independence
have
seen
rather
limited
integration
Ukrainian
(chemical)
science
into
communities.
[1]
At
same
time,
surge
collaborative
initiatives
between
European
Union
(EU)
echoes
unfolding
steps
towards
Ukraine's
full
participation
to
Horizon
Europe
Program.
This
recently
implemented
step
opens
enormous
possibilities
for
researchers
apply
diverse
EU
grants.
Moreover,
a
number
journal
issues
collections
were
launched
chemistry
(i.
e.,
Chemistry
Heterocyclic
Compounds
[2]
ChemistrySelect
[3]
).
Other
scientific
include
‘European
School
Ukrainians’
[4]
‘Kharkiv
Chemical
Seminar’
[5]
voluntary
aimed
at
engaging
international
research.
Язык: Английский
Advancements in the Synthesis of Triazolopyrimidines
Current Organic Chemistry,
Год журнала:
2024,
Номер
28(20), С. 1567 - 1578
Опубликована: Июнь 26, 2024
:
The
triazolopyrimidine
scaffold
indeed
holds
a
prominent
place
in
medicinal
chemistry
due
to
its
versatile
pharmacological
properties.
Researchers
have
explored
the
and
derivatives
for
various
therapeutic
applications.
unique
structure
of
has
made
it
valuable
template
designing
medicinally
active
molecules.
literature
is
full
studies
showcasing
synthesis
biological
activities
compounds
containing
ring,
either
fused
or
coupled
with
other
heterocycles.
aim
this
review
provide
comprehensive
general
summary
recent
advancements
(Year
2021
present).
Язык: Английский
Ugi bisamides based on pyrrolyl-β-chlorovinylaldehyde and their unusual transformations
Beilstein Journal of Organic Chemistry,
Год журнала:
2024,
Номер
20, С. 1773 - 1784
Опубликована: Июль 26, 2024
By
one-pot
four-
and
three-component
Ugi
reactions
involving
convertible
isocyanides
unexplored
pyrrole-containing
β-chlorovinylaldehyde,
a
small
library
of
20
bisamides
with
unusual
behavior
in
post-Ugi
transformations
was
prepared
characterized.
Surprisingly,
well-documented
approach
to
obtain
peptide-containing
carboxylic
acids
through
acid
hydrolysis
the
isocyanide
moiety
proceeded
an
unexpected
manner
our
case,
leading
formation
derivatives
amides
heterylidenepyruvic
acid.
An
optimized
synthetic
protocol
for
this
transformation
elaborated
plausible
sequence
elimination
2-chloroacetamide
conversion
β-chlorovinyl
fragment
into
vinyl
one
is
provided.
Язык: Английский
Synthesis of Hetaryl Substituted Pyrazolo[3,4-b]Quinolinone Systems by Multicomponent Cyclocondensation Reaction
Black Sea Journal of Engineering and Science,
Год журнала:
2024,
Номер
7(6), С. 1204 - 1216
Опубликована: Окт. 10, 2024
In
this
study,
the
synthesis
of
pyrazolo[3,4-b]quinolinone
compounds
was
carried
out
via
one-pot
three-component
reactions.
These
reactions
proceed
as
domino
processes,
making
them
easier
to
occur
than
conventional
multistep
organic
By
employing
method,
new
molecules
can
be
synthesized
in
a
single
step,
using
minimal
time
and
number
trials.
first
phase
two-step
heteroaromatic
carbaldehydes
(quinoline-8-carboxaldehyde
quinoline-4-carboxaldehyde)
were
prepared
used
substrates
subsequent
by
oxidation
8-methylquinoline
4-methylquinoline
with
selenium
dioxide,
mild
oxidant.
second
carbaldehyde
reacted
aminopyrazole
dimedone
anhydrous
ethanol
multicomponent
condensation
method
synthesize
six
heteryl-substituted
ring
system.
The
crude
products
obtained
excellent
yields
further
purified
crystallization.
structures
compounds,
which
found
completely
pure
result
chromatographic
studies,
elucidated
spectroscopic
methods
elemental
analysis.
Язык: Английский