Molecular Catalysis, Год журнала: 2024, Номер 572, С. 114733 - 114733
Опубликована: Дек. 9, 2024
Язык: Английский
Molecular Omics, Год журнала: 2024, Номер 20(4), С. 220 - 233
Опубликована: Янв. 1, 2024
This review initially presents relevant patient-derived models, including PDXs, PDOs, and PDEs. Subsequently, a comprehensive summary of single-cell analyses conducted on these models is provided.
Язык: Английский
Процитировано
25
MedComm, Год журнала: 2025, Номер 6(2)
Опубликована: Янв. 19, 2025
Abstract The patient‐derived xenograft (PDX) model is a crucial in vivo extensively employed cancer research that has been shown to maintain the genomic characteristics and pathological structure of patients across various subtypes, metastatic, diverse treatment histories. Various strategies utilized PDX models can offer valuable insights into mechanisms tumor progression, drug resistance, development novel therapies. This review provides comprehensive overview establishment applications models. We present an history current status models, elucidate construction methodologies for different tumors, conduct comparative analysis highlight distinct advantages limitations this relation other are elucidated domain comprehending underlying therapy, which highlights broad fields chemotherapy, targeted delivery systems, combination antibody–drug conjugates radiotherapy. Furthermore, with multiomics single‐cell analyses also emphasized. application clinical personalized medicine additionally
Язык: Английский
Процитировано
9
World Journal of Gastroenterology, Год журнала: 2025, Номер 31(12)
Опубликована: Март 26, 2025
Evidence on adherence, diagnostic performance and impact survival to intensive follow-up after surgery for colorectal cancer (CRC) is limited. To analyze the of surveillance colonoscopy, computed tomography (CT), tumor markers (TMs) in detecting CRC recurrence or metastasis during resection. Secondary objectives included degree adherence clinical practice guidelines recommendations factors associated with all-cause mortality. The single-center retrospective cohort study including patients undergoing curative resection stage I-III 2010-2015. Follow-up was performed using TMs every 6 months, yearly CT 5 years, colonoscopy at years 1 4. Demographic, primary data, results were collected. Of 574 included, 153 had recurrences metastases. this group, 136 (88.9%) diagnosed by CT, 10 (6.5%) 7 (4.6%) colonoscopy; only 67.8% showed elevation. Adherence 68.8% first 74% scan, 96.6% blood test; these values declined over time. Younger age diagnosis [odds ratio (OR) 0.93; 95%CI: 0.91-0.95], stages I-II (OR 0.38; 0.24-0.61), 0.30; 0.20-0.46) independently lower risk death years. scan highest yield. low decreased follow-up. diagnosis, stage, 5-year
Язык: Английский
Процитировано
2
iScience, Год журнала: 2024, Номер 27(3), С. 109223 - 109223
Опубликована: Фев. 15, 2024
SummaryIn recent years, significant advancements have been made in the synthesis and application of 1,3-dienes. This specific structural motif has garnered attention from researchers materials science biology due to its unique aggregation-induced emission (AIE) properties extensive conjugation systems. The luminescent characteristics these compounds are notably influenced by geometry two double bonds. Therefore, it is essential consolidate stereoselective synthetic strategies for comprehensive review seeks elucidate diverse techniques employed attain stereo-control 1,3-diene-based AIE luminogens (AIEgens). Particular emphasis placed on comprehending determinants stereoselectivity exploring array substrates amenable methods. Furthermore, underscores exhibited their utility organic light-emitting diodes (OLEDs), stimuli-responsive materials, sensors, bioimaging, photodynamic therapy (PDT).Graphical abstract
Язык: Английский
Процитировано
7
Food & medicine homology., Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Organic Letters, Год журнала: 2024, Номер 26(25), С. 5323 - 5328
Опубликована: Июнь 17, 2024
Amino acids and aromatic nitrogen heterocycles are widely used in pharmaceuticals. Herein, we present an effective visible-light-driven thiobenzoic acid (TBA)-catalyzed decyanative C(sp3)–H heteroarylation of glycine derivatives. This process occurs under mild straightforward conditions, affording a range valuable yet challenging-to-obtain α-heteroaryl amino Moreover, this organocatalytic C(sp3)–C(sp2) bond formation reaction is applicable to the late-stage modification various short peptides.
Язык: Английский
Процитировано
6
Chemistry & Biodiversity, Год журнала: 2024, Номер 21(11)
Опубликована: Авг. 15, 2024
Abstract Pancreatobililary cancers are fatal solid tumors that pose a significant threat to human life. It is imperative investigate novel small molecule active compounds for controlling these cancers. Heterocyclic (e. g. gemcitabine) and multi‐substituted alkenes resveratrol) commonly applied in tumor treatment. Researchers have proposed the synthesis of new trisubstituted containing heteroaromatic rings by combining two scaffolds may be fresh strategy develop molecules. In this study, we utilized alkenyl bromide heteroaryl boronic acid as substrates, employing Suzuki coupling generate series triarylethylenes featuring nitrogen, oxygen, sulfur atoms. Through vitro experiments, results indicated some exhibited remarkable anti‐tumor efficacy IC50 [ 3be , GBC‐SD] =0.13 μM PANC‐1] =0.27 μM). The further demonstrated antitumor was dependent on heteroatom, π‐system, skeleton‐bonding site, substituent type.
Язык: Английский
Процитировано
4
Current Research in Biotechnology, Год журнала: 2024, Номер 7, С. 100228 - 100228
Опубликована: Янв. 1, 2024
Traditional Chinese Medicine (TCM) introduces a potentially effective strategy in the realm of cancer therapy, whereas network pharmacology provides reliable mechanism for clarifying complex interplay between active constituents and their corresponding targets. Although Dan-Shen-Yin (DSY) has demonstrated remarkable efficacy treatment various diseases, its potential anti-pancreatic effects underlying mechanisms remain unexplored. The present study aims to validate DSY both vivo vitro, while also elucidating through combination pharmacology, molecular docking, related experiments. effectiveness was validated using patient-derived xenograft (PDX) model, which chosen due capacity maintain essential histological genetic attributes primary tumor. Network predicted DSY, confirmed by vitro experiments showing inhibitory on proliferation, pro-apoptosis, migration, colony formation PC cells. Molecular docking studies further that components exhibited good nucleophilicity selected target proteins ability interact via hydrogen bonding Van der Waals forces. PDX model showed effectively inhibited tumor growth improved prognosis. Experiments conducted have is an PC. Moreover, mechanistic investigations provided evidence impede EGFR/SRC/STAT3 signaling pathway.
Язык: Английский
Процитировано
3
Biomedicines, Год журнала: 2024, Номер 12(8), С. 1804 - 1804
Опубликована: Авг. 8, 2024
(SO) is one of the most widely used plants in traditional medicine worldwide. In present study, effect an ethanolic extract
Язык: Английский
Процитировано
3
Biomedicines, Год журнала: 2024, Номер 12(10), С. 2199 - 2199
Опубликована: Сен. 26, 2024
Cancer, a complex group of diseases marked by uncontrolled cell growth and invasive behavior, is characterized distinct hallmarks acquired during tumor development. These hallmarks, first proposed Douglas Hanahan Robert Weinberg in 2000, provide framework for understanding cancer's complexity. Targeting them key strategy cancer therapy. It includes inhibiting abnormal signaling, reactivating suppressors, preventing invasion metastasis, angiogenesis, limiting replicative immortality, modulating the immune system, inducing apoptosis, addressing genome instability regulating cellular energetics. Usnic acid (UA) natural compound found lichens that has been explored as cytotoxic agent against cells different origins. Although exact mechanisms remain incompletely understood, UA presents promising therapeutic intervention. Understanding its impact on provides valuable insights into potential developing targeted multifaceted therapies. This article explores activity context disrupting origins based recent articles emphasize molecular this activity.
Язык: Английский
Процитировано
3