Molecular Catalysis, Год журнала: 2024, Номер 572, С. 114733 - 114733
Опубликована: Дек. 9, 2024
Язык: Английский
Molecular Omics, Год журнала: 2024, Номер 20(4), С. 220 - 233
Опубликована: Янв. 1, 2024
This review initially presents relevant patient-derived models, including PDXs, PDOs, and PDEs. Subsequently, a comprehensive summary of single-cell analyses conducted on these models is provided.
Язык: Английский
Процитировано
24
MedComm, Год журнала: 2025, Номер 6(2)
Опубликована: Янв. 19, 2025
Abstract The patient‐derived xenograft (PDX) model is a crucial in vivo extensively employed cancer research that has been shown to maintain the genomic characteristics and pathological structure of patients across various subtypes, metastatic, diverse treatment histories. Various strategies utilized PDX models can offer valuable insights into mechanisms tumor progression, drug resistance, development novel therapies. This review provides comprehensive overview establishment applications models. We present an history current status models, elucidate construction methodologies for different tumors, conduct comparative analysis highlight distinct advantages limitations this relation other are elucidated domain comprehending underlying therapy, which highlights broad fields chemotherapy, targeted delivery systems, combination antibody–drug conjugates radiotherapy. Furthermore, with multiomics single‐cell analyses also emphasized. application clinical personalized medicine additionally
Язык: Английский
Процитировано
5
iScience, Год журнала: 2024, Номер 27(3), С. 109223 - 109223
Опубликована: Фев. 15, 2024
SummaryIn recent years, significant advancements have been made in the synthesis and application of 1,3-dienes. This specific structural motif has garnered attention from researchers materials science biology due to its unique aggregation-induced emission (AIE) properties extensive conjugation systems. The luminescent characteristics these compounds are notably influenced by geometry two double bonds. Therefore, it is essential consolidate stereoselective synthetic strategies for comprehensive review seeks elucidate diverse techniques employed attain stereo-control 1,3-diene-based AIE luminogens (AIEgens). Particular emphasis placed on comprehending determinants stereoselectivity exploring array substrates amenable methods. Furthermore, underscores exhibited their utility organic light-emitting diodes (OLEDs), stimuli-responsive materials, sensors, bioimaging, photodynamic therapy (PDT).Graphical abstract
Язык: Английский
Процитировано
7
Organic Letters, Год журнала: 2024, Номер 26(25), С. 5323 - 5328
Опубликована: Июнь 17, 2024
Amino acids and aromatic nitrogen heterocycles are widely used in pharmaceuticals. Herein, we present an effective visible-light-driven thiobenzoic acid (TBA)-catalyzed decyanative C(sp3)–H heteroarylation of glycine derivatives. This process occurs under mild straightforward conditions, affording a range valuable yet challenging-to-obtain α-heteroaryl amino Moreover, this organocatalytic C(sp3)–C(sp2) bond formation reaction is applicable to the late-stage modification various short peptides.
Язык: Английский
Процитировано
6
Cancers, Год журнала: 2025, Номер 17(5), С. 813 - 813
Опубликована: Фев. 26, 2025
The emergence of cancer immunotherapy has revolutionized treatment, offering remarkable outcomes for patients across various malignancies. However, the heterogeneous response to underscores necessity understanding additional factors influencing treatment efficacy. Among these factors, human microbiota garnered significant attention its potential role in modulating immune response. Body: This review explores intricate relationship between and immunotherapy, highlighting recent advances mechanisms underlying microbial influence on outcomes. Insights into microbiome's impact not only deepen our pathogenesis but also hold promise personalized therapeutic strategies aimed at optimizing patient
Язык: Английский
Процитировано
0
World Journal of Gastroenterology, Год журнала: 2025, Номер 31(12)
Опубликована: Март 26, 2025
Evidence on adherence, diagnostic performance and impact survival to intensive follow-up after surgery for colorectal cancer (CRC) is limited. To analyze the of surveillance colonoscopy, computed tomography (CT), tumor markers (TMs) in detecting CRC recurrence or metastasis during resection. Secondary objectives included degree adherence clinical practice guidelines recommendations factors associated with all-cause mortality. The single-center retrospective cohort study including patients undergoing curative resection stage I-III 2010-2015. Follow-up was performed using TMs every 6 months, yearly CT 5 years, colonoscopy at years 1 4. Demographic, primary data, results were collected. Of 574 included, 153 had recurrences metastases. this group, 136 (88.9%) diagnosed by CT, 10 (6.5%) 7 (4.6%) colonoscopy; only 67.8% showed elevation. Adherence 68.8% first 74% scan, 96.6% blood test; these values declined over time. Younger age diagnosis [odds ratio (OR) 0.93; 95%CI: 0.91-0.95], stages I-II (OR 0.38; 0.24-0.61), 0.30; 0.20-0.46) independently lower risk death years. scan highest yield. low decreased follow-up. diagnosis, stage, 5-year
Язык: Английский
Процитировано
0
Molecular Diversity, Год журнала: 2025, Номер unknown
Опубликована: Март 28, 2025
Язык: Английский
Процитировано
0
Ultrasonics Sonochemistry, Год журнала: 2025, Номер unknown, С. 107367 - 107367
Опубликована: Апрель 1, 2025
Xanthenes are an important class of heterocycles in medicinal chemistry due to their diverse pharmacological properties. These tricyclic aromatic compounds, characterised by a dibenzo[b,e]pyran core with oxygen atom at central position, have gained significant attention for extensive applications. Beyond pharmaceuticals, xanthenes widely used textiles, food industries, electro-optical devices, dyes, and bioimaging agents. Xanthene derivatives, particularly 9-substituted xanthenes, exhibit wide range biological activities, including antiparasitic, antibacterial, antileishmanial, cytotoxic, neuroprotective, photophysical effects, making them valuable drug discovery. The xanthene scaffold is present various bioactive natural compounds such as mulgravanols A B, hermannol, (+)-myrtucommulone D, homapanicones blumeaxanthene II, acrotrione. Clinically relevant xanthene-based drugs include propantheline bromide (antimuscarinic), methantheline (antispasmodic), phloxine B (photosensitiser antimicrobial therapy). Thus, synthetic approaches been developed the construction ultrasound-assisted green methodologies gaining prominence. Ultrasound technique offers advantages over conventional methods, higher yields, faster reaction rates, improved selectivity under milder conditions. This review comprehensively explores synthesis functionalised derivatives eco-friendly alternative. To best our knowledge, this first in-depth focusing on methodology ultrasound irradiation.
Язык: Английский
Процитировано
0
Biomedicines, Год журнала: 2024, Номер 12(8), С. 1804 - 1804
Опубликована: Авг. 8, 2024
(SO) is one of the most widely used plants in traditional medicine worldwide. In present study, effect an ethanolic extract
Язык: Английский
Процитировано
3
Chemistry & Biodiversity, Год журнала: 2024, Номер 21(11)
Опубликована: Авг. 15, 2024
Abstract Pancreatobililary cancers are fatal solid tumors that pose a significant threat to human life. It is imperative investigate novel small molecule active compounds for controlling these cancers. Heterocyclic (e. g. gemcitabine) and multi‐substituted alkenes resveratrol) commonly applied in tumor treatment. Researchers have proposed the synthesis of new trisubstituted containing heteroaromatic rings by combining two scaffolds may be fresh strategy develop molecules. In this study, we utilized alkenyl bromide heteroaryl boronic acid as substrates, employing Suzuki coupling generate series triarylethylenes featuring nitrogen, oxygen, sulfur atoms. Through vitro experiments, results indicated some exhibited remarkable anti‐tumor efficacy IC50 [ 3be , GBC‐SD] =0.13 μM PANC‐1] =0.27 μM). The further demonstrated antitumor was dependent on heteroatom, π‐system, skeleton‐bonding site, substituent type.
Язык: Английский
Процитировано
3