Palladium-Catalyzed Stereospecific Glycosylation Enables Divergent Synthesis of N–O-Linked Glycosides DOI
Yujuan Wang, Yu Cheng, Xiaoma Tao

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

We present a versatile palladium-catalyzed glycosylation platform that enables facile access to structurally diverse N-O-linked glycosides with constantly excellent regio- and stereoselectivities. Importantly, this approach offers broad substrate scope, low catalyst loadings, outstanding chemoselectivity, allowing for the selective reaction of oximes/hydroximic acids over hydroxyl groups would otherwise pose challenges in conventional methods. The synthetic utility method is further exemplified through range transformations late-stage modification bioactive molecules. Overall, our provides an efficient toolkit synthesis glycosides, which will facilitate their subsequent biological evaluations.

Язык: Английский

Palladium-Catalyzed Stereospecific Glycosylation Enables Divergent Synthesis of N–O-Linked Glycosides DOI
Yujuan Wang, Yu Cheng, Xiaoma Tao

и другие.

Organic Letters, Год журнала: 2025, Номер unknown

Опубликована: Янв. 9, 2025

We present a versatile palladium-catalyzed glycosylation platform that enables facile access to structurally diverse N-O-linked glycosides with constantly excellent regio- and stereoselectivities. Importantly, this approach offers broad substrate scope, low catalyst loadings, outstanding chemoselectivity, allowing for the selective reaction of oximes/hydroximic acids over hydroxyl groups would otherwise pose challenges in conventional methods. The synthetic utility method is further exemplified through range transformations late-stage modification bioactive molecules. Overall, our provides an efficient toolkit synthesis glycosides, which will facilitate their subsequent biological evaluations.

Язык: Английский

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