Mechanistic Aspects of [3+2] Cycloaddition Reaction of Trifluoroacetonitrile with Diarylnitrilimines in Light of Molecular Electron Density Theory Quantum Chemical Study DOI Creative Commons
Agnieszka Łapczuk-Krygier, Mar Ríos‐Gutiérrez

Molecules, Год журнала: 2024, Номер 30(1), С. 85 - 85

Опубликована: Дек. 29, 2024

In this study, we investigated the [3+2] cycloaddition reaction of CF3CN (TFAN) with nitrilimine (NI) to produce 1,2,4-triazole and compared resulting isomers. We determined preferred pathway by examining electrophilic nucleophilic properties substrates, performing thermodynamic calculations for individual pathways, comparing them experimental results.

Язык: Английский

Design, Synthesis, and Bioactivity Evaluation of Novel Sulfone Derivatives Incorporating an 1,2,4-Triazole Moiety DOI
Jian Liu, Chuan He, B.K.H. Tan

и другие.

Russian Journal of General Chemistry, Год журнала: 2025, Номер 95(3), С. 757 - 763

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Poly(1,2,4-triazolium)s as the rising generation of functional poly(ionic liquid)s DOI Creative Commons
Xinghao Li, Éric Drockenmuller, Pierre Stiernet

и другие.

Progress in Polymer Science, Год журнала: 2025, Номер unknown, С. 101969 - 101969

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Progress and Prospects of Triazoles in Advanced Therapies for Parasitic Diseases DOI Creative Commons
Jaime A. Isern, Renzo Carlucci, Guillermo R. Labadié

и другие.

Tropical Medicine and Infectious Disease, Год журнала: 2025, Номер 10(5), С. 142 - 142

Опубликована: Май 20, 2025

Parasitic diseases represent a severe global burden, with current treatments often limited by toxicity, drug resistance, and suboptimal efficacy in chronic infections. This review examines the emerging role of triazole-based compounds, originally developed as antifungals, advanced antiparasitic therapy. Their unique structural properties, particularly those 1,2,3- 1,2,4-triazole isomers, facilitate diverse binding interactions favorable pharmacokinetics. By leveraging innovative synthetic approaches, such click chemistry (copper-catalyzed azide–alkyne cycloaddition) structure-based design, researchers have repurposed optimized triazole scaffolds to target essential parasite pathways, including sterol biosynthesis via CYP51 other novel enzymatic routes. Preclinical studies models Chagas disease, leishmaniasis, malaria, helminth infections demonstrate that derivatives like posaconazole, ravuconazole, DSM265 exhibit potent vitro vivo activity, although their primarily static effects success monotherapies cases. Combination strategies hybrid molecules demonstrated potential enhance mitigate resistance. Despite challenges achieving complete clearance managing interdisciplinary efforts across medicinal chemistry, parasitology, clinical research highlight significant triazoles components next-generation, patient-friendly regimens. These findings support further optimization evaluation agents improve for neglected parasitic diseases.

Язык: Английский

Процитировано

0
Mechanistic Aspects of [3+2] Cycloaddition Reaction of Trifluoroacetonitrile with Diarylnitrilimines in Light of Molecular Electron Density Theory Quantum Chemical Study DOI Creative Commons
Agnieszka Łapczuk-Krygier, Mar Ríos‐Gutiérrez

Molecules, Год журнала: 2024, Номер 30(1), С. 85 - 85

Опубликована: Дек. 29, 2024

In this study, we investigated the [3+2] cycloaddition reaction of CF3CN (TFAN) with nitrilimine (NI) to produce 1,2,4-triazole and compared resulting isomers. We determined preferred pathway by examining electrophilic nucleophilic properties substrates, performing thermodynamic calculations for individual pathways, comparing them experimental results.

Язык: Английский

Процитировано

0