Mitochondria and its epigenetic dynamics: Insight into synaptic regulation and synaptopathies
Functional & Integrative Genomics,
Год журнала:
2025,
Номер
25(1)
Опубликована: Янв. 23, 2025
Язык: Английский
Compound B vitamins mitigate post-traumatic stress disorder-like behaviors induced by single prolonged stress in rats by inhibiting hippocampal mitochondrial DNA methylation
Journal of Neurorestoratology,
Год журнала:
2025,
Номер
unknown, С. 100187 - 100187
Опубликована: Янв. 1, 2025
Язык: Английский
Association of single and combined effects of blood heavy metals with cognitive function in older adults of the United States: A cross-sectional study
Na Wang,
Liang Guo,
Menglian Shi
и другие.
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
Abstract
Background
Heavy
metal
exposure
has
been
associated
with
various
diseases.
The
purpose
of
this
study
was
to
determine
the
single
and
combined
effects
between
blood
heavy
metals
cognitive
function
in
older
adults.
Methods
This
observational
utilizes
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2011
2014
involved
1460
participants
aged
≥
60
years.
concentrations
lead
(Pb),
cadmium
(Cd),
mercury
(Hg),
selenium
(Se),
manganese
(Mn)
were
measured
using
inductively
coupled
plasma
mass
spectrometry
(ICP-MS).
Cognitive
assessed
immediate
Recall
test
(IRT),
delayed
recall
(DRT),
animal
fluency
(AFT),
digit
symbol
substitution
(DSST).
Linear
regression,
restricted
cubic
spline
(RCS),
subgroup
analyses
used
assess
relationship
function.
Results
Multiple
linear
regression
analysis
showed
a
negative
correlation
Cd
comprehensive
scores
(
β=-2.698,
95%
CI:
-4.842,
-0.554).
Blood
Se
levels
positively
correlated
(
β
=
0.049,
0.022,
0.076)
all
four
domains.
RCS
that
dose-response
association
appeared
be
(
P-nonlinear
0.566),
while
exhibited
parabolic
shape
tilted
left
0.013).
Conclusions
A
high
concentration
is
strongly
decline.
However,
protective
effect
on
plateaus
after
reaching
certain
concentration.
These
findings
may
have
significance
for
development
interventions
aimed
at
alleviating
impairment.
Язык: Английский
Mitochondria and its Epigenetic Dynamics: Insight into Synaptic Regulation and Synaptopathies
Опубликована: Янв. 1, 2024
Язык: Английский