Grape seeds: nutritional value, health advantages, and industrial applications
Food & medicine homology.,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Concord grape (Vitis labrusca ‘Concord’) pomace extract impacts dextran sulfate sodium-induced inflammation in ovo (Gallus gallus)
Journal of Functional Foods,
Год журнала:
2025,
Номер
129, С. 106840 - 106840
Опубликована: Апрель 28, 2025
Язык: Английский
Enhancing colonic health with encapsulated grape seed anthocyanins: Oral capsule for Colon-targeted delivery
Food Chemistry,
Год журнала:
2024,
Номер
469, С. 142544 - 142544
Опубликована: Дек. 18, 2024
Язык: Английский
Antioxidant Therapy in Inflammatory Bowel Diseases: How Far Have We Come and How Close Are We?
Antioxidants,
Год журнала:
2024,
Номер
13(11), С. 1369 - 1369
Опубликована: Ноя. 8, 2024
Inflammatory
bowel
diseases
(IBD)
pose
a
growing
public
health
challenge
with
unclear
etiology
and
limited
efficacy
of
traditional
pharmacological
treatments.
Alternative
therapies,
particularly
antioxidants,
have
gained
scientific
interest.
This
systematic
review
analyzed
studies
from
MEDLINE,
Cochrane,
Web
Science,
EMBASE,
Scopus
using
keywords
like
“Inflammatory
Bowel
Diseases”
“Antioxidants.”
Initially,
925
publications
were
identified,
after
applying
inclusion/exclusion
criteria—covering
July
2015
to
June
2024
murine
models
or
clinical
trials
in
humans
evaluating
natural
synthetic
substances
affecting
oxidative
stress
markers—368
articles
included.
comprised
344
animal
24
human
studies.
The
most
investigated
antioxidants
polyphenols
active
compounds
medicinal
plants
(n
=
242;
70.3%).
found
strong
link
between
inflammation
IBD,
especially
on
nuclear
factor
kappa
B
erythroid
2-related
2
pathways.
However,
it
remains
whether
occurs
first
IBD.
Lipid
peroxidation
was
the
studied
damage,
followed
by
DNA
damage.
Protein
damage
rarely
investigated.
relationship
gut
microbiota
examined
103
Human
markers
scarce,
reflecting
major
research
gap
IBD
treatment.
PROSPERO
registration:
CDR42022335357
CRD42022304540.
Язык: Английский
Integrating Network Pharmacology and Metabolomics to Explore the Potential Mechanism of β‐Sitosterol Against Hyperuricemia Nephropathy
Journal of Food Biochemistry,
Год журнала:
2024,
Номер
2024(1)
Опубликована: Янв. 1, 2024
Background:
Renal
involvement
resulting
from
hyperuricemia,
known
as
hyperuricemia
nephropathy
(HN),
is
characterized
by
chronic
tubulointerstitial
inflammation
caused
extensive
urate
crystal
deposition.
Managing
this
condition
requires
straightforward
preventive
or
therapeutic
interventions,
primarily
through
dietary
measures.
Methods:
In
study,
the
mouse
model
of
HN
was
established
using
yeast
extract
combined
with
potassium
oxonate.
The
effect
and
potential
mechanism
β‐sitosterol
in
treating
were
investigated
biochemical
indexes,
pathological
changes,
untargeted
metabolomics,
network
pharmacology.
Results:
β‐Sitosterol
reduced
levels
four
biomarkers
HN:
uric
acid
(UA),
creatinine
(CRE),
blood
urea
nitrogen
(BUN),
xanthine
oxidase
(XOD).
It
also
mitigated
inflammatory
injury
renal
tissues
reversed
abnormal
expression
key
transporter
proteins:
glucose
protein
9
(GLUT9),
organic
anion
1
(OAT1),
ATP‐binding
cassette
G2
(ABCG2),
(URAT1).
To
explore
HN,
study
employed
pharmacology
metabolomics
to
analyze
27
intersecting
gene
targets
14
differential
metabolites.
findings
indicated
that
glutathione
(GSH)
metabolism
might
be
a
crucial
pathway.
Treatment
increased
GSH
well
activity
6‐phosphogluconate
dehydrogenase
(G6PDH)
mice,
thereby
effectively
modulating
metabolism.
This
proposes
novel
strategy
for
providing
promising
approach
addressing
condition.
Язык: Английский
Dietary supplementation of grape seed proanthocyanidins improves growth performance, carcass traits, and meat quality in growing-finishing pigs
Animal nutrition,
Год журнала:
2024,
Номер
20, С. 200 - 210
Опубликована: Ноя. 20, 2024
Grape
seed
proanthocyanidin
(GSP)
is
a
type
of
plant
polyphenol
with
wide
variety
biological
activities,
such
as
antioxidant
properties.
This
study
investigated
the
effects
GSP
supplementation
on
growth
performance
and
meat
quality
in
growing-finishing
pigs.
A
total
180
pigs
(with
an
initial
average
body
weight
30.37
±
0.66
kg)
were
randomly
assigned
to
five
treatments:
control
diet
or
supplemented
at
15,
30,
60,
120
mg/kg.
Each
treatment
group
comprised
six
replicate
pens
(6
per
pen).
Results
showed
that
linearly
increased
daily
gain
(P
=
0.048)
quadratically
decreased
feed
intake
ratio
0.049)
lowest
values
30
60
mg/kg
GSP.
Serum
concentrations
immunoglobulins
(Ig)
(IgA,
IgG,
IgM),
antioxidative
capacity,
catalase,
superoxide
dismutase
elevated
peak
levels
<
0.05).
glutathione
peroxidase
malondialdehyde
0.05),
trough
GSP,
respectively.
The
also
improved
dressing
percentage
muscle
redness
(a∗45
min)
optimal
Additionally,
reduced
yellowness
(b∗24
h)
shear
force
expression
level
myosin
heavy
chain
I
was
maximum
0.015).
Furthermore,
fatty
acid
synthase,
phosphoenolpyruvate
carboxykinase
(PEPCK),
glucokinase
0.05)
upregulated
hepatic
hormone-sensitive
triglyceride
lipase
PEPCK
These
results
suggest
enhances
carcass
characteristics
pigs,
potentially
through
modified
fiber
distribution,
altered
glucose-lipid
metabolism
liver.
Язык: Английский
Dietary grapeseed oil nano-emulsion improves blood health, organ histology, antioxidant status, immune-ability, and reduces inflammation in young fattening rabbits exposed to thermal stress
Nada Attia,
Usama M. Abdel Monem,
Bakry A. Khalil
и другие.
Annals of Animal Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 27, 2024
Abstract
Heat
stress
(HS)
represents
a
major
environmental
impact
on
rabbits’
health,
welfare,
and
production.
Grape
seed
oil
(GSO)
has
improved
health
growth.
However,
the
mechanism
by
which
they
mitigate
negative
effects
of
HS
in
growing
rabbits
is
still
under
debate.
This
study
explored
protective
role
dietary
grape
nanoemulsion
(GON)
against
blood
changes,
immune
dysfunction,
organ
histological
damage,
oxidative
stress,
inflammation
triggered
rabbits.
A
total
120
(5
weeks
age
average
weight
657.32
g)
were
divided
into
4
groups.
The
administered
with
different
doses
GON:
0
(HS,
basal
diet),
0.5
(GON0.5),
1
(GON1.0),
1.5
(GON1.5)
mL/kg
diet
for
8
natural
heat
conditions.
results
indicated
that
GON1.0
GON1.5
groups
exhibited
higher
body
values
gains
than
other
(P<0.05),
showing
linear
relationship
GON
levels.
quadratic
was
observed
between
FCR
GON,
optimal
dose
being
0.7mL/kg
diet.
group
had
red
cell
(p<0.05),
while
all
significantly
reduced
leukocyte
counts
compared
to
(p<0.001)
manner.
enhanced
protein
fractions
regression
analysis.
Additionally,
ALT,
AST,
lipid
profile,
uric
acid,
LDH,
GGT,
direct
bilirubin
decreased
fed
(p<0.05)
Enriching
diets
(1
or
mL)
antioxidant
status
(SOD
GPx)
immunity
(IgG
IgM)
It
also
resulted
decrease
(MDA
PC)
(IL-6,
lysosome
activity,
IFN‐γ)
levels
(p<0.001).
There
increase
IL-10
nitric
oxide
increasing
0.86
0.9
administration
maintained
architecture
(liver,
spleen,
intestines)
expression
iNOS
liver
tissues
induced
HS.
Collectively,
diet)
an
effective
feed
additive
improving
growth
stressed
supporting
functions
reducing
pathways
Язык: Английский