Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Окт. 14, 2024
Iron,
an
essential
mineral
in
the
body,
is
involved
numerous
physiological
processes,
making
maintenance
of
iron
homeostasis
crucial
for
overall
health.
Both
overload
and
deficiency
can
cause
various
disorders
human
diseases.
Ferroptosis,
a
form
cell
death
dependent
on
iron,
characterized
by
extensive
peroxidation
lipids.
Unlike
other
kinds
classical
unprogrammed
death,
ferroptosis
primarily
linked
to
disruptions
metabolism,
lipid
peroxidation,
antioxidant
system
imbalance.
Ferroptosis
regulated
through
transcription,
translation,
post-translational
modifications,
which
affect
cellular
sensitivity
ferroptosis.
Over
past
decade
or
so,
diseases
have
been
as
part
their
etiology,
including
cancers,
metabolic
disorders,
autoimmune
diseases,
central
nervous
cardiovascular
musculoskeletal
Ferroptosis-related
proteins
become
attractive
targets
many
major
that
are
currently
incurable,
some
regulators
shown
therapeutic
effects
clinical
trials
although
further
validation
potential
needed.
Therefore,
in-depth
analysis
its
molecular
mechanisms
may
offer
additional
strategies
prevention
treatment.
In
this
review,
we
discuss
significance
contribution
etiology
development
along
with
evidence
supporting
targeting
approach.
Importantly,
evaluate
recent
promising
interventions,
providing
guidance
future
targeted
treatment
therapies
against
Язык: Английский
The Role and Mechanisms of Ubiquitin-Proteasome System-Mediated Ferroptosis in Neurological Disorders
Neuroscience Bulletin,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Язык: Английский
Exploring the Nexus: How Ferroptosis, Microglia, and Neuroinflammation Converge in Ischemic Stroke Pathogenesis
Molecular Neurobiology,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 10, 2025
Язык: Английский
Research progress of ferroptosis pathway and its related molecular ubiquitination modification in liver cancer
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Март 21, 2025
As
a
new
type
of
programmed
cell
death,
ferroptosis
is
characterized
by
iron
metabolism
disorder
and
reactive
oxygen
species
(ROS)
accumulation,
involved
in
regulating
the
occurrence
development
cancer
cells.
Especially
field
liver
treatment,
shows
great
potential
because
it
can
induce
tumor
death.
Ubiquitination
process
protein
post-translational
modification,
which
affect
stability
proteins
regulate
progress
ferroptosis.
This
article
reviews
research
ubiquitination
modification
molecules
related
to
pathway
regulation
cancer,
providing
strategy
for
treatment
cancer.
Язык: Английский
Melatonin attenuates spinal cord injury by regulating ferroptosis through the Nrf2/HO-1/GPX4 pathway
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 31, 2025
Abstract
Spinal
cord
injury
(SCI)
is
one
of
the
most
devastating
and
catastrophic
types
injury,
with
high
rates
mortality
disability.
Ferroptosis
has
become
target
many
major
incurable
human
diseases.
By
inhibiting
ferroptosis,
melatonin
(MT)
can
reduce
damage
in
various
organs,
but
protective
effect
MT
on
SCI
not
been
reported
yet.
The
modified
Ellen's
method
was
used
to
establish
an
rat
model.
spinal
neurons
recovery
motor
function
were
observed.
In
vitro
experiments,
oxygen-glucose
deprivation/reoxygenation
(OGD/R)
model
established
by
using
mouse
hippocampal
neuron
(HT22)
cells
simulate
ischemia-reperfusion
injury.
A
ferroptosis
directly
induced
Erastin
also
used.
nuclear
factor
erythroid
2-related
2
(Nrf2)
inhibitor
ML
385
further
detect
mechanism
through
which
inhibits
protects
neuronal
cells.
Our
study
demonstrates
that
rats,
promote
behavior
injured
tissue
after
SCI.
Under
electron
microscope,
inhibited
rescued
damaged
mitochondria,
partially
restored
mitochondrial
structure.
ML385,
Nrf2
inhibitor,
reversed
effects
MT.
Overall,
may
alleviate
early
activating
Nrf2/heme
oxygenase-1(HO-1)/glutathione
peroxidase
4
(GPX
4)
pathway.
Язык: Английский
The AKR1C1–CYP1B1–cAMP signaling axis controls tumorigenicity and ferroptosis susceptibility of extrahepatic cholangiocarcinoma
Cell Death and Differentiation,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 30, 2024
Язык: Английский
The role of ACSL4 in stroke: mechanisms and potential therapeutic target
Molecular and Cellular Biochemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 4, 2024
Stroke,
as
a
neurological
disorder
with
poor
overall
prognosis,
has
long
plagued
the
patients.
Current
stroke
therapy
lacks
effective
treatments.
Ferroptosis
emerged
prominent
subject
of
discourse
across
various
maladies
in
recent
years.
As
an
emerging
therapeutic
target,
notwithstanding
its
initial
identification
tumor
cells
associated
brain
diseases,
it
lately
been
recognized
pivotal
factor
pathological
progression
stroke.
Acyl-CoA
synthetase
long-chain
family
member
4
(ACSL4)
is
potential
target
and
biomarker
catalytic
unsaturated
fatty
acids
mediating
ferroptosis
Specifically,
upregulation
ACSL4
leads
to
heightened
accumulation
lipid
peroxidation
products
reactive
oxygen
species
(ROS),
thereby
exacerbating
neuronal
cells.
present
tissues
involved
multiple
pathways
ferroptosis.
At
present,
pharmacological
mechanisms
targeting
inhibit
have
found
many
drugs,
but
molecular
are
still
exploratory
stage.
This
paper
introduces
physiopathological
mechanism
current
status
research
crosstalk
epigenetics,
summarizes
application
modern
pharmacology
research,
discusses
value
field
Язык: Английский
An update on the role of ferroptosis in ischemic stroke: from molecular pathways to Neuroprotection
Expert Opinion on Therapeutic Targets,
Год журнала:
2024,
Номер
unknown, С. 1 - 27
Опубликована: Дек. 23, 2024
Introduction
Ischemic
stroke
(IS),
a
major
cause
of
mortality
and
disability
worldwide,
remains
significant
healthcare
challenge
due
to
limited
therapeutic
options.
Ferroptosis,
distinct
iron-dependent
form
regulated
cell
death
characterized
by
lipid
peroxidation
oxidative
stress,
has
emerged
as
crucial
mechanism
in
IS
pathophysiology.
This
review
explores
the
role
ferroptosis
its
potential
for
driving
innovative
strategies.
Язык: Английский
Metabolic Side Effects from Antipsychotic Treatment with Clozapine Linked to Aryl Hydrocarbon Receptor (AhR) Activation
Biomedicines,
Год журнала:
2024,
Номер
12(10), С. 2294 - 2294
Опубликована: Окт. 10, 2024
Metabolic
syndrome
(MetS)
is
the
most
common
adverse
drug
reaction
from
psychiatric
pharmacotherapy.
Neuroreceptor
blockade
by
antipsychotic
clozapine
induces
MetS
in
about
30%
of
patients.
Similar
to
insulin
resistance,
impedes
Akt
kinase
activation,
leading
intracellular
glucose
and
glutathione
depletion.
Additional
cystine
shortage
triggers
tryptophan
degradation
kynurenine,
which
a
well-known
AhR
ligand.
Ligand-bound
downregulates
iron
pool,
thereby
increasing
risk
mitochondrial
dysfunction.
Scavenging
stabilizes
transcription
factor
HIF-1,
shifts
metabolism
toward
transient
glycolysis.
Furthermore,
inhibits
AMPK
obesity
liver
steatosis.
Increasing
uptake
activation
prevents
dyslipidemia
damage
and,
therefore,
reduces
MetS.
In
line
with
vitro
results,
feeding
experiments
rats
revealed
disturbed
glucose-/lipid-/iron-metabolism
treatment
hyperglycemia
hepatic
deposits
female
steatosis
anemia
male
animals.
Decreased
energy
expenditure
seems
be
cause
fast
weight
gain
first
weeks
treatment.
patients,
this
due
neuroleptic
correlates
an
improvement
psychotic
syndromes
can
even
used
anticipate
therapeutic
effect
Язык: Английский
The ameliorative effects of melatonin against BDE-47-induced hippocampal neuronal ferroptosis and cognitive dysfunction through Nrf2-Chaperone-mediated autophagy of ACSL4 degradation
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
290, С. 117542 - 117542
Опубликована: Дек. 18, 2024
Язык: Английский