Separable Microneedle Patch Integrated with the Dictamnine-Loaded Copper MOF Nanozyme for Atopic Dermatitis Treatment
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
Atopic
dermatitis
(AD)
is
a
chronic
inflammatory
skin
disorder
marked
by
thickening,
severe
pruritus,
lesions,
and
emotional
disturbances,
including
anxiety
depression-like
behavior.
Current
treatments
primarily
rely
on
localized
therapies,
which
can
lead
to
adverse
effects
such
as
hyperglycemia
Cushing's
syndrome
with
repeated
use.
To
address
these
issues,
we
developed
hyaluronic
acid-based
separable
microneedle
patch
(Dic@pCu-HA
MN),
integrating
polydopamine-coordinated
copper-based
metal-organic
frameworks
(pCu-MOFs)
the
anti-inflammatory
agent
dictamnine
(Dic),
for
synergistic
management
of
AD
its
neuropsychiatric
comorbidities.
pCu-MOFs
exhibited
dual
functionality
nanocargo
hydrophobic
Dic
(encapsulation
efficiency:
84.62
±
2.14%)
multienzyme
mimics
that
efficiently
scavenge
reactive
oxygen
species
(ROS)
(superoxide
radical
scavenging:
63.85
0.34%).
In
vitro
release
studies
demonstrated
ROS-responsive
86.80
4.83%
over
48
h
under
pathology-mimicking
conditions.
1-Chloro-2,4-dinitrochlorobenzene
(DNCB)-induced
mouse
model,
Dic@pCu-HA
MN
significantly
reduced
oxidative
stress
(8-OHdG:
85.1
7.0%
decrease),
suppressed
pro-inflammatory
cytokines
(IL-4:
70.0
7.8%
decrease
vs
control),
restored
barrier
integrity.
By
modulating
HPA
axis,
system
attenuated
neuroinflammation
alleviated
itching
(scratching
frequency:
40.1
41.3%
reduction)
behavior
(time
in
bright
box:
96.6
156.2%
increase).
This
combined
therapeutic
approach
not
only
offers
comprehensive
strategy
but
also
provides
potential
benefits
addressing
disorders
their
sequelae.
Язык: Английский
Digital identification and adulteration analysis of Codonopsis Radix and Stellariae Radix based on the “digital identity” of chemical compositions
Frontiers in Chemistry,
Год журнала:
2024,
Номер
12
Опубликована: Ноя. 7, 2024
Introduction
Under
the
background
of
digitalization
traditional
Chinese
medicine
(TCM),
this
study
aimed
to
realize
digital
identification
and
adulteration
analysis
Codonopsis
Radix
(CR)
Stellariae
(SR)
based
on
chemical
analysis.
Methods
This
combined
concepts
conducted
a
CR
SR
from
different
batches
UHPLC-QTOF-MS
E
.
Furthermore,
shared
ions
were
extracted
as
their
“ion
characterization”
after
quantization.
Then,
data
matrices
unique
relative
screened
out,
top-N
outputted
“digital
identities”
SR,
sorted
by
ionic
strength.
Finally,
above
used
benchmarks
for
matching
positive
samples
market
provide
feedback
credibility
(MC)
Results
The
results
showed
that
CR,
can
be
realized
at
individual
level
TCM
efficiently
accurately,
even
if
3%
in
mixed
still
identified
accurately.
Moreover,
1
12
was
an
adulterated
sample.
Conclusion
It
proved
two
herbs
quickly
through
compositions.
has
important
reference
significance
developing
identity”
compositions,
which
beneficial
construction
quality
control
SR.
Язык: Английский
The biological roles of exosome-encapsulated traditional Chinese medicine monomers in neuronal disorders
Journal of Pharmaceutical Analysis,
Год журнала:
2024,
Номер
unknown, С. 101131 - 101131
Опубликована: Окт. 1, 2024
Язык: Английский
Macrophages in inflammatory skin diseases and skin tumors
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 5, 2024
Macrophages,
as
specialized,
long-lasting
phagocytic
cells
of
the
innate
immune
system,
have
garnered
increasing
attention
due
to
their
wide
distribution
and
various
functions.
The
skin,
being
largest
organ
in
human
body,
presents
an
intriguing
landscape
for
macrophage
research,
particularly
regarding
roles
inflammatory
skin
diseases
tumors.
In
this
review,
we
compile
latest
research
on
macrophages
conditions
such
atopic
dermatitis,
psoriasis,
systemic
sclerosis,
lupus
erythematosus,
rosacea,
bullous
pemphigoid,
melanoma
cutaneous
T-cell
lymphoma.
We
aim
contribute
illustrating
pathogenesis
potential
new
therapies
tumors
from
perspective
macrophages.
Язык: Английский