Protective Effects of Syringic Acid Against Oxidative Damage, Apoptosis, Autophagy, Inflammation, Testicular Histopathologic Disorders, and Impaired Sperm Quality in the Testicular Tissue of Rats Induced by Mercuric Chloride
Environmental Toxicology,
Год журнала:
2024,
Номер
39(10), С. 4803 - 4814
Опубликована: Авг. 3, 2024
Mercury
(Hg)
is
one
of
the
most
toxic
heavy
metals
that
damage
testicular
tissue.
chloride
(HgCl
Язык: Английский
Ameliorative effects of sinapic acid against vancomycin-induced testicular oxidative damage, apoptosis, inflammation, testicular histopathologic disorders and decreased epididymal sperm quality
Reproductive Toxicology,
Год журнала:
2024,
Номер
129, С. 108666 - 108666
Опубликована: Июль 25, 2024
Язык: Английский
Chrysin Counteracts Sodium Hydroxide-Induced Alkali Esophageal Burn by Regulating Beclin-1/HO-1/NQO1, PERK/IRE1-α/ATF-6, Oxidative Stress, Inflammation, Apoptosis Signaling Pathways and Ki-67, EGF Expressions in Rats
Bratislavské lekárske listy/Bratislava medical journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 14, 2025
Abstract
Aim
Alkali-esophageal
burn
due
to
ingestion
of
corrosive
substances
is
an
important
clinical
entity
that
can
be
seen
in
all
age
groups,
especially
children.
Chrysin
a
natural
flavonoid
compound
with
wide
range
biological
activities,
including
antioxidant,
anti-inflammatory,
antiapoptotic,
and
anticancer
effects.
This
study
aimed
ascertain
the
preventive
efficacy
chrysin
treatment
alkali-esophageal
burns.
Materials
Methods
Rats
were
administered
0.2
ml
25%
NaOH
orally
CHR
at
25
50
mg/kg
intraperitoneally
for
four
days.
The
levels
oxidative
stress,
ER
inflammation,
damage,
apoptotic
autophagic
cell
death
esophageal
tissues
analyzed
using
biochemical
molecular
methods.
Additionally,
tissue
structure
function
examined
histological
Results
alleviated
NaOH-induced
increased
stress
by
decreasing
MDA
increasing
antioxidants.
inflammation
damage
inhibiting
NF-κB
signaling
pathway.
decreased
Caspase-3,
Bax
antiapoptotic
Bcl-2.
Moreover,
reduced
damage.
facilitated
restoration
impaired
structural
integrity
Ki-67
EGF
levels,
contributing
healing
process.
Conclusion
exhibited
anti-autophagic,
anti-oxidant
properties
alkali
burns,
as
well
effect
on
reducing
injury.
facilitates
maintains
integrity.
Graphical
abstract
Язык: Английский
Lead systemic toxicity: a persistent problem for health.
Toxicology,
Год журнала:
2025,
Номер
515, С. 154163 - 154163
Опубликована: Апрель 24, 2025
Lead
(Pb)
has
been
used
by
humans
since
prehistoric
times
to
make
tools
due
its
malleability
and
durability.
The
Roman
Empire,
the
Industrial
Revolution,
introduction
of
Pb
in
gasoline
during
1920s
contributed
increased
environmental
concentrations.
toxicity
led
removal
from
after
several
decades.
However,
continues
be
emitted
various
anthropogenic
sources,
including
but
not
limited
batteries,
mining,
foundries,
smelting,
e-waste
recycling,
painting.
remains
an
concern,
as
no
established
safe
concentration
for
human
health
identified.
Children
are
more
susceptible
absorption
poisoning
Pb.
Occupational
exposure
poses
a
significant
risk
workers
individuals
living
near
lead
industries.
primary
routes
inhalation
ingestion,
bioaccumulation
biomagnification
through
food
chain
major
sources
exposure.
This
review
aims
provide
overview
systemic
Pb,
effects
on
lungs,
blood,
liver,
kidneys,
nervous,
cardiovascular,
reproductive
systems.
Since
is
classified
probable
carcinogen
humans,
article
also
addresses
genotoxicity
cancer
risk.
Furthermore,
it
reviews
most
researched
mechanisms
toxicity,
calcium
mimicry,
oxidative
stress,
inflammation,
along
with
other
less-studied
mechanisms.
Nevertheless,
authors
emphasize
importance
exploring
less
examined
cells,
tissues,
deepen
understanding
at
concentrations,
particularly
cases
chronic
low-level
exposure,
develop
better
prevention
treatment
strategies
poisoning.
Язык: Английский
Kurşun Kaynaklı Oluşan Dalak Toksisitesine Karşı Sinapik Asitin Etkilerinin İncelenmesi
Deleted Journal,
Год журнала:
2024,
Номер
4(2), С. 72 - 77
Опубликована: Сен. 7, 2024
Bu
çalışma,
fenolik
asit
içeren
doğal
bitkisel
bileşik
olan
sinapik
asidin
(SA),
erkek
ratlarda
kurşun
(Pb)
kaynaklı
dalak
toksisitesine
karşı
etkilerini
incelemeyi
amaçladı.
Dalak
toksisitesi,
ratların
7
gün
boyunca
sadece
Pb
ya
da
ile
kombinasyon
halinde
SA’nın
oral
tedavisini
takiben
değerlendirildi.
Doku
malondialdehit
(MDA)
seviyeleri,
glutatyon
(GSH)
peroksidaz
(GPx),
süperoksit
dismutaz
(SOD)
ve
katalaz
(KAT)
aktiviteleri
biyokimyasal
olarak
belirlendi.
dokusunda
uygulanan
grupta
MDA
düzeyi
artarken,
GSH
seviyeleri
GPx,
SOD,
KAT
azaldı.
birlikte
uygulanmasının
düzeyini
azalttığı,
aktivitelerini
arttırdığı
gözlemlendi.
Ayrıca
Pb'nin
NF-κB,
TNF-α,
IL-1β,
COX-2,
Beklin-1
kaspaz-3
seviyelerini
önemli
ölçüde
artırdığını
gösterdi.
Kontrol
grubuyla
karşılaştırıldığında
ise,
SA
tedavisinin
azalttığı
Sonuç
bu
çalışmada
SA'nın
hasarına
koruyucu
özelliğe
sahip
olduğu
Carvacrol Ameliorates Cisplatin-Induced Cardiotoxicity By Regulating Notch/Hes1 Signaling Pathway, Oxidative Stress and Cell Death In Rat Cardiac Tissue
Türk doğa ve fen dergisi :/Türk doğa ve fen dergisi,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 8, 2024
Cisplatin
is
one
of
the
most
active
cytotoxic
agents
used
mainly
in
treatment
solid
tumors.
High
doses
and
long-term
use
are
known
to
cause
cardiotoxicity.
In
recent
years,
antiapoptotic
antioxidant
effects
Carvacrol
cardiovascular
diseases
have
attracted
attention.
this
study,
on
Cisplatin-induced
cardiotoxicity
a
rat
model
were
investigated
using
biochemical
histological
methods.
Twenty-eight
rats
divided
into
4
groups:
1.
Control
group,
2.
3.
4.
+
group.
The
expression
enzymes,
proinflammatory
cytokines,
apoptotic,
autophagic
proteins
was
examined
heart
tissue
obtained
from
sacrificed
after
last
drug
administration.
Additionally,
evaluated
histopathologically.
has
been
observed
oxidative
stress
inflammatory
damage
animal
tissue.
administration
significantly
increased
enzyme
(superoxide
dismutase
glutathione
peroxidase)
activities
while
suppressing
markers
(NF-κB,
TNF-α,
IL-1β).
induced
apoptotic
(caspase-3,
Bax,
Bcl-2)
(Beclin-1,
LC3A,
LC3B)
markers.
It
determined
that
carvacrol
can
protect
tissues
destructive
cisplatin
by
exerting
anti-apoptotic
anti-autophagic
effects.
levels
Notch1
Hes1,
which
decreased
administration,
upregulated
Carvacrol.
H&E
staining
results
showed
preserved
myocardial
integrity.
conclusion,
cardioprotective
effect
against
cisplatin-induced
Язык: Английский
Investigation of the Effects of Acetylsalicylic Acid Administration at Different Doses on Behavioral Disorders in Rats
Türk doğa ve fen dergisi :/Türk doğa ve fen dergisi,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 30, 2024
Aspirin
is
one
of
the
most
widely
used
non-steroidal
anti-inflammatory
drugs
worldwide.
Neurodegenerative
diseases
adversely
affect
central
nervous
system,
leading
to
cognitive
decline.
has
different
pharmacological
activities
at
doses.
Therefore,
this
study
aimed
determine
effects
acetylsalicylic
acid
(ASA),
active
ingredient
aspirin,
administered
doses
on
parameters
that
play
a
role
in
function
using
molecular
and
histological
methods
behavioral
tests.
For
purpose,
28
Wistar
rats
were
divided
into
4
groups.
Control,
ASA-low
dose
(1mg/kg),
ASA-moderate
(10mg/kg)
ASA-high
(100mg/kg).
ASA
was
intragastrically
as
single
dose,
an
open
field
test
performed
3
hours
later.
Subsequently,
hippocampus
tissues
obtained,
tissue
structure
analyzed
by
analyzing
involved
antioxidant
capacity,
inflammation,
apoptosis,
memory.
ASA,
especially
moderate
doses,
increased
capacity
partially
reduced
inflammation
apoptotic
damage.
At
high
opposite
effect
observed,
damage
levels.
Similar
detected
examination.
Although
there
no
structural
defects
low
or
observed
difference
findings
between
groups,
time
spent
center,
distance
traveled,
speed
slightly
higher
moderate-dose
group.
In
conclusion,
may
contribute
improvement
However,
cause
impairment.
Язык: Английский