Luteolin Modulate Endoplasmic Reticulum Stress by Targeting SIRT1 to Ameliorate DSS‐Induced Ulcerative Colitis in Mice
The FASEB Journal,
Год журнала:
2025,
Номер
39(7)
Опубликована: Апрель 10, 2025
ABSTRACT
Ulcerative
colitis
(UC)
is
a
recurrent,
chronic
disease
whose
main
symptoms
include
weight
loss,
diarrhea,
and
blood
in
the
stool.
In
recent
years,
incidence
of
UC
has
been
increasing
year
by
year,
which
seriously
affects
daily
life
patients.
Luteolin
(Lut),
as
flavonoid,
widely
found
variety
vegetables
fruits
shown
to
have
pharmacological
activities.
This
work
investigated
effects
Lut
on
dextrose
sodium
sulfate
(DSS)‐induced
ulcerative
mice,
with
special
focus
role
endoplasmic
reticulum
(ER)
stress
this.
The
outcomes
demonstrated
that
symptoms,
including
phenotype,
elevated
inflammatory
factor
levels,
intestinal
barrier
damage,
gut
microbiota
disruption,
were
considerably
alleviated
model
mice
treated
luteolin.
Also,
ER
apoptosis
mice.
We
then
explored
induced
thapsigargin
(TG)
tunicamycin
(TM)
HT29
cells
vitro.
It
was
treatment
inhibited
TM/TG‐induced
apoptosis.
However,
these
inhibitory
attenuated
SIRT1
silencing
TM‐treated
cells.
conclusion,
our
results
suggest
supplementation
mouse
improves
provides
theoretical
basis
for
further
application
prevention
inflammation‐related
diseases
humans.
Язык: Английский
Fluorinated Sulfonamide-Flavonoid Derivatives as Novel Keap1-Nrf2 Inhibitors: Potent Induction of Cytoprotective Gene HO-1 In Vivo
European Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
291, С. 117650 - 117650
Опубликована: Апрель 17, 2025
Язык: Английский
Inhibitory Effect of Luteolin on Spike S1 Glycoprotein-Induced Inflammation in THP-1 Cells via the ER Stress-Inducing Calcium/CHOP/MAPK Pathway
Pharmaceuticals,
Год журнала:
2024,
Номер
17(10), С. 1402 - 1402
Опубликована: Окт. 20, 2024
The
global
SARS-CoV-2
outbreak
has
escalated
into
a
critical
public
health
emergency,
with
the
spike
glycoprotein
S1
subunit
of
(spike-S1)
linked
to
inflammation
in
lung
tissue
and
immune
cells.
Luteolin,
flavone
anti-inflammatory
properties,
shows
promise,
but
research
on
its
effectiveness
against
long-COVID-related
protein-induced
responses
remains
limited.
This
study
aims
elucidate
underlying
mechanisms
THP-1
cells
induced
by
spike-S1.
Additionally,
it
seeks
assess
potential
luteolin
mitigating
inflammatory
spike-S1
macrophage
model.
Язык: Английский
Effect of natural products on host cell autophagy induced by Influenza A virus infection
Xiaopan Liu,
Qingsen Wang
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Сен. 30, 2024
Influenza
A
virus
(IAV)
can
cause
seasonal
epidemics
and
global
pandemics,
posing
serious
threats
to
public
health,
making
a
deeper
understanding
of
its
biological
characteristics
effective
countermeasure
strategies
essential.
Autophagy
not
only
maintains
cellular
homeostasis
but
also
plays
an
important
role
in
host
defense
against
IAV
infection.
However,
the
relationship
between
autophagy
is
complex,
antiviral
drugs
are
yet
available.
Natural
products
have
shown
excellent
potential
disease
control
due
their
diversity
multi-targeting.
This
review
focuses
on
discusses
targeting
autophagic
pathways
for
development
new
therapies.
Particularly,
use
plant
extracts
as
modulators
has
garnered
attention
non-toxic
nature
cost-effectiveness,
which
provides
strong
support
future
that
help
inhibit
viral
infections
slow
down
progression.
Язык: Английский