SARS-CoV-2 placentitis, stillbirth, and maternal COVID-19 vaccination: clinical–pathologic correlations

American Journal of Obstetrics and Gynecology, Год журнала: 2022, Номер 228(3), С. 261 - 269

Опубликована: Окт. 12, 2022

Stillbirth is a recognized complication of COVID-19 in pregnant women that has recently been demonstrated to be caused by SARS-CoV-2 infection the placenta. Multiple global studies have found placental pathology present cases stillbirth consists combination concurrent destructive findings include increased fibrin deposition typically reaches level massive perivillous deposition, chronic histiocytic intervillositis, and trophoblast necrosis. These 3 pathologic lesions, collectively termed placentitis, can cause severe diffuse parenchymal destruction affect >75% placenta, effectively rendering it incapable performing its function oxygenating fetus leading neonatal death via malperfusion insufficiency. Placental occur absence demonstrable fetal infection. Development placentitis complex process may both an infectious immunologic basis. An important observation all reported causing death, mothers were unvaccinated. likely result episode viremia at some time during pregnancy. This article discusses clinical aspects relationship between maternal vaccination, perinatal death.

Язык: Английский

---

Systematic review and synthesis of stillbirths and late miscarriages following SARS-CoV-2 infections

American Journal of Obstetrics and Gynecology, Год журнала: 2023, Номер 229(2), С. 118 - 128

Опубликована: Янв. 25, 2023

Язык: Английский

---

SARS-CoV-2 Transplacental Transmission: A Rare Occurrence? An Overview of the Protective Role of the Placenta

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(5), С. 4550 - 4550

Опубликована: Фев. 25, 2023

The outbreak of the coronavirus disease 2019 (COVID-19) pandemic, caused by novel severe acute respiratory syndrome 2 (SARS-CoV-2), has resulted in a global public health crisis, causing substantial concern especially to pregnant population. Pregnant women infected with SARS-CoV-2 are at greater risk devastating pregnancy complications such as premature delivery and stillbirth. Irrespective emerging reported cases neonatal COVID-19, reassuringly, confirmatory evidence vertical transmission is still lacking. protective role placenta limiting utero spread virus developing fetus intriguing. short- long-term impact maternal COVID-19 infection newborn remains an unresolved question. In this review, we explore recent transmission, cell-entry pathways, placental responses towards infection, its potential effects on offspring. We further discuss how serves defensive front against exerting various cellular molecular defense pathways. A better understanding barrier, immune defense, modulation strategies involved restricting transplacental may provide valuable insights for future development antiviral immunomodulatory therapies improve outcomes.

Язык: Английский

---

SARS-CoV-2 infection and female reproductive health: A narrative review

Best Practice & Research Clinical Endocrinology & Metabolism, Год журнала: 2023, Номер 37(4), С. 101760 - 101760

Опубликована: Март 1, 2023

Язык: Английский

---

Placental Infection with Different SARS-CoV-2 Variants Leading to Stillbirth: Report of Two Cases

COVID, Год журнала: 2025, Номер 5(1), С. 8 - 8

Опубликована: Янв. 4, 2025

SARS-CoV-2 placental infection, also known as placentitis (SP), is an established cause of stillbirth; however, this pathology rare and its incidence across different viral variants unknown. We report two new cases SP-associated stillbirth in the third trimester pregnancy. The were identified by a retrospective review 84 fetal autopsies performed at our institution from 1 March 2020 to 2024. In one case, mother was previously healthy asymptomatic for COVID-19. second had history multiple sclerosis (MS) suffered recurrent moderate-to-severe both cases, placentas showed SP with massive perivillous fibrin deposition (PVFD), involving more than 90% discs, resulting insufficiency lethal hypoxic–ischemic injury fetuses. Placental tissues positive situ hybridization (ISH) immunohistochemistry (IHC). Sequencing revealed delta variant Case omicron XBB.1.515 2. data demonstrate that SP, albeit rare, continues intrauterine demise (IUFD) regardless clinical severity infection. persistence COVID-19 becomes globally endemic emphasizes importance disease prevention

Язык: Английский

---

A survey of SARS-CoV-2 tropism

Infectious Diseases & Immunity, Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has significantly burdened global public health. However, the tropism of SARS-CoV-2 within human body remains not fully understood. In this review, we overview literature on infection across various organs and tissues. We summarize relevant specimen types, techniques for examining tropism, findings at both organ/tissue cellular levels. To systematically evaluate evidence supporting tissue establish a hierarchical classification system based two key criteria: (1) origin (2) detection methodology. Clinical specimens obtained directly from COVID-19 patients provide most definitive evidence, whereas organoid-derived animal models indicate potential infectivity under artificial conditions. terms methods, prioritize viral particle identification over protein or RNA detection, as latter requires further confirmation to productive infection. Our that potentially targets multiple organ systems, including tract, lungs, kidneys, heart, blood vessels, pancreas, small intestine, liver, salivary glands. By contrast, central nervous reproductive uncertain validation. At level, identify specific target cell types vulnerable infection, ciliated epithelial cells, alveolar type II pneumocytes, enterocytes, cardiomyocytes, vascular endothelial renal tubular pancreatic acinar cells. Furthermore, analyze correlation between angiotensin-converting enzyme receptor distribution patterns well variations in specificity among different variants. expect review comprehensive landscape enhance our understanding life cycle consequences body.

Язык: Английский

---

Predictive factors for severe placental damage in pregnant women with SARS-CoV-2 infection

Placenta, Год журнала: 2023, Номер 136, С. 1 - 7

Опубликована: Март 17, 2023

Язык: Английский

---

Impact of COVID-19 on pregnant women's health: Consequences in obstetrics two years after the pandemic

Journal of Reproductive Immunology, Год журнала: 2023, Номер 158, С. 103981 - 103981

Опубликована: Июнь 15, 2023

Язык: Английский

---

Causes and Effects of COVID-19 Vaccine Hesitancy Among Pregnant Women and its Association with Adverse Maternal, Placental, and Perinatal Outcomes

The Yale Journal of Biology and Medicine, Год журнала: 2024, Номер 97(1), С. 73 - 84

Опубликована: Март 29, 2024

Populations identified to be severely affected by COVID-19, such as pregnant patients, require special consideration in vaccine counseling, access, and provider education. Maternal infection with COVID-19 poses a significant risk the maternal-fetal dyad known adverse placenta destruction [1-5]. Despite widespread access availability of vaccinations, hesitancy continues persist is highly prevalent populations [6-9]. Addressing multitude social ecological factors surrounding can aid providing holistic counseling [10]. However, are foremost shaped maternal concern over possible fetal effects from vaccination. While changes policy help foster acceptance, increasing global education incorporation motivational interviewing skills first steps towards acceptance.

Язык: Английский

---

SARS-CoV-2 Infection and Pregnancy: Maternal and Neonatal Outcomes and Placental Pathology Correlations

Viruses, Год журнала: 2022, Номер 14(9), С. 2043 - 2043

Опубликована: Сен. 14, 2022

There is accumulating evidence on the perinatal aspects of COVID-19, but available data are still insufficient. The reports COVID-19 have been published a small group patients. Vertical transmission has noted. SARS-CoV-2 genome can be detected in umbilical cord blood and at-term placenta, infants demonstrate elevated SARS-CoV-2-specific IgG IgM antibody levels. In this work, analysis clinical characteristics RT-PCR SARS-CoV-2-positive pregnant women their infants, along with placental pathology correlation results, including villous trophoblast immunoexpression status for antibody, presented. amniotic fluid testing was performed. Neonatal surveillance infection comprised nasopharyngeal swab measuring levels anti-SARS-CoV-2 serum. initial study were 161 positive test results. From that group, who delivered during hospital stay selected further analysis. Clinical data, laboratory histomorphology neonatal outcomes compared immunohistochemistry (IHC)-con IHC SARS-CoV-2-negative placentas (26 cases). A immunoprofile noted 8% cases (n = 2), whereas 92% negative 24). Women proven by had significantly different pathological findings from those without. One infected neonate 1; 4%). Infection confirmed autopsy, as there intrauterine fetal demise. potential course risk vertical implications fetal–neonatal condition critical proper management, which will involve comprehensive, multidisciplinary care

Язык: Английский

---